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- 1From: Nature Reviews Genetics. (Vol. 6, Issue 2) Peer-ReviewedAuthor(s): William Y. S. Wang [1, 2]; Bryan J. Barratt [1, 3]; David G. Clayton [1]; John A. Todd (corresponding author) [1] The development of common disease results from complex interactions between numerous...
- 2From: Nature Reviews Genetics. (Vol. 6, Issue 2) Peer-ReviewedAuthor(s): David Patterson (corresponding author) [1]; Alberto C. S. Costa [1] We have known since the late 1950s that Down syndrome, which occurs in about 1 in 800 live births [1], is the result of the trisomy of...
- 3From: Nature Reviews Genetics. (Vol. 6, Issue 2) Peer-ReviewedAuthor(s): H. Allen Orr [1] Adaptation is not natural selection. As Ronald A. Fisher [1] emphasized in 1930, adaptation is characterized by the movement of a population towards a phenotype that best fits the present...
- 4From: Nature Reviews Genetics. (Vol. 6, Issue 2) Peer-ReviewedAuthor(s): Joel N. Hirschhorn (corresponding author) [1, 2, 3]; Mark J. Daly [1, 4] We have recently seen the completion of the human genome sequence [1, 2], the deposition of millions of SNPs into public databases...
- 5From: Nature Reviews Genetics. (Vol. 6, Issue 2) Peer-ReviewedAuthor(s): Nick Campbell [1] A painstaking new analysis fills in some important gaps in our knowledge of how the human genome repairs the double strand breaks (DSBs) in DNA that are induced by ionizing radiation...
- 6From: Nature Reviews Genetics. (Vol. 6, Issue 2) Peer-ReviewedAuthor(s): Jenny Bangham The tumour suppressor p53 binds DNA and activates transcription to control the cell cycle and apoptosis, and is mutated in over 50% of human cancers. Mutations in TP53 also cause Li-Fraumeni...
- 7From: Nature Reviews Genetics. (Vol. 6, Issue 2) Peer-ReviewedStem cells p53 induces differentiation of mouse embryonic stem cells by suppressing Nanog expression . Lin, T. et al . Nature Cell Biol. 26 December 2004 (10.1038/ncb1211) Responding effectively to DNA damage...
- 8From: Nature Reviews Genetics. (Vol. 6, Issue 2) Peer-ReviewedAuthor(s): Magdalena Skipper Recent work by Matthew Ronshaugen and Mike Levine shows that interactions between enhancers and promoters most probably involve looping of the intervening DNA. The authors, who were...
- 9From: Nature Reviews Genetics. (Vol. 6, Issue 2) Peer-ReviewedAuthor(s): Tanita Casci Many species go to great lengths to prevent or at least minimize mating between close relatives -- or, in the case of plants, with themselves. Nematodes, on the other hand, show a blatant...
- 10From: Nature Reviews Genetics. (Vol. 6, Issue 2) Peer-ReviewedAuthor(s): Magdalena Skipper Gone are the days when oligonucleotide microarrays were used only to study gene expression; their function in genotyping studies, for example, has arguably overtaken their original...
- 11From: Nature Reviews Genetics. (Vol. 6, Issue 2) Peer-ReviewedAuthor(s): Louisa Flintoft As a reproductive strategy, sex has its pluses and minuses: it ensures genetic diversity but, unlike asexual reproduction, it means that parents pass on only 50% of their genes. Reporting...
- 12From: Nature Reviews Genetics. (Vol. 6, Issue 2) Peer-ReviewedAuthor(s): Tanita Casci Although 50 years of molecular genetics might have come a considerable way towards answering age-old questions in evolutionary biology -- not least the realization that DNA mutations provide...
- 13From: Nature Reviews Genetics. (Vol. 6, Issue 2) Peer-ReviewedAuthor(s): Tanita Casci A bereaved cat owner has paid a Californian biotechnology company the handsome sum of 50,000 US$ for the genetic clone of her dead moggie, Nicky. The buyer in question, a woman from Texas who...
- 14From: Nature Reviews Genetics. (Vol. 6, Issue 2) Peer-ReviewedNewborn screening (NBS) is a public-health genetic screening programme aimed at early detection and treatment of pre-symptomatic children affected by specific disorders. It currently involves protein-based assays and...
- 15From: Nature Reviews Genetics. (Vol. 6, Issue 2) Peer-ReviewedAuthor(s): Louisa Flintoft Silencing of whole regions of chromosomes by packaging them into heterochromatin provides an effective way of shutting off gene expression. But what keeps heterochromatin from invading...
- 16From: Nature Reviews Genetics. (Vol. 6, Issue 2) Peer-ReviewedAuthor(s): Tanita Casci In genetics, as in many other fields, theoretical models rarely provide good substitutes for empirical evidence; after all, who would continue to uphold a model that has been contradicted by...
- 17From: Nature Reviews Genetics. (Vol. 6, Issue 2) Peer-ReviewedEvo-Devo Ancestral role of caudal genes in axis elongation and segmentation . Copf, T. et al . Proc. Natl Acad. Sci. USA 101, 17711-17715 (2004) Caudal genes are known for their role in posterior patterning. By...
- 18From: Nature Reviews Genetics. (Vol. 6, Issue 2) Peer-ReviewedMammalian genomes contain highly conserved sequences that are not functionally transcribed. These sequences are single copy and comprise approximately 1-2% of the human genome. Evolutionary analysis strongly supports...
- 19From: Nature Reviews Genetics. (Vol. 6, Issue 2) Peer-ReviewedThe genomes of multicellular eukaryotes provide information that determines the phenotype. However, not all sequences in the genome are required for this purpose. Other sequences are often selfish in their actions and...