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- 1From: PLoS Pathogens. (Vol. 6, Issue 10) Peer-ReviewedMicro (mi)RNAs are small non-coding RNAs that regulate the expression of their targets' messenger RNAs through both translational inhibition and regulation of target RNA stability. Recently, a number of viruses,...
- 2From: PLoS Pathogens. (Vol. 6, Issue 10) Peer-ReviewedInfection by DNA viruses can elicit DNA damage responses (DDRs) in host cells. In some cases the DDR presents a block to viral replication that must be overcome, and in other cases the infecting agent exploits the DDR...
- 3From: PLoS Pathogens. (Vol. 6, Issue 10) Peer-ReviewedSocial media consists of Internet technologies that allow users to create and share content, and to foster dialogues among other users. Examples include software applications for communication (blogging, social...
- 4From: PLoS Pathogens. (Vol. 6, Issue 10) Peer-ReviewedFlaviviruses bud into the endoplasmic reticulum and are transported through the secretory pathway, where the mildly acidic environment triggers particle rearrangement and allows furin processing of the prM protein to pr...
- 5From: PLoS Pathogens. (Vol. 6, Issue 10) Peer-ReviewedFrom AD 1347 to AD 1353, the Black Death killed tens of millions of people in Europe, leaving misery and devastation in its wake, with successive epidemics ravaging the continent until the 18th century. The etiology of...
- 6From: PLoS Pathogens. (Vol. 6, Issue 10) Peer-ReviewedHuman adenoviruses from multiple species bind to coagulation factor X (FX), yet the importance of this interaction in adenovirus dissemination is unknown. Upon contact with blood, vectors based on adenovirus serotype 5...
- 7From: PLoS Pathogens. (Vol. 6, Issue 10) Peer-ReviewedThe Encapsidated Viral Genome: What Is Packaged? Retroviral genomic RNAs (gRNAs) are packaged as dimers, joined near their 5' ends in non-covalent linkages that withstand modest heat treatment but dissociate at...
- 8From: PLoS Pathogens. (Vol. 6, Issue 10) Peer-ReviewedWe have developed a high-resolution genomic mapping technique that combines transposon-mediated insertional mutagenesis with either capillary electrophoresis or massively parallel sequencing to identify functionally...
- 9From: PLoS Pathogens. (Vol. 6, Issue 10) Peer-ReviewedIn a screen for RNA mutagen resistance, we isolated a high fidelity RNA dependent RNA polymerase (RdRp) variant of Coxsackie virus B3 (CVB3). Curiously, this variant A372V is also resistant to amiloride. We hypothesize...
- 10From: PLoS Pathogens. (Vol. 6, Issue 10) Peer-ReviewedPrion diseases are fatal neurodegenerative disorders characterized by a long pre-symptomatic phase followed by rapid and progressive clinical phase. Although rare in humans, the unconventional infectious nature of the...
- 11From: PLoS Pathogens. (Vol. 6, Issue 10) Peer-ReviewedThe molecular mechanisms underlying transcriptional regulation in apicomplexan parasites remain poorly understood. Recently, the Apicomplexan AP2 (ApiAP2) family of DNA binding proteins was identified as a major class...
- 12From: PLoS Pathogens. (Vol. 6, Issue 10) Peer-ReviewedT cell receptor (TCR) recognition of peptide-MHC class I (pMHC) complexes is a crucial event in the adaptive immune response to pathogens. Peptide epitopes often display a strong dominance hierarchy, resulting in...
- 13From: PLoS Pathogens. (Vol. 6, Issue 10) Peer-ReviewedAntimicrobial Peptides: Effector Substances of Innate Immunity From the outside and within, we are constantly bombarded with a myriad of diverse microbial species. However, our bodies are equipped with an...
- 14From: PLoS Pathogens. (Vol. 6, Issue 10) Peer-ReviewedCandida albicans is the most common human fungal pathogen, causing infections that can be lethal in immunocompromised patients. Although Saccharomyces cerevisiae has been used as a model for C. albicans, it lacks C....
- 15From: PLoS Pathogens. (Vol. 6, Issue 10) Peer-ReviewedEntry of hepatitis C virus (HCV) into hepatocytes is a multi-step process that involves a number of different host cell factors. Following initial engagement with glycosaminoglycans and the low-density lipoprotein...
- 16From: PLoS Pathogens. (Vol. 6, Issue 10) Peer-ReviewedThe human immunodeficiency virus 1 (HIV-1) transcriptional transactivator (Tat) is essential for synthesis of full- length transcripts from the integrated viral genome by RNA polymerase II (Pol II). Tat recruits the...
- 17From: PLoS Pathogens. (Vol. 6, Issue 10) Peer-ReviewedT cells adopt a polarized morphology in lymphoid organs, where cell-to-cell transmission of HIV-1 is likely frequent. However, despite the importance of understanding virus spread in vivo, little is known about the...
- 18From: PLoS Pathogens. (Vol. 6, Issue 10) Peer-ReviewedIt remains unclear what determines the subcellular localization of hepatitis B virus (HBV) core protein (HBc) and particles. To address this fundamental issue, we have identified four distinct HBc localization signals...
- 19From: PLoS Pathogens. (Vol. 6, Issue 10) Peer-ReviewedA novel, swine-origin influenza H1N1 virus (H1N1pdm) caused the first pandemic of the 21st century. This pandemic, although efficient in transmission, is mild in virulence. This atypical mild pandemic season has raised...
- 20From: PLoS Pathogens. (Vol. 6, Issue 10) Peer-ReviewedCertain pathogens deliver effectors into plant cells to modify host protein targets and thereby suppress immunity. These target modifications can be detected by intracellular immune receptors, or Resistance (R)...