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- 1From: Nature Immunology. (Vol. 6, Issue 12) Peer-ReviewedAuthor(s): Karsten Kretschmer [1]; Irina Apostolou [1]; Daniel Hawiger [2]; Khashayarsha Khazaie [1]; Michel C Nussenzweig [3, 4]; Harald von Boehmer (corresponding author) [1] CD4+ CD25+ regulatory T cells expressing...
- 2From: Nature Immunology. (Vol. 6, Issue 12) Peer-ReviewedAuthor(s): Charles N Serhan (corresponding author) [1]; John Savill [2] In 1794, Scottish surgeon John Hunter wrote that "Inflammation in itself is not to be considered as a disease but as a salutary operation...
- 3From: Nature Immunology. (Vol. 6, Issue 12) Peer-ReviewedAuthor(s): Tadashi Yokosuka [1]; Kumiko Sakata-Sogawa [2]; Wakana Kobayashi [1]; Michio Hiroshima [2]; Akiko Hashimoto-Tane [1]; Makio Tokunaga [2, 3, 4]; Michael L Dustin [5]; Takashi Saito (corresponding author) [1]...
- 4From: Nature Immunology. (Vol. 6, Issue 12) Peer-ReviewedControlling migration Cell migration is integral to the inflammatory response, but leukocyte trafficking must be properly regulated to avoid infiltration of cells into healthy tissues. Barriers such as the maintenance...
- 5From: Nature Immunology. (Vol. 6, Issue 12) Peer-ReviewedAuthor(s): Alain Trautmann [1] The formation of the 'immunological synapse' requires the coalescence of 'signalosomes' that consist of (at least) receptors, kinases, phosphatases and adaptors in cell-cell contact...
- 6From: Nature Immunology. (Vol. 6, Issue 12) Peer-ReviewedThe [gamma][delta] T cells are prevalent in the mucosal epithelia and are postulated to act as 'sentries' for maintaining tissue integrity. What these [gamma][delta] T cells recognize is poorly defined, but given the...
- 7From: Nature Immunology. (Vol. 6, Issue 12) Peer-ReviewedAuthor(s): Paul Anderson [1] Pin1 is a member of a family of peptidyl-prolyl isomerases that catalyze the cis-trans isomerization of peptide bonds N-terminal to proline residues in polypeptide chains. Pin1...
- 8From: Nature Immunology. (Vol. 6, Issue 12) Peer-ReviewedThe burgeoning field of leukocyte trafficking has created new and exciting opportunities in the clinic. Trafficking signals are being defined that finely control the movement of distinct subsets of immune cells into and...
- 9From: Nature Immunology. (Vol. 6, Issue 12) Peer-ReviewedThe study of 'inflammare ', or inflammation, which describes the basic process whereby tissues respond to traumatic, infectious, ischemic, toxic or autoimmune injury, dates back over 3,000 years. The Roman Celsus,...
- 10From: Nature Immunology. (Vol. 6, Issue 12) Peer-ReviewedVariable (diversity) joining (V(D)J) recombination is initiated by the introduction of single-strand DNA breaks (nicks) at recombination signal sequences (RSSs). The importance and fate of these RSS nicks for the...
- 11From: Nature Immunology. (Vol. 6, Issue 12) Peer-ReviewedTwo seemingly unrelated hallmarks of memory CD8[sup.+] T cells are cytokine-driven proliferative renewal after pathogen clearance and a latent effector program in anticipation of rechallenge. Memory CD8[sup.+] T cells...
- 12From: Nature Immunology. (Vol. 6, Issue 12) Peer-ReviewedHappy Eater Receptors in addition to SR-CI and PGRP-LC are believed to mediate phagocytosis in drosophila. In Cell , Kocks et al . identify Eater, a cell surface receptor with epidermal growth factor-like repeats, as...
- 13From: Nature Immunology. (Vol. 6, Issue 12) Peer-ReviewedTim-3 is a T helper type 1 (T[sub.H]1)-specific cell surface molecule that seems to regulate T[sub.H]1 responses and the induction of peripheral tolerance. However, the identity of the Tim-3 ligand and the mechanism by...
- 14From: Nature Immunology. (Vol. 6, Issue 12) Peer-ReviewedThis series of reviews addresses mechanisms whereby inflammation can be reduced, turned off or perhaps prevented, both in the context of natural dampening processes as well as possible approaches to anti-inflammatory...
- 15From: Nature Immunology. (Vol. 6, Issue 12) Peer-ReviewedThe idea of the importance of mounting an inflammatory response for effective immunity is supported by a multiplicity of experimental data. It is also well understood that resolution of inflammation is essential for...
- 16From: Nature Immunology. (Vol. 6, Issue 12) Peer-ReviewedEmerging insights into the mechanisms of activation and negative regulation of innate and adaptive immune cells are providing new opportunities for the development of safe and effective cancer vaccines. Author(s):...
- 17From: Nature Immunology. (Vol. 6, Issue 12) Peer-ReviewedThe infiltration, accumulation and degranulation of eosinophils in the lung represents a hallmark of active asthma. In vivo or in vitro eosinophil activation triggers the secretion of the antiapoptotic cytokine...
- 18From: Nature Immunology. (Vol. 6, Issue 12) Peer-ReviewedAuthor(s): Klaus Ley [1]; Maggie Morris [2] Lymphocyte egress from both primary and secondary lymphoid tissue requires the lipid mediator sphingosine 1-phosphate (S1P), which is thought to induce this effect through...
- 19From: Nature Immunology. (Vol. 6, Issue 12) Peer-ReviewedSphingosine 1-phosphate type 1 (S1P[sub.1]) receptor agonists cause sequestration of lymphocytes in secondary lymphoid organs by a mechanism that is not well understood. One hypothesis proposes that agonists act as...