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- 1From: Molecular Brain. (Vol. 6, Issue 1) Peer-ReviewedLoss of a sensory input causes the hypersensitivity in other modalities. In addition to cross-modal plasticity, the sensory cortices without receiving inputs undergo the plastic changes. It is not clear how the...
- 2From: Molecular Brain. (Vol. 6, Issue 1) Peer-ReviewedAlzheimer's disease (AD) is a devastating neurodegenerative disorder characterized by loss of memory and cognitive function. A key neuropathological event in AD is the accumulation of amyloid-[beta] (A[beta]) peptide....
- 3From: Molecular Brain. (Vol. 6, Issue 1) Peer-ReviewedRapidly adapting mechanically activated channels (RA) are expressed in primary afferent neurons and identified as Piezo2 ion channels. We made whole-cell voltage-clamp recordings from cultured dorsal root ganglion (DRG)...
- 4From: Molecular Brain. (Vol. 6, Issue 1) Peer-ReviewedBackground GABAergic deficit is one of the major mechanisms underlying epileptic seizures. Previous studies have mainly focused on alterations of synaptic GABAergic inhibition during epileptogenesis. Recent work...
- 5From: Molecular Brain. (Vol. 6, Issue 1) Peer-ReviewedBackground GABA.sub.A receptors are ligand-gated Cl.sup.- channels, and the intracellular Cl.sup.- concentration governs whether GABA function is excitatory or inhibitory. During early brain development, GABA...
- 6From: Molecular Brain. (Vol. 6, Issue 1) Peer-ReviewedBackground Dravet syndrome is a devastating infantile-onset epilepsy syndrome with cognitive deficits and autistic traits caused by genetic alterations in SCN1A gene encoding the [alpha]-subunit of the voltage-gated...
- 7From: Molecular Brain. (Vol. 6, Issue 1) Peer-ReviewedBackground The RNA-binding protein tristetraprolin (TTP) participates in normal post-transcriptional control of cytokine and chemokine gene expression, dysregulation of which contributes to the HIV-associated...
- 8From: Molecular Brain. (Vol. 6, Issue 1) Peer-ReviewedBackground Neuronal activity alters calcium ion (Ca.sup.2+) dynamics in astrocytes, but the physiologic relevance of these changes is controversial. To examine this issue further, we generated an inducible transgenic...
- 9From: Molecular Brain. (Vol. 6, Issue 1) Peer-ReviewedBackground In autosomal recessive early-onset Parkinsonism (PARK2), the pathogenetic process from the loss of function of a ubiquitin ligase parkin to the death of dopamine neurons remains unclear. A dominant...
- 10From: Molecular Brain. (Vol. 6, Issue 1) Peer-ReviewedBackground [alpha]CaMKII plays central and essential roles in long-term potentiation (LTP), learning and memory. [alpha]CaMKII is activated via binding with Ca.sup.2+/CaM in response to elevated Ca.sup.2+...
- 11From: Molecular Brain. (Vol. 6, Issue 1) Peer-ReviewedBackground The selective serotonin reuptake inhibitor fluoxetine (FLX) is widely used totreat depression and anxiety disorders, but cellular mechanisms underlyingthe antidepressant effect of FLX remain largely...
- 12From: Molecular Brain. (Vol. 6, Issue 1) Peer-ReviewedBackground Neuropeptides are a diverse category of signaling molecules in the nervous system regulating a variety of processes including food intake, social behavior, circadian rhythms, learning, and memory. Both the...
- 13From: Molecular Brain. (Vol. 6, Issue 1) Peer-ReviewedBackground Several etiological reports have shown that chronic pain significantly interferes with sleep. Inadequate sleep due to chronic pain may contribute to the stressful negative consequences of living with pain....
- 14From: Molecular Brain. (Vol. 6, Issue 1) Peer-ReviewedBackground Sensory input is generally thought to be necessary for refining and consolidating neuronal connections during brain development. We here report that cortical callosal axons in somatosensory cortex require...
- 15From: Molecular Brain. (Vol. 6, Issue 1) Peer-ReviewedBackground Silver nanoparticles (AgNPs), owing to their effective antimicrobial properties, are being widely used in a broad range of applications. These include, but are not limited to, antibacterial materials, the...
- 16From: Molecular Brain. (Vol. 6, Issue 1) Peer-ReviewedA consensus has famously yet to emerge on the locus and mechanisms underlying the expression of the canonical NMDA receptor-dependent form of LTP. An objective assessment of the evidence leads us to conclude that both...
- 17From: Molecular Brain. (Vol. 6, Issue 1) Peer-ReviewedBackground Bergmann glia (BG) are unipolar cerebellar astrocytes. The somata of mature BG reside in the Purkinje cell layer and extend radially arranged processes to the pial surface. BG have multiple branched...
- 18From: Molecular Brain. (Vol. 6, Issue 1) Peer-ReviewedBackground Type B GABA receptors (GABA Rs) play a critical role in synaptic transmission. We carried out studies to determine whether neuronal cell surface expression of GABAB-Rs might be regulated by the Nogo...
- 19From: Molecular Brain. (Vol. 6, Issue 1) Peer-ReviewedBackground A long non-coding RNA (lncRNA), nuclear-enriched abundant transcript 1_2 (NEAT1_2), constitutes nuclear bodies known as "paraspeckles". Mutations of RNA binding proteins, including TAR DNA-binding...
- 20From: Molecular Brain. (Vol. 6, Issue 1) Peer-ReviewedBackground Spinocerebellar ataxia type 1 (SCA1) is a genetic disorder characterized by severe ataxia associated with progressive loss of cerebellar Purkinje cells. The mGlu1 metabotropic glutamate receptor plays a...