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- Search Terms:ISSN: 1553734XAndISSN: 15537358AndVolume Number: 6AndIssue Number: 11AndStart Page: e1000997AndDate: 2010 Revise Search
- 1From: PLoS Computational Biology. (Vol. 6, Issue 11) Peer-ReviewedInteractions between microbial species are sometimes mediated by the exchange of small molecules, secreted by one species and metabolized by another. Both one-way (commensal) and two-way (mutualistic) interactions may...
- 2From: PLoS Computational Biology. (Vol. 6, Issue 11) Peer-ReviewedIt is shown that existing processing schemes of 3D motion perception such as interocular velocity difference, changing disparity over time, as well as joint encoding of motion and disparity, do not offer a general...
- 3From: PLoS Computational Biology. (Vol. 6, Issue 11) Peer-ReviewedThe spatial patterning of proteins in bacteria plays an important role in many processes, from cell division to chemotaxis. In the asymmetrically dividing bacteria Caulobacter crescentus, a scaffolding protein, PopZ,...
- 4From: PLoS Computational Biology. (Vol. 6, Issue 11) Peer-ReviewedThe sensitivity of a neuron to its input can be modulated in several ways. Changes in the slope of the neuronal input-output curve depend on factors such as shunting inhibition, background noise, frequency-dependent...
- 5From: PLoS Computational Biology. (Vol. 6, Issue 11) Peer-ReviewedThe annual international conference on Intelligent Systems for Molecular Biology (ISMB) is the largest meeting of the International Society for Computational Biology (ISCB). In 2010 it was held in Boston, United States,...
- 6From: PLoS Computational Biology. (Vol. 6, Issue 11) Peer-ReviewedTraditionally, the information content of the neural response is quantified using statistics of the responses relative to stimulus onset time with the assumption that the brain uses onset time to infer stimulus...
- 7From: PLoS Computational Biology. (Vol. 6, Issue 11) Peer-ReviewedRecently, a novel approach has been developed to study gene expression in single cells with high time resolution using RNA Fluorescent In Situ Hybridization (FISH). The technique allows individual mRNAs to be counted...
- 8From: PLoS Computational Biology. (Vol. 6, Issue 11) Peer-ReviewedPrediction of drug action in human cells is a major challenge in biomedical research. Additionally, there is strong interest in finding new applications for approved drugs and identifying potential side effects. We...
- 9From: PLoS Computational Biology. (Vol. 6, Issue 11) Peer-ReviewedAn ultimate goal of genetic research is to understand the connection between genotype and phenotype in order to improve the diagnosis and treatment of diseases. The quantitative genetics field has developed a suite of...
- 10From: PLoS Computational Biology. (Vol. 6, Issue 11) Peer-ReviewedRecently, many researchers have used graph theory to study the aberrant brain structures in Alzheimer's disease (AD) and have made great progress. However, the characteristics of the cortical network in Mild Cognitive...
- 11From: PLoS Computational Biology. (Vol. 6, Issue 11) Peer-ReviewedWe study local calcium dynamics leading to a vesicle fusion in a stochastic, and spatially explicit, biophysical model of the CA3-CA1 presynaptic bouton. The kinetic model for vesicle release has two calcium sensors, a...
- 12From: PLoS Computational Biology. (Vol. 6, Issue 11) Peer-ReviewedThe disruption of the circadian system in humans has been associated with the development of chronic illnesses and the worsening of pre-existing pathologies. Therefore, the assessment of human circadian system function...
- 13From: PLoS Computational Biology. (Vol. 6, Issue 11) Peer-ReviewedIt is currently believed that the atlas of existing protein structures is faithfully represented in the Protein Data Bank. However, whether this atlas covers the full universe of all possible protein structures is still...
- 14From: PLoS Computational Biology. (Vol. 6, Issue 11) Peer-ReviewedFor most HIV-infected patients, antiretroviral therapy controls viral replication. However, in some patients drug resistance can cause therapy to fail. Nonetheless, continued therapy with a failing regimen can preserve...
- 15From: PLoS Computational Biology. (Vol. 6, Issue 11) Peer-ReviewedThe oligomerization/co-localization of protein complexes and their cooperative regulation in protein function is a key feature in many biological systems. The synergistic regulation in different subunits often enhances...
- 16From: PLoS Computational Biology. (Vol. 6, Issue 11) Peer-ReviewedHIV-1 escape from the cytotoxic T-lymphocyte (CTL) response leads to a weakening of viral control and is likely to be detrimental to the patient. To date, the impact of escape on viral load and CD[4.sup.+] T cell count...
- 17From: PLoS Computational Biology. (Vol. 6, Issue 11) Peer-ReviewedRecombination is one of the main forces shaping genome diversity, but the information it generates is often overlooked. A recombination event creates a junction between two parental sequences that may be transmitted to...
- 18From: PLoS Computational Biology. (Vol. 6, Issue 11) Peer-ReviewedWe report a computational approach that integrates structural bioinformatics, molecular modelling and systems biology to construct a drug-target network on a structural proteome-wide scale. The approach has been applied...
- 19From: PLoS Computational Biology. (Vol. 6, Issue 11) Peer-ReviewedThe specific binding of regulatory proteins to DNA sequences exhibits no clear patterns of association between amino acids (AAs) and nucleotides (NTs). This complexity of protein-DNA interactions raises the question of...
- 20From: PLoS Computational Biology. (Vol. 6, Issue 11) Peer-ReviewedProtein sequences encompass tertiary structures and contain information about specific molecular interactions, which in turn determine biological functions of proteins. Knowledge about how protein sequences define...