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- 1From: BMC Biophysics. (Vol. 6, Issue 1) Peer-ReviewedBackground Assembly of the ribosome from its protein and RNA constituents must occur quickly and efficiently in order to synthesize the proteins necessary for all cellular activity. Since the early 1960's, certain...
- 2From: BMC Biophysics. (Vol. 6, Issue 1) Peer-ReviewedA recent study by Dietz et al. using single-molecule fluorescence microscopy techniques demonstrates that, in the absence of the ligand InlB, the MET receptor exists as both a monomer and a dimer on the cell membrane,...
- 3From: BMC Biophysics. (Vol. 6, Issue 1) Peer-ReviewedBackground Biomolecules or other complex macromolecules undergo conformational transitions upon exposure to an external perturbation such as ligand binding or mechanical force. To follow fluctuations in pairwise...
- 4From: BMC Biophysics. (Vol. 6, Issue 1) Peer-ReviewedBackground Water is essential for life, but some organisms can survive complete desiccation, while many more survive partial dehydration during drying or freezing. The function of some protective molecules, such as...
- 5From: BMC Biophysics. (Vol. 6, Issue 1) Peer-ReviewedBackground The human receptor tyrosine kinase MET and its ligand hepatocyte growth factor/scatter factor are essential during embryonic development and play an important role during cancer metastasis and tissue...
- 6From: BMC Biophysics. (Vol. 6, Issue 1) Peer-ReviewedBackground Drop drying is a key factor in a wide range of technical applications, including spotted microarrays. The applied nL liquid volume provides specific reaction conditions for the immobilization of probe...
- 7From: BMC Biophysics. (Vol. 6, Issue 1) Peer-ReviewedBackground Intracellular transport is crucial for many cellular processes where a large fraction of the cargo is transferred by motor-proteins over a network of microtubules. Malfunctions in the transport mechanism...
- 8From: BMC Biophysics. (Vol. 6, Issue 1) Peer-ReviewedBackground Fluctuation-induced phenomena caused by both random and deterministic stimuli have been previously studied in a variety of contexts. They are based on the interplay between the spectro-temporal patterns of...
- 9From: BMC Biophysics. (Vol. 6, Issue 1) Peer-ReviewedBackground and objective Regulating protein function in the cell by small molecules, provide a rapid, reversible and tunable tool of metabolic control. However, due to its complexity the issue is poorly studied so...
- 10From: BMC Biophysics. (Vol. 6, Issue 1) Peer-ReviewedBackground Keratins are important structural proteins found in skin, hair and nails. Keratin Intermediate Filaments are major components of corneocytes, nonviable horny cells of the Stratum Corneum, the outermost...
- 11From: BMC Biophysics. (Vol. 6, Issue 1) Peer-ReviewedBackground Lysine Specific Demethylase (LSD1 or KDM1A) in complex with its co-repressor protein CoREST catalyzes the demethylation of the H3 histone N-terminal tail and is currently one of the most promising...
- 12From: BMC Biophysics. (Vol. 6, Issue 1) Peer-ReviewedBackground PQS (Pseudomonas Quinolone Signal) and its precursor HHQ are signal molecules of the P. aeruginosa quorum sensing system. They explicate their role in mammalian pathogenicity by binding to the receptor...
- 13From: BMC Biophysics. (Vol. 6, Issue 1) Peer-ReviewedBackground Increasing applications of titanium dioxide (TiO.sub.2) fine particles (FPs) and nanoparticles (NPs) require coupled knowledge improvement concerning their biokinetic effects. Neutrophils are quickly...
- 14From: BMC Biophysics. (Vol. 6, Issue 1) Peer-ReviewedBackground UV-vis spectrophotometric optical density (OD) is the most commonly-used technique for estimating chromophore formation and cell concentration in liquid culture. OD wavelength is often chosen with little...