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- Search Terms:ISSN: 15537366AndISSN: 15537374AndVolume Number: 5AndIssue Number: 8AndStart Page: e1000560AndDate: 2009 Revise Search
- 1From: PLoS Pathogens. (Vol. 5, Issue 8) Peer-ReviewedHepatitis E virus (HEV), a non-enveloped, positive-stranded RNA virus, is transmitted in a faecal-oral manner, and causes acute liver diseases in humans. The HEV capsid is made up of capsomeres consisting of homodimers...
- 2From: PLoS Pathogens. (Vol. 5, Issue 8) Peer-ReviewedAssembly and disassembly of viral capsids are essential steps in the viral life cycle. Studies on their kinetics are mostly performed in vitro, allowing application of biochemical, biophysical and visualizing...
- 3From: PLoS Pathogens. (Vol. 5, Issue 8) Peer-ReviewedRecognition of conserved bacterial components provides immediate and efficient immune responses and plays a critical role in triggering antigen-specific adaptive immunity. To date, most microbial components that are...
- 4From: PLoS Pathogens. (Vol. 5, Issue 8) Peer-ReviewedPseudomonas aeruginoso is an opportunistic human pathogen that causes infections in a variety of animal and plant hosts. Caenorhabditis elegans is a simple model with which one can identify bacterial virulence genes....
- 5From: PLoS Pathogens. (Vol. 5, Issue 8) Peer-ReviewedChlamydia trachomatis (CT) infection is one of the most common causes of reproductive tract diseases and infertility. CT-Hsp60 is synthesized during infection and is released in the bloodstream. As a consequence, immune...
- 6From: PLoS Pathogens. (Vol. 5, Issue 8) Peer-ReviewedIn a recent paper in Science, Lund et al. [1] investigated the effect of regulatory T cells (Tregs) on the antiviral immune response to an acute herpes virus infection. Previous studies on the role of Tregs in different...
- 7From: PLoS Pathogens. (Vol. 5, Issue 8) Peer-ReviewedPlant NB-LRR proteins confer robust protection against microbes and metazoan parasites by recognizing pathogen-derived avirulence (Avr) proteins that are delivered to the host cytoplasm. Microbial Avr proteins usually...
- 8From: PLoS Pathogens. (Vol. 5, Issue 8) Peer-Reviewed[CD4.sup.+][CD25.sup.+][Foxp3.sup.+] regulatory T cells (Tregs) regulate disease-associated immunity and excessive inflammatory responses, and numbers of [CD4.sup.+][CD25.sup.+][Foxp3.sup.+] Tregs are increased during...
- 9From: PLoS Pathogens. (Vol. 5, Issue 8) Peer-ReviewedGiardia intestinalis is a major cause of diarrheal disease worldwide and two major Giardia genotypes, assemblages A and B, infect humans. The genome of assemblage A parasite WB was recently sequenced, and the...
- 10From: PLoS Pathogens. (Vol. 5, Issue 8) Peer-ReviewedViruses are obligate intracellular parasites and therefore their replication completely depends on host cell factors. In case of the hepatitis C virus (HCV), a positive-strand RNA virus that in the majority of...
- 11From: PLoS Pathogens. (Vol. 5, Issue 8) Peer-Reviewed
Two HIV-1 variants resistant to small molecule CCR5 inhibitors differ in how they use CCR5 for entry
HIV-1 variants resistant to small molecule CCR5 inhibitors recognize the inhibitor-CCR5 complex, while also interacting with free CCR5. The most common genetic route to resistance involves sequence changes in the gpl20... - 12From: PLoS Pathogens. (Vol. 5, Issue 8) Peer-ReviewedThe ability to respond to stress is at the core of an organism's survival. The hormones epinephrine and norepinephrine play a central role in stress responses in mammals, which require the synchronized interaction of...
- 13From: PLoS Pathogens. (Vol. 5, Issue 8) Peer-ReviewedMalaria parasites must undergo sexual and sporogonic development in mosquitoes before they can infect their vertebrate hosts. We report the discovery and characterization of MISFIT, the first protein with paternal...
- 14From: PLoS Pathogens. (Vol. 5, Issue 8) Peer-ReviewedAll natural Leishmania infections start in the skin; however, little is known of the contribution made by the sand fly vector to the earliest events in mammalian infection, especially in inflamed skin that can rapidly...
- 15From: PLoS Pathogens. (Vol. 5, Issue 8) Peer-ReviewedDNA methylation of retroviral promoters and enhancers localized in the provirus 59 long terminal repeat (LTR) is considered to be a mechanism of transcriptional suppression that allows retroviruses to evade host immune...
- 16From: PLoS Pathogens. (Vol. 5, Issue 8) Peer-ReviewedRecognition of conserved bacterial products by innate immune receptors leads to inflammatory responses that control pathogen spread but that can also result in pathology. Intestinal epithelial cells are exposed to...
- 17From: PLoS Pathogens. (Vol. 5, Issue 8) Peer-ReviewedAfrican swine fever virus (ASFV), like other complex DNA viruses, deploys a variety of strategies to evade the host's defence systems, such as inflammatory and immune responses and cell death. Here, we analyse the...
- 18From: PLoS Pathogens. (Vol. 5, Issue 8) Peer-ReviewedThe emergence of drug resistance in microbial pathogens provides a poignant example of an evolutionary process with a profound impact on human health. Fungal drug resistance poses a particular concern given the limited...
- 19From: PLoS Pathogens. (Vol. 5, Issue 8) Peer-ReviewedPrion diseases are fatal neurodegenerative disorders causing motor dysfunctions, dementia and neuropathological changes such as spongiosis, astroglyosis and neuronal loss. The chain of events leading to the clinical...
- 20From: PLoS Pathogens. (Vol. 5, Issue 8) Peer-ReviewedFluoroquinolones are antibacterial drugs that inhibit DNA Gyrase and Topoisomerase IV. These essential enzymes facilitate chromosome replication and RNA transcription by regulating chromosome supercoiling. High-level...