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- 1From: PLoS Pathogens. (Vol. 5, Issue 7) Peer-ReviewedThe cyst wall of Entamoeba invadens (Ei), a model for the human pathogen Entamoeba histolytica, is composed of fibrils of chitin and three chitin-binding lectins called Jacob, Jessie3, and chitinase. Here we show...
- 2From: PLoS Pathogens. (Vol. 5, Issue 7) Peer-ReviewedGenes required for infection of mice by Salmonella Typhimurium can be identified by the interrogation of random transposon mutant libraries for mutants that cannot survive in vivo. Inactivation of such genes produces...
- 3From: PLoS Pathogens. (Vol. 5, Issue 7) Peer-ReviewedHost defense against the intracellular protozoan parasite Trypanosoma cruzi depends on Toll-like receptor (TLR)-dependent innate immune responses. Recent studies also suggest the presence of TLR-independent responses to...
- 4From: PLoS Pathogens. (Vol. 5, Issue 7) Peer-ReviewedPrevious studies identified prion protein (PrP) mutants which act as dominant negative inhibitors of prion formation through a mechanism hypothesized to require an unidentified species-specific cofactor termed protein...
- 5From: PLoS Pathogens. (Vol. 5, Issue 7) Peer-ReviewedLEDGF/p75 can tether over-expressed lentiviral integrase proteins to chromatin but how this underlies its integration cofactor role for these retroviruses is unclear. While a single integrase binding domain (IBD) binds...
- 6From: PLoS Pathogens. (Vol. 5, Issue 7) Peer-ReviewedPools of mutants of minimal complexity but maximal coverage of genes of interest facilitate screening for genes under selection in a particular environment. We constructed individual deletion mutants in 1,023 Salmonella...
- 7From: PLoS Pathogens. (Vol. 5, Issue 7) Peer-ReviewedPlant Resistance (R) proteins play an integral role in defense against pathogen infection. A unique gain-of-function mutation in the R gene SNC1, snc1, results in constitutive activation of plant immune pathways and...
- 8From: PLoS Pathogens. (Vol. 5, Issue 7) Peer-ReviewedThe envelope (E) protein from coronaviruses is a small polypeptide that contains at least one [alpha]-helical transmembrane domain. Absence, or inactivation, of E protein results in attenuated viruses, due to...
- 9From: PLoS Pathogens. (Vol. 5, Issue 7) Peer-ReviewedRep68 is a multifunctional protein of the adeno-associated virus (AAV), a parvovirus that is mostly known for its promise as a gene therapy vector. In addition to its role as initiator in viral DNA replication, Rep68 is...
- 10From: PLoS Pathogens. (Vol. 5, Issue 7) Peer-ReviewedHuman APOBEC3G inhibits the replication of Vif-deficient HIV-1 by hypermutating nascent viral cDNA (reviewed in [1-3]). Zheng and colleagues recently reported that the HIV-1 restriction activity of APOBEC3G requires a...
- 11From: PLoS Pathogens. (Vol. 5, Issue 7) Peer-ReviewedTicks are serious haematophagus arthropod pests and are only second to mosquitoes as vectors of diseases of humans and animals. The salivary glands of the slower feeding hard ticks such as Haernaphysolis longicornis are...
- 12From: PLoS Pathogens. (Vol. 5, Issue 7) Peer-ReviewedDelivery of effector proteins is a process widely used by bacterial pathogens to subvert host cell functions and cause disease. Effector delivery is achieved by elaborate injection devices and can often be triggered by...
- 13From: PLoS Pathogens. (Vol. 5, Issue 7) Peer-ReviewedProgrammed necrosis is a mechanism of cell death that has been described for neuronal excitotoxicity and ischemia/ reperfusion injury, but has not been extensively studied in the context of exposure to bacterial...
- 14From: PLoS Pathogens. (Vol. 5, Issue 7) Peer-Reviewedp53-signaling is modulated by viruses to establish a host cellular environment advantageous for their propagation. The Epstein-Barr virus (EBV) lytic program induces phosphorylation of p53, which prevents interaction...
- 15From: PLoS Pathogens. (Vol. 5, Issue 7) Peer-ReviewedAmong Caliciviridae, the norovirus genus encompasses enteric viruses that infect humans as well as several animal species, causing gastroenteritis. Porcine strains are classified together with human strains within...
- 16From: PLoS Pathogens. (Vol. 5, Issue 7) Peer-ReviewedCandida albicans is the leading fungal pathogen of humans, causing life-threatening disease in immunocompromised individuals. Treatment of candidiasis is hampered by the limited number of antifungal drugs whose efficacy...
- 17From: PLoS Pathogens. (Vol. 5, Issue 7) Peer-ReviewedThe paramyxoviruses are a family of negative-sense RNA viruses that includes many important human and animal pathogens. Paramyxovirus RNA synthesis requires the viral phosphoprotein (P) and the large (L) protein....
- 18From: PLoS Pathogens. (Vol. 5, Issue 7) Peer-ReviewedPeptide inhibitors derived from HIV-gp41 envelope protein play a pivotal role in deciphering the molecular mechanism of HIV-cell fusion. According to accepted models, N-heptad repeat (NHR) peptides can bind two targets...
- 19From: PLoS Pathogens. (Vol. 5, Issue 7) Peer-ReviewedThe genome of Epstein-Barr virus (EBV) encodes 86 proteins, but only a limited set is expressed in EBV-growth transformed B cells, termed lymphoblastoid cell lines (LCLs). These cells proliferate via the concerted...
- 20From: PLoS Pathogens. (Vol. 5, Issue 7) Peer-ReviewedIn July and September 2007, miners working in Kitaka Cave, Uganda, were diagnosed with Marburg hemorrhagic fever. The likely source of infection in the cave was Egyptian fruit bats (Rousettus aegyptiacus) based on...