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- 1From: Nature Methods. (Vol. 5, Issue 8) Peer-ReviewedSufficient oxygen supply is essential for proper function of all energy-consuming processes during the cell cycle. Oxygen limitation results in slow growth and production kinetics. Effective aeration during cell...
- 2From: Nature Methods. (Vol. 5, Issue 8) Peer-ReviewedBy engineering magnetic microstructures, researchers demonstrate the potential for multiplexed MRI. In optical imaging experiments, researchers can take advantage of different colored fluorophores to track different...
- 3From: Nature Methods. (Vol. 5, Issue 8) Peer-ReviewedIdentification of higher-order oligomers in the plasma membrane is essential to decode the properties of molecular networks controlling intercellular communication. We combined bioluminescence resonance energy transfer...
- 4From: Nature Methods. (Vol. 5, Issue 8) Peer-ReviewedThe ability to perform complex bioassays in parallel enables experiments that are otherwise impossible because of throughput and cost constraints. For example, highly parallel chemical-genetic screens using pooled...
- 5From: Nature Methods. (Vol. 5, Issue 8) Peer-ReviewedAt the American Society for Mass Spectrometry (ASMS) meeting in June 2008, mass spectrometry instrumentation aimed at identification of protein biomarkers--proteins indicative of a disease or disease state--appeared to...
- 6From: Nature Methods. (Vol. 5, Issue 8) Peer-ReviewedUsing chemically assembled ubiquitylated histone H2B, researchers demonstrate that direct cross-talk results in methylation of a lysine on another histone. Post-translational modification of histone proteins is a...
- 7From: Nature Methods. (Vol. 5, Issue 8) Peer-ReviewedWe used two new coral fluorescent proteins as fluorescence resonance energy transfer (FRET) donor and acceptor to develop a voltage sensor, named Mermaid, that displays ~ 40% changes in emission ratio per 100 mV,...
- 8From: Nature Methods. (Vol. 5, Issue 8) Peer-ReviewedVibrio cholerae is the water-borne microorganism responsible for cholera. To facilitate genome-wide screening of gene function in this pathogen, Cameron et al. report the creation of a near-saturation transposon...
- 9From: Nature Methods. (Vol. 5, Issue 8) Peer-ReviewedNext-generation DNA sequencing technologies are facilitating rapid and low-cost sequencing of whole genomes. The enormous volume of sequencing data, however, has presented a huge data management challenge, especially in...
- 10From: Nature Methods. (Vol. 5, Issue 8) Peer-ReviewedAlthough the highly dynamic and mosaic organization of the plasma membrane is well-recognized, depicting a resolved, global view of this organization remains challenging. We present an analytical single-particle tracking...
- 11From: Nature Methods. (Vol. 5, Issue 8) Peer-ReviewedOngoing efforts show promise in replacing reprogramming factors with small molecules for making induced pluripotent stem cells. The discovery that scmiatic cells can be reverted to a pluripotent state has electrified...
- 12From: Nature Methods. (Vol. 5, Issue 8) Peer-ReviewedWe describe a system that permits the automated analysis of reporter gene expression in Caenorhabditis elegans with cellular resolution continuously during embryogenesis. We demonstrate its utility by defining the...
- 13From: Nature Methods. (Vol. 5, Issue 8) Peer-ReviewedVisEn Medical has developed FMT™ 2544, a quantitative fluorescence molecular tomographic system useful for rapid, noninvasive measurement of disease biology in living animals. This imaging technology, paired with one of...
- 14From: Nature Methods. (Vol. 5, Issue 8) Peer-ReviewedSingle-particle tracking (SPT) is often the rate-limiting step in live-cell imaging studies of subcellular dynamics. Here we present a tracking algorithm that addresses the principal challenges of SPT, namely high...
- 15From: Nature Methods. (Vol. 5, Issue 8) Peer-ReviewedNext-generation sequencing-based studies locate nucleosomes at high resolution throughout several genomes. DNA is packaged into cells by being wrapped around histones to form nucleosomes, which are spaced periodically...
- 16From: Nature Methods. (Vol. 5, Issue 8) Peer-ReviewedA new protein tag simplifies labeling and visualization of newly synthesized target proteins in tissue and whole animals. The creation and maintenance of cellular structures relies on regulated expression and spatial...
- 17From: Nature Methods. (Vol. 5, Issue 8) Peer-ReviewedA central challenge in neuroscience is to understand the formation and function of three-dimensional (3D) neuronal networks. In vitro studies have been mainly limited to measurements of small numbers of neurons connected...
- 18From: Nature Methods. (Vol. 5, Issue 8) Peer-ReviewedResearchers demonstrate a method for observing intact membrane protein complexes by mass spectrometry. Most scientists are probably familiar with the application of mass spectrometry to proteomics or for analyzing...
- 19From: Nature Methods. (Vol. 5, Issue 8) Peer-ReviewedFunctional genomic studies in Saccharomyces cerevisiae have contributed enormously to our understanding of cellular processes. Their full potential, however, has been hampered by the limited availability of reagents to...
- 20From: Nature Methods. (Vol. 5, Issue 8) Peer-ReviewedWe are creating families of designer G protein-coupled receptors (GPCRs) to a allow for precise spatiotemporal control of GPCR signaling in vivo. These engineered GPCRs, called receptors activated solely by synthetic...