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- Search Terms:ISSN: 15537390AndISSN: 15537404AndVolume Number: 5AndIssue Number: 9AndStart Page: e1000635AndDate: 2009 Revise Search
- 1From: PLoS Genetics. (Vol. 5, Issue 9) Peer-ReviewedThe tumor suppressor p53 has been implicated in multiple functions that play key roles in health and disease, including ribosome biogenesis, control of aging, and cell cycle regulation. A genetic screen for negative...
- 2From: PLoS Genetics. (Vol. 5, Issue 9) Peer-ReviewedThe epigenetic regulation of gene expression by the covalent modification of histones is a fundamental mechanism required for the proper differentiation of germ line cells during development. Trimethylation of histone 3...
- 3From: PLoS Genetics. (Vol. 5, Issue 9) Peer-ReviewedAlpha satellite domains that currently function as centromeres of human chromosomes are flanked by layers of older alpha satellite, thought to contain dead centromeres of primate progenitors, which lost their function...
- 4From: PLoS Genetics. (Vol. 5, Issue 9) Peer-ReviewedBalanced maternal and paternal genome contributions are a requirement for successful seed development. Unbalanced contributions often cause seed abortion, a phenomenon that has been termed "triploid block."...
- 5From: PLoS Genetics. (Vol. 5, Issue 9) Peer-ReviewedWe recently showed that cassette integration and deletion in integron platforms were occurring through unconventional site-specific recombination reactions involving only the bottom strand of attC sites. The lack of...
- 6From: PLoS Genetics. (Vol. 5, Issue 9) Peer-ReviewedMeiotic recombination is initiated by the formation of numerous DNA double-strand breaks (DSBs) catalysed by the widely conserved Spo11 protein. In Saccharomyces cerevisiae, Spo11 requires nine other proteins for...
- 7From: PLoS Genetics. (Vol. 5, Issue 9) Peer-ReviewedHeart failure, the clinical syndrome that arises from inadequate cardiac pump function, is known to be influenced by genetic factors. However, thus far unbiased genetic approaches in humans have met with limited success...
- 8From: PLoS Genetics. (Vol. 5, Issue 9) Peer-ReviewedResection of DNA double-strand break (DSB) ends is generally considered a critical determinant in pathways of DSB repair and genome stability. Unlike for enzymatically induced site-specific DSBs, little is known about...
- 9From: PLoS Genetics. (Vol. 5, Issue 9) Peer-Reviewed
Segregating YKU80 and TLC1 alleles underlying natural variation in telomere properties in wild yeast
In yeast, as in humans, telomere length varies among individuals and is controlled by multiple loci. In a quest to define the extent of variation in telomere length, we screened 112 wild-type Saccharomyces sensu siricio... - 10From: PLoS Genetics. (Vol. 5, Issue 9) Peer-ReviewedFor gene products that must be present in cells at defined concentrations, expression levels must be tightly controlled to ensure robustness against environmental, genetic, and developmental noise. By studying the...
- 11From: PLoS Genetics. (Vol. 5, Issue 9) Peer-ReviewedThe Arabidopsis ARGONAUTE1 (AGO1) and ZWILLE/PINHEAD/AGO10 (ZLL) proteins act in the miRNA and siRNA pathways and are essential for multiple processes in development. Here, we analyze what determines common and specific...
- 12From: PLoS Genetics. (Vol. 5, Issue 9) Peer-ReviewedThe Bae, Cpx, Psp, Rcs, and [[sigma].sup.E] pathways constitute the Escherichia coli signaling systems that detect and respond to alterations of the bacterial envelope. Contributions of these systems to stress response...
- 13From: PLoS Genetics. (Vol. 5, Issue 9) Peer-ReviewedNatural genetic variation in Arabidopsis thaliana exists for many traits and often reflects acclimation to local environments. Studying natural variation has proven valuable in the characterization of phenotypic traits...
- 14From: PLoS Genetics. (Vol. 5, Issue 9) Peer-ReviewedSegmentation of the vertebrate body axis is initiated through Somitogenesis, whereby epithelial Somites bud off in pairs periodically from the rostral end of the unsegmented presomitic mesoderm (PSM). The periodicity of...
- 15From: PLoS Genetics. (Vol. 5, Issue 9) Peer-ReviewedA follow-up study of a large Utah family with significant linkage to chromosome 2g24 led us to identify a new febrile seizure (FS) gene, SCN9A encoding [Na.sub.v]1.7. In 21 affected members, we uncovered a potential...
- 16From: PLoS Genetics. (Vol. 5, Issue 9) Peer-ReviewedWhen Caenorhabditis elegans encounters an unfavourable stimulus at its anterior, it responds by initiating an avoidance response, namely reversal of locomotion. The amphid neurons, ASHL and ASHR, are polymodal in...
- 17From: PLoS Genetics. (Vol. 5, Issue 9) Peer-ReviewedAtaxia represents a pathological coordination failure that often involves functional disturbances in cerebellar circuits. Purkinje cells (PCs) characterize the only output neurons of the cerebellar cortex and critically...
- 18From: PLoS Genetics. (Vol. 5, Issue 9) Peer-ReviewedOnce upon a time, not so very long ago, before restriction enzymes were ordered from a New England Biolabs catalog and vectors arrived in neat packages from Promega, and before molecular biologists added patents or a...
- 19From: PLoS Genetics. (Vol. 5, Issue 9) Peer-ReviewedMyopia is one of the most common ocular disorders worldwide. Pathological myopia, also called high myopia, comprises 1% to 5% of the general population and is one of the leading causes of legal blindness in developed...
- 20From: PLoS Genetics. (Vol. 5, Issue 9) Peer-ReviewedVestigial structures occur at both the anatomical and molecular levels, but studies documenting the co-occurrence of morphological degeneration in the fossil record and molecular decay in the genome are rare. Here, we...