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- Search Terms:ISSN: 15537366AndISSN: 15537374AndVolume Number: 6AndIssue Number: 2AndStart Page: e1000762AndDate: 2010 Revise Search
- 1From: PLoS Pathogens. (Vol. 6, Issue 2) Peer-ReviewedStimulation and release of proinflammatory cytokines is an essential step for the activation of an effective innate host defense, and subsequently for the modulation of adaptive immune responses. Interleukin-1β (IL-1β)...
- 2From: PLoS Pathogens. (Vol. 6, Issue 2) Peer-ReviewedProtein kinases play key roles in signaling and response to changes in the external environment. The ability of Candida albicans to quickly sense and respond to changes in its environment is key to its survival in the...
- 3From: PLoS Pathogens. (Vol. 6, Issue 2) Peer-ReviewedA universal feature of metazoan sexual development is the generation of oocyte P granules that withhold certain mRNA species from translation to provide coding potential for proteins during early post-fertilization...
- 4From: PLoS Pathogens. (Vol. 6, Issue 2) Peer-ReviewedFungal pathologies are seen in immunocompromised and healthy humans. C-type lectins expressed on immature dendritic cells (DC) recognize fungi. We report a novel dorsal pseudopodial protrusion, the "fungipod", formed by...
- 5From: PLoS Pathogens. (Vol. 6, Issue 2) Peer-ReviewedWe have developed an efficient method to quantify cell-to-cell infection with single-cycle, replication dependent reporter vectors. This system was used to examine the mechanisms of infection with HTLV-1 and HIV-1...
- 6From: PLoS Pathogens. (Vol. 6, Issue 2) Peer-ReviewedCytosine-5 methyltransferases of the Dnmt2 family function as DNA and tRNA methyltransferases. Insight into the role and biological significance of Dnmt2 is greatly hampered by a lack of knowledge about its protein...
- 7From: PLoS Pathogens. (Vol. 6, Issue 2) Peer-ReviewedWe have used multiplexed high-throughput sequencing to characterize changes in small RNA populations that occur during viral infection in animal cells. Small RNA-based mechanisms such as RNA interference (RNAi) have...
- 8From: PLoS Pathogens. (Vol. 6, Issue 2) Peer-ReviewedIn man, infection with South American Andes virus (ANDV) causes hantavirus cardiopulmonary syndrome (HCPS). HCPS due to ANDV is endemic in Southern Chile and much of Argentina and increasing numbers of cases are...
- 9From: PLoS Pathogens. (Vol. 6, Issue 2) Peer-ReviewedTetherin/BST2 was identified in 2008 as the cellular factor responsible for restricting HIV-1 replication at a very late stage in the lifecycle. Tetherin acts to retain virion particles on the plasma membrane after...
- 10From: PLoS Pathogens. (Vol. 6, Issue 2) Peer-ReviewedThere is great interindividual variability in HIV-1 viral setpoint after seroconversion, some of which is known to be due to genetic differences among infected individuals. Here, our focus is on determining,...
- 11From: PLoS Pathogens. (Vol. 6, Issue 2) Peer-ReviewedMany Gram-negative bacteria colonize and exploit host niches using a protein apparatus called a type III secretion system (T3SS) that translocates bacterial effector proteins into host cells where their functions are...
- 12From: PLoS Pathogens. (Vol. 6, Issue 2) Peer-ReviewedChronic immune activation and inflammation (e.g., as manifest by production of type I interferons) are major determinants of disease progression in primate lentivirus infections. To investigate the impact of such...
- 13From: PLoS Pathogens. (Vol. 6, Issue 2) Peer-ReviewedToxoplasma gondii is a leading cause of congenital birth defects, as well as a cause for ocular and neurological diseases in humans. Its cytoskeleton is essential for parasite replication and invasion and contains many...
- 14From: PLoS Pathogens. (Vol. 6, Issue 2) Peer-ReviewedThe signal transduction protein SmTK4 from Schistosoma mansoni belongs to the family of Syk kinases. In vertebrates, Syk kinases are known to play specialized roles in signaling pathways in cells of the hematopoietic...
- 15From: PLoS Pathogens. (Vol. 6, Issue 2) Peer-ReviewedYersinia pestis, the agent of plague, is transmitted to mammals by infected fleas. Y. pestis exhibits a distinct life stage in the flea, where it grows in the form of a cohesive biofilm that promotes transmission. After...
- 16From: PLoS Pathogens. (Vol. 6, Issue 2) Peer-ReviewedThe innate immune response is essential for controlling West Nile virus (WNV) infection but how this response is propagated and regulates adaptive immunity in vivo are not defined. Herein, we show that IPS-1, the...
- 17From: PLoS Pathogens. (Vol. 6, Issue 2) Peer-ReviewedAntibodies constitute a critical component of the naturally acquired immunity that develops following frequent exposure to malaria. However, specific antibody titres have been reported to decline rapidly in the absence...
- 18From: PLoS Pathogens. (Vol. 6, Issue 2) Peer-ReviewedVaccinia virus (VACV) uses microtubules for export of virions to the cell surface and this process requires the viral protein F12. Here we show that F12 has structural similarity to kinesin light chain (KLC), a subunit...
- 19From: PLoS Pathogens. (Vol. 6, Issue 2) Peer-ReviewedThe invasion of erythrocytes by Plasmodium merozoites requires specific interactions between host receptors and parasite ligands. Parasite proteins that bind erythrocyte receptors during invasion are localized in apical...
- 20From: PLoS Pathogens. (Vol. 6, Issue 2) Peer-ReviewedThe innate immune response provides a critical defense against microbial infections, including viruses. These are recognised by pattern recognition receptors including Toll-like receptors (TLRs) and RIG-I like helicases...