Showing Results for
- Academic Journals (32)
Search Results
- 32
Academic Journals
- 32
- Search Terms:
- 1From: Nature Methods. (Vol. 6, Issue 10) Peer-ReviewedIn the relatively new field of molecular epigenetics, understanding the dynamics of chromatin is of central importance. In his introduction to the first textbook dedicated to epigenetics, published in 2007, Daniel...
- 2From: Nature Methods. (Vol. 6, Issue 10) Peer-ReviewedTo the Editor: In photoactivation localization microscopy (PALM), super-resolution imaging is achieved by precise localization of many photoactivatable fluorophores. Image analysis by a fit procedure has so far been much...
- 3From: Nature Methods. (Vol. 6, Issue 10) Peer-ReviewedThe invariance of C. elegans development allows precise staging and high temporal resolution analysis of embryogenesis (1). However, the small size of the embryo limits the amount of material available for molecular and...
- 4From: Nature Methods. (Vol. 6, Issue 10) Peer-ReviewedThe advent of next-generation sequencing has made possible genome analysis at previously unattainable depth. Roche, Illumina and Life Technologies, among others, have developed well-established platforms for deep...
- 5From: Nature Methods. (Vol. 6, Issue 10) Peer-ReviewedVisualization of choline-containing phospholipids in cells and in vivo is made possible by the metabolic incorporation of a choline analog with an alkyne handle for click chemistry-based labeling. The Cu(I)-catalyzed...
- 6From: Nature Methods. (Vol. 6, Issue 10) Peer-ReviewedIn 1953 virologist John Enders stood before the American Association of Immunologists and began his talk, Tissue Cultures in the Study of Immunity": Retrospection and Anticipation, with an apology. "To construct a...
- 7From: Nature Methods. (Vol. 6, Issue 10) Peer-ReviewedEvolving proteins, evolving tools During the past decade and a half, intrinsically fluorescent proteins have been under intense evolutionary pressure for 'fitness', not in the wild, but rather for utility in live-cell...
- 8From: Nature Methods. (Vol. 6, Issue 10) Peer-ReviewedElectron tomography provides three-dimensional structural information about supramolecular assemblies and organelles in a cellular context, but image degradation, caused by scattering of transmitted electrons, limits...
- 9From: Nature Methods. (Vol. 6, Issue 10) Peer-ReviewedChannelrhodopsin-2 can be efficiently activated by infrared two-photon excitation light and stimulates action potentials in cultured neurons. To understand how the brain works, it is necessary to study neural...
- 10From: Nature Methods. (Vol. 6, Issue 10) Peer-ReviewedTwo groups show that mouse induced pluripotent stem cells (iPSCs) can generate fertile adult mice in tetraploid complementation assays, in which all tissues are derived from the pluripotent cells. Failure to achieve this...
- 11From: Nature Methods. (Vol. 6, Issue 10) Peer-ReviewedCaenorhabditis elegans is one of the most prominent model systems for embryogenesis, but collecting many precisely staged embryos has been impractical. Thus, early C. elegans embryogenesis has not been amenable to most...
- 12From: Nature Methods. (Vol. 6, Issue 10) Peer-ReviewedAlthough Bell Labs is probably best known for game-changing physical sciences breakthroughs such as the laser and the transistor, it has also given neuroscientists considerable cause for gratitude. It was there, in the...
- 13From: Nature Methods. (Vol. 6, Issue 10) Peer-ReviewedDrugs that target pathogenic bacteria or cancer cells can potentially also interfere with human enzyme function. Thus, an understanding of how drugs can affect metabolism is very important. Adams et al. present an online...
- 14From: Nature Methods. (Vol. 6, Issue 10) Peer-ReviewedWe report a proteomics strategy to both identify and quantify cellular target protein interactions with externally introduced ligands. We determined dissociation constants for target proteins interacting with the ligand...
- 15From: Nature Methods. (Vol. 6, Issue 10) Peer-ReviewedWe developed genetically encoded fluorescence resonance energy transfer (FRET)-based sensors that display a large ratiometric change upon [Zn.sup.2+] binding, have affinities that span the pico- to nanomolar range and...
- 16From: Nature Methods. (Vol. 6, Issue 10) Peer-ReviewedBy fusing a light-sensitive domain of an oat plant protein to Rac1, researchers created a genetically encoded protein fusion that can be reversibly activated with blue light and control cell movement--an attractive...
- 17From: Nature Methods. (Vol. 6, Issue 10) Peer-ReviewedThe potential of mass spectrometry-based proteomics to advance biology and biomedicine is nearly unlimited but so is its potential for generating bad data. Apart from the pursuit of technological progress in protocols...
- 18From: Nature Methods. (Vol. 6, Issue 10) Peer-ReviewedThough duplicated regions of the human genome are the culprits of various conditions ranging from color-blindness to lupus, these regions have been very difficult to study. Alkan et al. describe an algorithm called...
- 19From: Nature Methods. (Vol. 6, Issue 10) Peer-ReviewedBiological pathways are structured in complex networks of interacting genes. Solving the architecture of such networks may provide valuable information, such as how microorganisms cause disease. Here we present a method...
- 20From: Nature Methods. (Vol. 6, Issue 10) Peer-ReviewedTo the Editor: The three-dimensional arrangement of chromosomes is critical for genome regulation. Chromosome organization can be studied using chromosome conformation capture (3C)-based assays (1,2). The '3C carbon...