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- Search Terms:ISSN: 1553734XAndISSN: 15537358AndVolume Number: 5AndIssue Number: 8AndStart Page: e1000467AndDate: 2009 Revise Search
- 1From: PLoS Computational Biology. (Vol. 5, Issue 8) Peer-ReviewedThe asymmetric cell division cycle of Caulobacter crescentus is orchestrated by an elaborate gene-protein regulatory network, centered on three major control proteins, DnaA, GcrA and CtrA. The regulatory network is cast...
- 2From: PLoS Computational Biology. (Vol. 5, Issue 8) Peer-ReviewedInjury to nerve axons induces diverse responses in neuronal cell bodies, some of which are influenced by the distance from the site of injury. This suggess that neurons have the capacity to estimate the distance of the...
- 3From: PLoS Computational Biology. (Vol. 5, Issue 8) Peer-ReviewedProteins frequently accomplish their biological function by collective atomic motions. Yet the identification of collective motions related to a specific protein function from, e.g., a molecular dynamics trajectory is...
- 4From: PLoS Computational Biology. (Vol. 5, Issue 8) Peer-ReviewedBrains were built by evolution to react swiftly to environmental challenges. Thus, sensory stimuli must be processed ad hoc, i.e., independent-to a large extent-from the momentary brain state incidentally prevailing...
- 5From: PLoS Computational Biology. (Vol. 5, Issue 8) Peer-ReviewedLactase persistence (LP) is common among people of European ancestry, but with the exception of some African, Middle Eastern and southern Asian groups, is rare or absent elsewhere in the world. Lactase gene haplotype...
- 6From: PLoS Computational Biology. (Vol. 5, Issue 8) Peer-ReviewedCytotoxic T lymphocytes (CTLs) are important immune effectors against intra-cellular pathogens. These cells search for infected cells and kill them. Recently developed experimental methods in combination with...
- 7From: PLoS Computational Biology. (Vol. 5, Issue 8) Peer-ReviewedThe epidermal growth factor receptor (EGFR) signaling pathway is probably the best-studied receptor system in mammalian cells, and it also has become a popular example for employing mathematical modeling to cellular...
- 8From: PLoS Computational Biology. (Vol. 5, Issue 8) Peer-ReviewedThe brain's decoding of fast sensory streams is currently impossible to emulate, even approximately, with artificial agents. For example, robust speech recognition is relatively easy for humans but exceptionally...
- 9From: PLoS Computational Biology. (Vol. 5, Issue 8) Peer-ReviewedMolecular chaperones are essential elements of the protein quality control machinery that governs translocation and folding of nascent polypeptides, refolding and degradation of misfolded proteins, and activation of a...
- 10From: PLoS Computational Biology. (Vol. 5, Issue 8) Peer-ReviewedThe dissociation mechanism of the thioredoxin (Trx) mixed disulfide complexes is unknown and has been debated for more than twenty years. Specifically, opposing arguments for the activation of the nucleophilic cysteine...
- 11From: PLoS Computational Biology. (Vol. 5, Issue 8) Peer-ReviewedThe three-dimensional structures of proteins are stabilized by the interactions between amino acid residues. Here we report a method where four distances are calculated between any two side chains to provide an exact...
- 12From: PLoS Computational Biology. (Vol. 5, Issue 8) Peer-ReviewedIn allosteric regulation, an effector molecule binding a protein at one site induces conformational changes, which alter structure and function at a distant active site. Two key challenges in the computational modeling...
- 13From: PLoS Computational Biology. (Vol. 5, Issue 8) Peer-ReviewedThe mechanisms by which adaptive phenotypes spread within an evolving population after their emergence are understood fairly well. Much less is known about the factors that influence the evolutionary accessibility of...
- 14From: PLoS Computational Biology. (Vol. 5, Issue 8) Peer-ReviewedPrecise patterning of morphogen molecules and their accurate reading out are of key importance in embryonic development. Recent experiments have visualized distributions of proteins in developing embryos and shown that...
- 15From: PLoS Computational Biology. (Vol. 5, Issue 8) Peer-ReviewedNanoparticles introduced in living cells are capable of strongly promoting the aggregation of peptides and proteins. We use here molecular dynamics simulations to characterise in detail the process by which nanoparticle...
- 16From: PLoS Computational Biology. (Vol. 5, Issue 8) Peer-ReviewedUnderstanding complex networks of protein-protein interactions (PPIs) is one of the foremost challenges of the postgenomic era. Due to the recent advances in experimental bio-technology, including yeast-2-hybrid (Y2H),...
- 17From: PLoS Computational Biology. (Vol. 5, Issue 8) Peer-ReviewedSmall molecule drugs target many core metabolic enzymes in humans and pathogens, often mimicking endogenous ligands. The effects may be therapeutic or toxic, but are frequently unexpected. A large-scale mapping of the...
- 18From: PLoS Computational Biology. (Vol. 5, Issue 8) Peer-ReviewedMetabolism is central to cell physiology, and metabolic disturbances play a role in numerous disease states. Despite its importance, the ability to study metabolism at a global scale using genomic technologies is...
- 19From: PLoS Computational Biology. (Vol. 5, Issue 8) Peer-ReviewedIn both prokaryotic and eukaryotic cells, gene expression is regulated across the cell cycle to ensure" just-in-time" assembly of select cellular structures and molecular machines. However, present in all time-series...
- 20From: PLoS Computational Biology. (Vol. 5, Issue 8) Peer-ReviewedProgress in science depends on the effective exchange of ideas among scientists. New ideas can be assessed and criticized in a meaningful manner only if they are formulated precisely. This applies to simulation studies...