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- 1From: Nature Reviews Genetics. (Vol. 5, Issue 8) Peer-ReviewedAuthor(s): Nick Campbell The enthusiasm for the diagnostic potential of DNA microarray technology has been huge despite an almost total absence of baseline data on variation in gene-expression patterns in normal...
- 2From: Nature Reviews Genetics. (Vol. 5, Issue 8) Peer-ReviewedAuthor(s): Nick Campbell A new study of expression patterns of key developmental genes in an anemone indicates that the phylum Cnidaria has been unfairly excluded from the 'family' of bilaterally symmetrical animals...
- 3From: Nature Reviews Genetics. (Vol. 5, Issue 8) Peer-ReviewedAuthor(s): Louisa Flintoft The United Kingdom's Medical Research Council (MRC) has announced public funding of £1.5 million towards a new centre for stem-cell research. "This funding comes at a critical juncture ......
- 4From: Nature Reviews Genetics. (Vol. 5, Issue 8) Peer-ReviewedAuthor(s): David J. Weatherall [1] Thalassaemias are a group of disorders that are caused by defective and imbalanced globin production. More than 200 mutations in β-globin genes lead to β-thalassaemias, whereas more...
- 5From: Nature Reviews Genetics. (Vol. 5, Issue 8) Peer-ReviewedAuthor(s): Eldon E. Ball (corresponding author) [1]; David C. Hayward (corresponding author) [1]; Robert Saint [1]; David J. Miller [2] Thanks to the application of powerful molecular genetic tools to a few 'model'...
- 6From: Nature Reviews Genetics. (Vol. 5, Issue 8) Peer-ReviewedAuthor(s): Blake C. Meyers [1]; Simone Scalabrin [2, 3]; Michele Morgante (corresponding author) [2] The construction of a whole-genome physical map has been an essential component of numerous genome projects initiated...
- 7From: Nature Reviews Genetics. (Vol. 5, Issue 8) Peer-ReviewedAuthor(s): Lin He; Gregory J Hannon Nature Reviews Genetics 5, 522-531 (2004) In figure 2, the orientation of some RNA structures was incorrect. The corrected version is shown below. This correction has been made to...
- 8From: Nature Reviews Genetics. (Vol. 5, Issue 8) Peer-ReviewedAuthor(s): Tanita Casci A genetic study of a family of transcription factors has thrown up a surprising link between circadian genes and epilepsy, thanks to some knockout transgenic mice and the fortuitous...
- 9From: Nature Reviews Genetics. (Vol. 5, Issue 8) Peer-ReviewedAuthor(s): Magdalena Skipper There are some fundamental processes in biology that we would expect to be conserved across all phyla. And yet some of them use a surprising variety of molecular mechanisms. A recent...
- 10From: Nature Reviews Genetics. (Vol. 5, Issue 8) Peer-ReviewedAuthor(s): Christopher Surridge [1] Homeotic genes are central to the control of morphogenesis. But are they switches, initiating a programme of gene expression that proceeds without their further guidance, or do...
- 11From: Nature Reviews Genetics. (Vol. 5, Issue 8) Peer-ReviewedKnowledge of inherited genetic variation has a fundamental impact on understanding human disease. Unfortunately, our understanding of the functional significance of many inherited genetic variants is limited. New...
- 12From: Nature Reviews Genetics. (Vol. 5, Issue 8) Peer-ReviewedPublic demand and the development of large public and private databases of genetic information across human populations has encouraged the development of the new and rapidly growing field of genetic ancestry testing....
- 13From: Nature Reviews Genetics. (Vol. 5, Issue 8) Peer-ReviewedFunctional Genomics Integration of transcriptomics and metabolomics for understanding of global responses to nutritional stresses in Arabidopsis thaliana . Hirai, M. Y. et al . Proc. Natl Acad. Sci. USA 15 June...
- 14From: Nature Reviews Genetics. (Vol. 5, Issue 8) Peer-ReviewedInteractions among loci or between genes and environmental factors make a substantial contribution to variation in complex traits such as disease susceptibility. Nonetheless, many studies that attempt to identify the...
- 15From: Nature Reviews Genetics. (Vol. 5, Issue 8) Peer-ReviewedAuthor(s): Chris Gunter [1] It is the question that everyone is asking: we have the completed genome sequence -- now how do we use it effectively? In the case of the mouse, one answer lies in high-throughput...
- 16From: Nature Reviews Genetics. (Vol. 5, Issue 8) Peer-ReviewedAuthor(s): Tanita Casci Mothers, it would seem, were designed to meddle in our affairs right from the word go, as maternal gene products direct many embryonic processes before zygotic transcription gets going. To...
- 17From: Nature Reviews Genetics. (Vol. 5, Issue 8) Peer-ReviewedThe success of many strategies for finding genetic variants that underlie complex traits depends on how genetic variation is distributed among human populations. This realization has intensified the investigation of...
- 18From: Nature Reviews Genetics. (Vol. 5, Issue 8) Peer-ReviewedAuthor(s): Alison Rowan Whether you are a home-loving, faithful type or more of a Casanova could be further from your control than you might think. Reporting in Nature , Lim and colleagues elegantly show that the...
- 19From: Nature Reviews Genetics. (Vol. 5, Issue 8) Peer-ReviewedChromosome Biology Regulation of murine telomere length by Rtel : an essential gene encoding a helicase-like protein . Ding, H. & Scherter, M. et al . Cell 17, 873-886 (2004) Telomere lengths vary between...
- 20From: Nature Reviews Genetics. (Vol. 5, Issue 8) Peer-ReviewedAuthor(s): Magdalena Skipper Polyglutamine (polyQ) repeat expansions are involved in several human disorders, perhaps the most famous among them being Huntington disease (HD). The HD gene was cloned in 1993, and...