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- 1From: PLoS Genetics. (Vol. 5, Issue 7) Peer-ReviewedIn species with large effective population sizes, highly expressed genes tend to be encoded by codons with highly abundant cognate tRNAs to maximize translation rate. However, there has been little evidence for a...
- 2From: PLoS Genetics. (Vol. 5, Issue 7) Peer-ReviewedElongator is a six subunit protein complex, conserved from yeast to humans. Mutations in the human Elongator homologue, hELP1, are associated with the neurological disease familial dysautonomia. However, how Elongator...
- 3From: PLoS Genetics. (Vol. 5, Issue 7) Peer-ReviewedDrosophila NURF is an ISWI-containing chromatin remodeling complex that catalyzes ATP-dependent nucleosome sliding. By sliding nucleosomes, NURF can alter chromatin structure and regulate transcription. NURF301/BPTF is...
- 4From: PLoS Genetics. (Vol. 5, Issue 7) Peer-ReviewedPLoS Genetics is different: different not only because of the PLoS-wide vision for open access and new ways of communicating science, but also in terms of administration and leadership. We are, first and foremost, a...
- 5From: PLoS Genetics. (Vol. 5, Issue 7) Peer-ReviewedSteroid hormones regulate gene expression by interaction of their receptors with hormone responsive elements (HREs) and recruitment of kinases, chromatin remodeling complexes, and coregulators to their target promoters....
- 6From: PLoS Genetics. (Vol. 5, Issue 7) Peer-ReviewedResistance (R) protein--associated pathways are well known to participate in defense against a variety of microbial pathogens. Salicylic acid (SA) and its associated proteinaceous signaling components, including...
- 7From: PLoS Genetics. (Vol. 5, Issue 7) Peer-ReviewedApert syndrome is almost always caused by a spontaneous mutation of paternal origin in one of two nucleotides in the fibroblast growth factor receptor 2 gene (FGFR2). The incidence of this disease increases with the age...
- 8From: PLoS Genetics. (Vol. 5, Issue 7) Peer-ReviewedAge-related cataract is a major cause of blindness worldwide, and cortical cataract is the second most prevalent type of age-related cataract. Although a significant fraction of age-related cataract is heritable, the...
- 9From: PLoS Genetics. (Vol. 5, Issue 7) Peer-ReviewedPch2 is a widely conserved protein that is required in baker's yeast for the organization of meiotic chromosome axes into specific domains. We provide four lines of evidence suggesting that it regulates the formation...
- 10From: PLoS Genetics. (Vol. 5, Issue 7) Peer-ReviewedI have known Pat Brown for about two decades and he never ceases to amaze me. Over the years, I have heard him speak quite a few times, and on each occasion I can feel my jaw drop. What will he think up next? Pat...
- 11From: PLoS Genetics. (Vol. 5, Issue 7) Peer-ReviewedHair follicles undergo recurrent cycling of controlled growth (anagen), regression (catagen), and relative quiescence (telogen) with a defined periodicity. Taking a genomics approach to study gene expression during...
- 12From: PLoS Genetics. (Vol. 5, Issue 7) Peer-ReviewedGermline mutations in the adenomatous polyposis coli (APC) gene are responsible for familial adenomatous polyposis (FAP), an autosomal dominant hereditary predisposition to the development of multiple colorectal...
- 13From: PLoS Genetics. (Vol. 5, Issue 7) Peer-ReviewedIn nature, closely related species may hybridize while still retaining their distinctive identities. Chromosomal regions that experience reduced recombination in hybrids, such as within inversions, have been...
- 14From: PLoS Genetics. (Vol. 5, Issue 7) Peer-ReviewedThe aberrant expression of the transmembrane protein EpCAM is associated with tumor progression, affecting different cellular processes such as cell-cell adhesion, migration, proliferation, differentiation, signaling,...
- 15From: PLoS Genetics. (Vol. 5, Issue 7) Peer-ReviewedNuclear receptors of the Hepatocyte Nuclear Factor-4 (HNF4) subtype have been linked to a host of developmental and metabolic functions in animals ranging from worms to humans; however, the full spectrum of...
- 16From: PLoS Genetics. (Vol. 5, Issue 7) Peer-ReviewedIntroduction Much of the public media discussion of genetics of common diseases has centered on opportunities for targeted preventive actions. At the same time, in the specialist literature, there has been extensive...
- 17From: PLoS Genetics. (Vol. 5, Issue 7) Peer-ReviewedIn human somatic tumorigenesis, mutations are thought to arise sporadically in individual cells surrounded by unaffected cells. This contrasts with most current transgenic models where mutations are induced...
- 18From: PLoS Genetics. (Vol. 5, Issue 7) Peer-ReviewedTrf4p and Trf5p are non-canonical poly(A) polymerases and are part of the heteromeric protein complexes TRAMP4 and TRAMP5 that promote the degradation of aberrant and short-lived RNA substrates by interacting with the...
- 19From: PLoS Genetics. (Vol. 5, Issue 7) Peer-ReviewedMost of the somatic cells of adult metazoans, including mammals, do not undergo continuous cycles of replication. Instead, they are quiescent and devote most of their metabolic activity to gene expression. The mutagenic...
- 20From: PLoS Genetics. (Vol. 5, Issue 7) Peer-ReviewedWater striders, a group of semi-aquatic bugs adapted to life on the water surface, have evolved mid-legs (L2) that are long relative to their hind-legs (L3). This novel appendage ground plan is a derived feature among...