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- 1From: PLoS Genetics. (Vol. 5, Issue 8) Peer-ReviewedCurrent genome-wide association studies (GWAS) are moving towards the use of large cohorts of primary cell lines to study a disease of interest and to assign biological relevance to the genetic signals identified. Here,...
- 2From: PLoS Genetics. (Vol. 5, Issue 8) Peer-ReviewedPollen tubes extend through pistil tissues and are guided to ovules where they release sperm for fertilization. Although pollen tubes can germinate and elongate in a synthetic medium, their trajectory is random and...
- 3From: PLoS Genetics. (Vol. 5, Issue 8) Peer-ReviewedAlternative pre-mRNA splicing adjusts the transcriptional output of the genome by generating related mRNAs from a single primary transcript, thereby expanding protein diversity. A fundamental unanswered question is how...
- 4From: PLoS Genetics. (Vol. 5, Issue 8) Peer-ReviewedMonomethyl branched-chain fatty acids (mmBCFAs) are essential for Caenorhabditis elegans growth and development. To identify factors acting downstream of mmBCFAs for their function in growth regulation, we conducted a...
- 5From: PLoS Genetics. (Vol. 5, Issue 8) Peer-ReviewedEpigenetic control of gene transcription is critical for normal human development and cellular differentiation. While alterations of epigenetic marks such as DNA methylation have been linked to cancers and many other...
- 6From: PLoS Genetics. (Vol. 5, Issue 8) Peer-ReviewedMany organisms have a mechanism for down regulating the expression of non-synapsed chromosomes and chromosomal regions during meiosis. This phenomenon is thought to function in genome defense. During early meiosis in...
- 7From: PLoS Genetics. (Vol. 5, Issue 8) Peer-ReviewedMutations affecting the maintenance of heritable epigenetic states in maize identify multiple RNA-directed DNA methylation (RdDM) factors including RMR1, a novel member of a plant-specific clade of Snf2-related...
- 8From: PLoS Genetics. (Vol. 5, Issue 8) Peer-ReviewedInsulin/insulin-like growth factor signaling (IIS) plays a pivotal role in the regulation of growth at the cellular and the organismal level during animal development. Flies with impaired IIS are developmentally delayed...
- 9From: PLoS Genetics. (Vol. 5, Issue 8) Peer-ReviewedNutrition is known to interact with genotype in human metabolic syndromes, obesity, and diabetes, and also in Drosophila metabolism. Plasticity in metabolic responses, such as changes in body fat or blood sugar in...
- 10From: PLoS Genetics. (Vol. 5, Issue 8) Peer-ReviewedThe checkpoint kinases ATM and ATR are redundantly required for maintenance of stable telomeres in diverse organisms, including budding and fission yeasts, Arabidopsis, Drosophila, and mammals. However, the molecular...
- 11From: PLoS Genetics. (Vol. 5, Issue 8) Peer-ReviewedBacterial transposons are known to move to new genomic sites using either a replicative or a conservative mechanism. The behavior of transposon Tn5 is anomalous. In vitro studies indicate that it uses a conservative...
- 12From: PLoS Genetics. (Vol. 5, Issue 8) Peer-ReviewedPsoriasis is a common inflammatory skin disease characterized by thickened scaly red plaques. Previously we have performed a genome-wide association study (GWAS) on psoriasis with 1,359 cases and 1,400 controls, which...
- 13From: PLoS Genetics. (Vol. 5, Issue 8) Peer-ReviewedAnalysis of polymorphism and divergence in the non-coding portion of the human genome yields crucial information about factors driving the evolution of gene regulation. Candidate cis-regulatory regions spanning more...
- 14From: PLoS Genetics. (Vol. 5, Issue 8) Peer-ReviewedTranscription elongation by RNA polymerase II was often considered an invariant non-regulated process. However, genomewide studies have shown that transcriptional pausing during elongation is a frequent phenomenon in...
- 15From: PLoS Genetics. (Vol. 5, Issue 8) Peer-ReviewedKashin-Beck disease, a syndrome characterized by short stature, skeletal deformities, and arthropathy of multiple joints, is highly prevalent in specific regions of Asia. The disease has been postulated to result from a...
- 16From: PLoS Genetics. (Vol. 5, Issue 8) Peer-ReviewedHuman FTO gene variants are associated with body mass index and type 2 diabetes. Because the obesity-associated SNPs are intronic, it is unclear whether changes in FTO expression or splicing are the cause of obesity or...
- 17From: PLoS Genetics. (Vol. 5, Issue 8) Peer-ReviewedWith only ~3,000 wild individuals surviving restricted to just 7% of their historical range, tigers are now a globally threatened species. Therefore, conservation efforts must prioritize regions that harbor more tigers,...
- 18From: PLoS Genetics. (Vol. 5, Issue 8) Peer-ReviewedIn most sexually reproducing organisms, the fundamental process of meiosis is implemented concurrently with two differentiation programs that occur at different rates and generate distinct cell types, sperm and oocytes....
- 19From: PLoS Genetics. (Vol. 5, Issue 8) Peer-ReviewedIn Saccharomyces cerevisiae, the conserved phosphatase Cdc14 is required for the exit from mitosis. It is anchored on nucleolar chromatin by the Cfi1/Net1 protein until early anaphase, at which time it is released into...
- 20From: PLoS Genetics. (Vol. 5, Issue 8) Peer-ReviewedIn bacteria, recombination is a rare event, not a part of the reproductive process. Nevertheless, recombination--broadly defined to include the acquisition of genes from external sources, i.e., horizontal gene transfer...