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- Search Terms:ISSN: 15537390AndISSN: 15537404AndVolume Number: 6AndIssue Number: 12AndStart Page: e1001189AndDate: 2010 Revise Search
- 1From: PLoS Genetics. (Vol. 6, Issue 12) Peer-ReviewedTransgenic crops producing insecticidal toxins from Bacillus thuringiensis (Bt) are commercially successful in reducing pest damage, yet knowledge of resistance mechanisms that threaten their sustainability is...
- 2From: PLoS Genetics. (Vol. 6, Issue 12) Peer-ReviewedEndocytic sorting is achieved through the formation of morphologically and functionally distinct sub-domains within early endosomes. Cargoes destined for recycling are sorted to and transported through newly-formed...
- 3From: PLoS Genetics. (Vol. 6, Issue 12) Peer-ReviewedIn mammals, parathyroid hormone (PTH) is a key regulator of extracellular calcium and inorganic phosphorus homeostasis. Although the parathyroid glands were thought to be the only source of PTH, extra-parathyroid PTH...
- 4From: PLoS Genetics. (Vol. 6, Issue 12) Peer-ReviewedPTEN-induced kinase 1 (PINK1), which is required for mitochondrial homeostasis, is a gene product responsible for Early-onset Parkinson's disease (PD). Another early onset PD gene product, Parkin, has been suggested to...
- 5From: PLoS Genetics. (Vol. 6, Issue 12) Peer-ReviewedChronic inflammatory arthritis, a hallmark of several inflammatory rheumatic diseases, and inflammatory bowel disease are both life-long conditions, with substantial morbidity and even mortality. These diseases are...
- 6From: PLoS Genetics. (Vol. 6, Issue 12) Peer-ReviewedWe have investigated in vivo the role of the carboxy-terminal domain of the Bacillus subtilis Single-Stranded DNA Binding protein ([SSB.sub.Cter]) as a recruitment platform at active chromosomal forks for many proteins...
- 7From: PLoS Genetics. (Vol. 6, Issue 12) Peer-ReviewedA >300 kb cis-regulatory region is required for the proper expression of the three bithorax complex (BX-C) homeotic genes. Based on genetic and transgenic analysis, a model has been proposed in which the numerous BX-C...
- 8From: PLoS Genetics. (Vol. 6, Issue 12) Peer-ReviewedWhile the majority of multiexonic human genes show some evidence of alternative splicing, it is unclear what fraction of observed splice forms is functionally relevant. In this study, we examine the extent of...
- 9From: PLoS Genetics. (Vol. 6, Issue 12) Peer-ReviewedThe fungus Mycosphaerella graminicola has been a pathogen of wheat since host domestication 10,000-12,000 years ago in the Fertile Crescent. The wheat-infecting lineage emerged from closely related Mycosphaerella...
- 10From: PLoS Genetics. (Vol. 6, Issue 12) Peer-ReviewedHumans respond differently than other primates to a large number of infections. Differences in susceptibility to infectious agents between humans and other primates are probably due to inter-species differences in...
- 11From: PLoS Genetics. (Vol. 6, Issue 12) Peer-ReviewedTransposons and other selfish DNA elements can be found in all phyla, and mobilization of these elements can compromise genome integrity. The piRNA (PIWI-interacting RNA) pathway silences transposons in the germline,...
- 12From: PLoS Genetics. (Vol. 6, Issue 12) Peer-ReviewedHuman genome-wide association studies have linked single nucleotide polymorphisms (SNPs) on chromosome 9p21.3 near the INK4/ARF (CDKN2a/b) locus with susceptibility to atherosclerotic vascular disease (ASVD). Although...
- 13From: PLoS Genetics. (Vol. 6, Issue 12) Peer-ReviewedEchinoderms, which are phylogenetically related to vertebrates and produce large numbers of transparent embryos that can be experimentally manipulated, offer many advantages for the analysis of the gene regulatory...
- 14From: PLoS Genetics. (Vol. 6, Issue 12) Peer-ReviewedOver half of all proteins are glycosylated, and alterations in glycosylation have been observed in numerous physiological and pathological processes. Attached glycans significantly affect protein function; but, contrary...
- 15From: PLoS Genetics. (Vol. 6, Issue 12) Peer-ReviewedAn increasing number of genetic variants have been identified for many complex diseases. However, it is controversial whether risk prediction based on genomic profiles will be useful clinically. Appropriate statistical...
- 16From: PLoS Genetics. (Vol. 6, Issue 12) Peer-ReviewedMany bacteria inhibit motility concomitant with the synthesis of an extracellular polysaccharide matrix and the formation of biofilm aggregates. In Bacillus subtilis biofilms, motility is inhibited by EpsE, which acts...
- 17From: PLoS Genetics. (Vol. 6, Issue 12) Peer-ReviewedGlycosylation plays crucial regulatory roles in various biological processes such as development, immunity, and neural functions. For example, [alpha]1,3-fucosylation, the addition of a fucose moiety abundant in...
- 18From: PLoS Genetics. (Vol. 6, Issue 12) Peer-ReviewedUnderstanding the function of important DNA elements in mammalian stem cell genomes would be enhanced by the availability of deletion collections in which segmental haploidies are precisely characterized. Using a...
- 19From: PLoS Genetics. (Vol. 6, Issue 12) Peer-ReviewedRecent studies demonstrated a strong influence of rare genetic variants on several lipid-related traits. However, their impact on free fatty acid (FFA) plasma concentrations, as well as the role of rare variants in a...
- 20From: PLoS Genetics. (Vol. 6, Issue 12) Peer-ReviewedTissue-encysting coccidia, including Toxoplasma gondii and Sarcocystis neurona, are heterogamous parasites with sexual and asexual life stages in definitive and intermediate hosts, respectively. During its sexual life...