Showing Results for
- Academic Journals (348)
Search Results
- 348
Academic Journals
- 348
- Search Terms:
- 1From: Nature Methods. (Vol. 6, Issue 1) Peer-ReviewedAlthough microRNA target predictions are continually improving, high-throughput validation of direct interaction is still needed. The small but biologically extremely influential microRNAs were again under intense...
- 2From: Nature Methods. (Vol. 6, Issue 5) Peer-ReviewedA new algorithm for identifying evolutionary constraint incorporates information on local DNA topology, and leads to the finding that this topology is conserved across species. Think of the structure of DNA, and what...
- 3From: Nature Methods. (Vol. 6, Issue 7) Peer-ReviewedWang et al. describe the synthesis of quantum dots that exhibit continuous photoluminescence. Other groups have developed various strategies to suppress blinking, but none have completely eliminated blinking. Wang et al....
- 4From: Nature Methods. (Vol. 6, Issue 8) Peer-ReviewedCells can be delivered to the rodent brain noninvasively, via the nasal cavity. Stem cell--based therapy is predicated on delivering cells to the afflicted part of the body. Researchers now show that there may be an...
- 5From: Nature Methods. (Vol. 6, Issue 10) Peer-ReviewedIn the relatively new field of molecular epigenetics, understanding the dynamics of chromatin is of central importance. In his introduction to the first textbook dedicated to epigenetics, published in 2007, Daniel...
- 6From: Nature Methods. (Vol. 6, Issue 1) Peer-ReviewedScientists create a high-throughput platform for proteome-scale assessment of protein stability. Proteins are the work horses of the cell, and fluctuations in their expression are fundamental for metabolism, cell-cycle...
- 7From: Nature Methods. (Vol. 6, Issue 2) Peer-ReviewedBiobanks collect, store and process human biological specimens and maintain clinical data associated with these samples. The term biobank encompasses both small collections in laboratories or hospitals and large-scale...
- 8From: Nature Methods. (Vol. 6, Issue 2) Peer-ReviewedSuper-resolution imaging methods are advancing rapidly and opening new windows into cellular structure. However, a shortage of genetically encoded photoactivatable and photoswitchable fluorescent probes (PAFPs) still...
- 9From: Nature Methods. (Vol. 6, Issue 6) Peer-ReviewedOrosco et al. describe a two-layer porous silicon nanoreactor as a label-free tool to monitor protease activity. The upper layer contains large pores, which trap the protease. The smaller reaction products filter down...
- 10From: Nature Methods. (Vol. 6, Issue 6) Peer-ReviewedTransposable elements are DNA segments with the unique ability to move about in the genome. This inherent feature can be exploited to harness these elements as gene vectors for genome manipulation. Transposon-based...
- 11From: Nature Methods. (Vol. 6, Issue 3) Peer-ReviewedThe combination of a DNA probe and mass spectrometric analysis allows the unbiased identification of chromatin-associated proteins. Patience does pay off, as Robert Kingston and his postdoctoral fellow Jerome Dejardin...
- 12From: Nature Methods. (Vol. 6, Issue 9) Peer-ReviewedA strategy for selectively disabling activated neurons helps researchers to characterize brain circuitry controlling addiction-related behaviors. Even though decades of research have shown that the familiarity of a...
- 13From: Nature Methods. (Vol. 6, Issue 10) Peer-ReviewedTo the Editor: In photoactivation localization microscopy (PALM), super-resolution imaging is achieved by precise localization of many photoactivatable fluorophores. Image analysis by a fit procedure has so far been much...
- 14From: Nature Methods. (Vol. 6, Issue 1) Peer-ReviewedMethods to reprogram somatic cells to pluripotency have improved and will improve further; more biological studies of these cells are forthcoming. When, a year ago, we picked induced pluripotent (iPS) stem cells as an...
- 15From: Nature Methods. (Vol. 6, Issue 1) Peer-ReviewedA device to cool localized areas of the zebra finch brain allows researchers to investigate how the timing of birdsong is controlled. The zebra finch sings a complex song made up of repeating elements called motifs,...
- 16From: Nature Methods. (Vol. 6, Issue 3) Peer-ReviewedRAD51 plays a central role in homologous recombination. The protein polymerizes around a single-stranded DNA to form a duplex-invading nucleoprotein filament, which then disassembles after strand exchange. van Mameren et...
- 17From: Nature Methods. (Vol. 6, Issue 4) Peer-ReviewedModern biological research methods are powerful tools in biologists' arsenal for investigating biology. But is the ability of these methods to amass extraordinary amounts of data altering the nature of scientific...
- 18From: Nature Methods. (Vol. 6, Issue 7) Peer-ReviewedMicro-optics are increasingly used for minimally invasive in vivo imaging, in miniaturized microscopes and in lab-on-a-chip devices. Owing to optical aberrations and lower numerical apertures, a main class of microlens,...
- 19From: Nature Methods. (Vol. 6, Issue 8) Peer-ReviewedHancock et al. describe the generation of 'designer' enzymes for glycosphingolipid synthesis, using rational mutagenesis-based directed evolution and an enzyme-linked immunoassay (ELISA)-based screen to select...
- 20From: Nature Methods. (Vol. 6, Issue 8) Peer-ReviewedWe developed a digital RNA allelotyping method for quantitatively interrogating allele-specific gene expression. This method involves ultra-deep sequencing of padlock-captured single-nucleotide polymorphisms (SNPs) from...