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- Search Terms:ISSN: 1553734XAndISSN: 15537358AndVolume Number: 6AndIssue Number: 1AndStart Page: e1000639AndDate: 2010 Revise Search
- 1From: PLoS Computational Biology. (Vol. 6, Issue 1) Peer-ReviewedCharacterization of the length dependence of end-to-end loop-closure kinetics in unfolded polypeptide chains provides an understanding of early steps in protein folding. Here, loop-closure in poly-glycine-serine...
- 2From: PLoS Computational Biology. (Vol. 6, Issue 1) Peer-ReviewedThe evolutionary dynamics of HIV during the chronic phase of infection is driven by the host immune response and by selective pressures exerted through drug treatment. To understand and model the evolution of HIV...
- 3From: PLoS Computational Biology. (Vol. 6, Issue 1) Peer-ReviewedIntroduction Conferences are important hubs of scientific communication, facilitating networking in ways that traditional methods of remote information dissemination cannot match. Internet-based communication is also...
- 4From: PLoS Computational Biology. (Vol. 6, Issue 1) Peer-ReviewedStudies of the relationship between DNA variation and gene expression variation, often referred to as "expression quantitative trait loci (eQTL) mapping", have been conducted in many species and resulted in many...
- 5From: PLoS Computational Biology. (Vol. 6, Issue 1) Peer-ReviewedPredicting protein structure from primary sequence is one of the ultimate challenges in computational biology. Given the large amount of available sequence data, the analysis of co-evolution, i.e., statistical...
- 6From: PLoS Computational Biology. (Vol. 6, Issue 1) Peer-ReviewedLoss of mitochondrial function is a fundamental determinant of cell injury and death. In heart cells under metabolic stress, we have previously described how the abrupt collapse or oscillation of the mitochondrial...
- 7From: PLoS Computational Biology. (Vol. 6, Issue 1) Peer-ReviewedWe developed a unified model of the GRK-mediated [beta]2 adrenergic receptor ([beta]2AR) regulation that simultaneously accounts for six different biochemical measurements of the system obtained over a wide range of...
- 8From: PLoS Computational Biology. (Vol. 6, Issue 1) Peer-ReviewedIt is widely believed that the modular organization of cellular function is reflected in a modular structure of molecular networks. A common view is that a "module" in a network is a cohesively linked group of nodes,...
- 9From: PLoS Computational Biology. (Vol. 6, Issue 1) Peer-ReviewedBy modelling the average activity of large neuronal populations, continuum mean field models (MFMs) have become an increasingly important theoretical tool for understanding the emergent activity of cortical tissue. In...
- 10From: PLoS Computational Biology. (Vol. 6, Issue 1) Peer-ReviewedEmerging evidence indicates that gene products implicated in human cancers often cluster together in "hot spots" in protein-protein interaction (PPI) networks. Additionally, small sub-networks within PPI networks that...
- 11From: PLoS Computational Biology. (Vol. 6, Issue 1) Peer-ReviewedA basic organizational principle of the primate visual system is that it maps the visual environment repeatedly and retinotopically onto cortex. Simple algebraic models can be used to describe the projection from visual...
- 12From: PLoS Computational Biology. (Vol. 6, Issue 1) Peer-ReviewedThe functional role of synchronization has attracted much interest and debate: in particular, synchronization may allow distant sites in the brain to communicate and cooperate with each other, and therefore may play a...
- 13From: PLoS Computational Biology. (Vol. 6, Issue 1) Peer-ReviewedPerturbation experiments, in which a certain gene is knocked out and the expression levels of other genes are observed, constitute a fundamental step in uncovering the intricate wiring diagrams in the living cell and...
- 14From: PLoS Computational Biology. (Vol. 6, Issue 1) Peer-ReviewedConventional drug design embraces the "one gene, one drug, one disease" philosophy. Polypharmacology, which focuses on multi-target drugs, has emerged as a new paradigm in drug discovery. The rational design of drugs...
- 15From: PLoS Computational Biology. (Vol. 6, Issue 1) Peer-ReviewedMathematical models of mitochondrial bioenergetics provide powerful analytical tools to help interpret experimental data and facilitate experimental design for elucidating the supporting biochemical and physical...
- 16From: PLoS Computational Biology. (Vol. 6, Issue 1) Peer-ReviewedStructural phylogenomics refers to the combined use of evolutionary and structural information in a bioinformatics analysis. The term phylogenomics refers to two distinct tasks: reconstructing a species phylogeny using...
- 17From: PLoS Computational Biology. (Vol. 6, Issue 1) Peer-ReviewedThe persistence of a spatially structured population is determined by the rate of dispersal among habitat patches. If the local dynamic at the subpopulation level is extinction-prone, the system viability is maximal at...
- 18From: PLoS Computational Biology. (Vol. 6, Issue 1) Peer-ReviewedHigh resolution structures of antibody-antigen complexes are useful for analyzing the binding interface and to make rational choices for antibody engineering. When a crystallographic structure of a complex is...
- 19From: PLoS Computational Biology. (Vol. 6, Issue 1) Peer-ReviewedTumorigenesis is a multi-step process in which normal cells transform into malignant tumors following the accumulation of genetic mutations that enable them to evade the growth control checkpoints that would normally...
- 20From: PLoS Computational Biology. (Vol. 6, Issue 1) Peer-ReviewedA wide range of research areas in molecular biology and medical biochemistry require a reliable enzyme classification system, e.g., drug design, metabolic network reconstruction and system biology. When research...