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- Search Terms:ISSN: 15537390AndISSN: 15537404AndVolume Number: 6AndIssue Number: 11AndStart Page: e1001190AndDate: 2010 Revise Search
- 1From: PLoS Genetics. (Vol. 6, Issue 11) Peer-ReviewedGene expression responds to changes in conditions but also stochastically among individuals. In budding yeast, both expression responsiveness across conditions ("plasticity") and cell-to-cell variation ("noise") have...
- 2From: PLoS Genetics. (Vol. 6, Issue 11) Peer-ReviewedNatural killer (NK) cells serve essential functions in immunity and reproduction. Diversifying these functions within individuals and populations are rapidly-evolving interactions between highly polymorphic major...
- 3From: PLoS Genetics. (Vol. 6, Issue 11) Peer-ReviewedObesity has a strong genetic component, but few of the genes that predispose to obesity are known. Genetic screens in invertebrates have the potential to identify genes and pathways that regulate the levels of stored...
- 4From: PLoS Genetics. (Vol. 6, Issue 11) Peer-ReviewedIn mammals, imprinted gene expression results from the sex-specific methylation of imprinted control regions (ICRs) in the parental germlines. Imprinting is linked to therian reproduction, that is, the placenta and...
- 5From: PLoS Genetics. (Vol. 6, Issue 11) Peer-ReviewedNatural selection sculpts phenotypes to enable adaptation to local conditions. Biologists have long been interested in the phenotypic and molecular response to selection, but we still know little about the genetic basis...
- 6From: PLoS Genetics. (Vol. 6, Issue 11) Peer-ReviewedThe Caenorhabditis elegans inner nuclear envelope protein matefin/SUN-1 plays a conserved, pivotal role in the process of genome haploidization. CHK-2-dependent phosphorylation of SUN-1 regulates homologous chromosome...
- 7From: PLoS Genetics. (Vol. 6, Issue 11) Peer-ReviewedDiscovering links between the genotype of an organism and its metabolite levels can increase our understanding of metabolism, its controls, and the indirect effects of metabolism on other quantitative traits. Recent...
- 8From: PLoS Genetics. (Vol. 6, Issue 11) Peer-ReviewedCilia are important sensory organelles, which are thought to be essential regulators of numerous signaling pathways. In Caenorhabditis elegans, defects in sensory cilium formation result in a small-body phenotype,...
- 9From: PLoS Genetics. (Vol. 6, Issue 11) Peer-ReviewedTo understand the genetic mechanisms leading to phenotypic differentiation, it is important to identify genomic regions under selection. We scanned the genome of two chicken lines from a single trait selection...
- 10From: PLoS Genetics. (Vol. 6, Issue 11) Peer-ReviewedIn eukaryotes, 45S rRNA genes are arranged in tandem arrays in copy numbers ranging from several hundred to several thousand in plants. Although it is clear that not all copies are transcribed under normal growth...
- 11From: PLoS Genetics. (Vol. 6, Issue 11) Peer-ReviewedSUMO modification of transcription factors is linked to repression of transcription. The physiological significance of SUMO attachment to a particular transcriptional regulator, however, is largely unknown. We have...
- 12From: PLoS Genetics. (Vol. 6, Issue 11) Peer-Reviewed
Genetic basis of growth adaptation of escherichia coli after deletion of pgi, a major metabolic gene
Bacterial survival requires adaptation to different environmental perturbations such as exposure to antibiotics, changes in temperature or oxygen levels, DNA damage, and alternative nutrient sources. During adaptation,... - 13From: PLoS Genetics. (Vol. 6, Issue 11) Peer-Reviewedcis-regulatory DNA sequences known as enhancers control gene expression in space and time. They are central to metazoan development and are often responsible for changes in gene regulation that contribute to phenotypic...
- 14From: PLoS Genetics. (Vol. 6, Issue 11) Peer-ReviewedYeast DNA polymerase [epsilon] (Pol [epsilon]) is a highly accurate and processive enzyme that participates in nuclear DNA replication of the leading strand template. In addition to a large subunit (Pol2) harboring the...
- 15From: PLoS Genetics. (Vol. 6, Issue 11) Peer-ReviewedCircadian rhythms are daily biological oscillations driven by an endogenous mechanism known as circadian clock. The protein kinase CK2 is one of the few clock components that is evolutionary conserved among different...
- 16From: PLoS Genetics. (Vol. 6, Issue 11) Peer-ReviewedMethylation of DNA and of Lysine 9 on histone H3 (H3K9) is associated with gene silencing in many animals, plants, and fungi. In Neurospora crassa, methylation of H3K9 by DIM-5 directs cytosine methylation by recruiting...
- 17From: PLoS Genetics. (Vol. 6, Issue 11) Peer-ReviewedPrevious genome-wide association (GWA) studies have identified SNPs associated with areal bone mineral density (aBMD). However, this measure is influenced by several different skeletal parameters, such as periosteal...
- 18From: PLoS Genetics. (Vol. 6, Issue 11) Peer-ReviewedIn harsh conditions, Caenorhabditis elegans arrests development to enter a non-aging, resistant diapause state called the dauer larva. Olfactory sensation modulates the TGF-[beta] and insulin signaling pathways to...
- 19From: PLoS Genetics. (Vol. 6, Issue 11) Peer-ReviewedTwo-component signal transduction systems enable bacteria to sense and respond to a wide range of environmental stimuli. Sensor histidine kinases transmit signals to their cognate response regulators via...
- 20From: PLoS Genetics. (Vol. 6, Issue 11) Peer-ReviewedMigrating cells and growth cones extend lamellipodial and filopodial protrusions that are required for outgrowth and guidance. The mechanisms of cytoskeletal regulation that underlie cell and growth cone migration are...