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- 1From: PLoS Genetics. (Vol. 6, Issue 2) Peer-ReviewedMulticellular animals match costly activities, such as growth and reproduction, to the environment through nutrient-sensing pathways. The insulin/IGF signaling (IIS) pathway plays key roles in growth, metabolism, stress...
- 2From: PLoS Genetics. (Vol. 6, Issue 2) Peer-ReviewedThe natural transfer of DNA from mitochondria to the nucleus generates nuclear copies of mitochondrial DNA (numts) and is an ongoing evolutionary process, as genome sequences attest. In humans, five different numts...
- 3From: PLoS Genetics. (Vol. 6, Issue 2) Peer-ReviewedThe cooperative developmental system of the social amoeba Dictyostelium discoideum is susceptible to exploitation by cheaters--strains that make more than their fair share of spores in chimerae. Laboratory screens in...
- 4From: PLoS Genetics. (Vol. 6, Issue 2) Peer-ReviewedAmong primates, genome-wide analysis of recent positive selection is currently limited to the human species because it requires extensive sampling of genotypic data from many individuals. The extent to which genes...
- 5From: PLoS Genetics. (Vol. 6, Issue 2) Peer-ReviewedThe aesthetic appeal of butterfly wing patterns has been costly to their status as a tool of fundamental scientific inquiry. Thus, while mimetic convergence in wing patterns between edible "Batesian" mimics and...
- 6From: PLoS Genetics. (Vol. 6, Issue 2) Peer-ReviewedControl and coordination of eukaryotic gene expression rely on transcriptional and posttranscriptional regulatory networks. Evolutionary innovations and adaptations often require rapid changes of such networks. It has...
- 7From: PLoS Genetics. (Vol. 6, Issue 2) Peer-ReviewedTooth development is a highly heritable process which relates to other growth and developmental processes, and which interacts with the development of the entire craniofacial complex. Abnormalities of tooth development...
- 8From: PLoS Genetics. (Vol. 6, Issue 2) Peer-ReviewedThe histiocytoses are a heterogeneous group of disorders characterised by an excessive number of histiocytes. In most cases the pathophysiology is unclear and treatment is nonspecific. Faisalabad histiocytosis (FHC)...
- 9From: PLoS Genetics. (Vol. 6, Issue 2) Peer-ReviewedIn a previous study, we showed that centromere repositioning, that is the shift along the chromosome of the centromeric function without DNA sequence rearrangement, has occurred frequently during the evolution of the...
- 10From: PLoS Genetics. (Vol. 6, Issue 2) Peer-ReviewedBacteria of the Thiomonas genus are ubiquitous in extreme environments, such as arsenic-rich acid mine drainage (AMD). The genome of one of these strains, Thiomonas sp. 3As, was sequenced, annotated, and examined,...
- 11From: PLoS Genetics. (Vol. 6, Issue 2) Peer-ReviewedNext-generation sequencing technology provides novel opportunities for gathering genome-scale sequence data in natural populations, laying the empirical foundation for the evolving field of population genomics. Here we...
- 12From: PLoS Genetics. (Vol. 6, Issue 2) Peer-ReviewedCentromeres are the attachment points between the genome and the cytoskeleton: centromeres bind to kinetochores, which in turn bind to spindles and move chromosomes. Paradoxically, the DNA sequence of centromeres has...
- 13From: PLoS Genetics. (Vol. 6, Issue 2) Peer-ReviewedTranscription factors are key components of regulatory networks that control development, as well as the response to environmental stimuli. We have established an experimental pipeline in Caenorhabditis elegans that...
- 14From: PLoS Genetics. (Vol. 6, Issue 2) Peer-ReviewedWing pattern evolution in Heliconius butterflies provides some of the most striking examples of adaptation by natural selection. The genes controlling pattern variation are classic examples of Mendelian loci of large...
- 15From: PLoS Genetics. (Vol. 6, Issue 2) Peer-ReviewedThe population structure of an organism reflects its evolutionary history and influences its evolutionary trajectory. It constrains the combination of genetic diversity and reveals patterns of past gene flow....
- 16From: PLoS Genetics. (Vol. 6, Issue 2) Peer-ReviewedA large number of rare sequence variants of unknown clinical significance have been identified in the breast cancer susceptibility genes, BRCA1 and BRCA2. Laboratory-based methods that can distinguish between carriers...
- 17From: PLoS Genetics. (Vol. 6, Issue 2) Peer-ReviewedGenome-wide association studies in human populations have facilitated the creation of genomic profiles which combine the effects of many associated genetic variants to predict risk of disease. The area under the...
- 18From: PLoS Genetics. (Vol. 6, Issue 2) Peer-ReviewedHistone modifications affect DNA-templated processes ranging from transcription to genomic replication. In this study, we examine the cell cycle dynamics of the trimethylated form of histone H3 lysine 4 (H3K4me3), a...
- 19From: PLoS Genetics. (Vol. 6, Issue 2) Peer-ReviewedThe repair of DNA double-strand breaks (DSBs) is critical for the maintenance of genomic integrity and viability for all organisms. Mammals have evolved at least two genetically discrete ways to mediate DNA DSB repair:...
- 20From: PLoS Genetics. (Vol. 6, Issue 2) Peer-ReviewedSystemic lupus erythematosus is a complex and potentially fatal autoimmune disease, characterized by autoantibody production and multi-organ damage. By a genome-wide association study (320 patients and 1,500 controls)...