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- 1From: PLoS Neglected Tropical Diseases. (Vol. 5, Issue 6) Peer-ReviewedBackground: Podoconiosis is an environmental lymphoedema affecting people living and working barefoot on irritant red clay soil. Podoconiosis is relatively well described in southern Ethiopia, but remains neglected in...
- 2From: PLoS Neglected Tropical Diseases. (Vol. 5, Issue 6) Peer-ReviewedLeishmania infantum (syn. L. chagasi) is the causative agent of visceral leishmaniasis (VL) in the New World (NW) with endemic regions extending from southern USA to northern Argentina. The two hypotheses about the...
- 3From: PLoS Neglected Tropical Diseases. (Vol. 5, Issue 6) Peer-ReviewedBackground: The Kato-Katz thick smear (Kato-Katz) is the diagnostic method recommended for monitoring large-scale treatment programs implemented for the control of soil-transmitted helminths (STH) in public health, yet...
- 4From: PLoS Neglected Tropical Diseases. (Vol. 5, Issue 6) Peer-ReviewedThe human gut parasite Entamoeba histolytica, uses a lectin complex on its cell surface to bind to mucin and to ligands on the intestinal epithelia. Binding to mucin is necessary for colonisation and binding to...
- 5From: PLoS Neglected Tropical Diseases. (Vol. 5, Issue 6) Peer-ReviewedBackground: Trypanosoma brucei brucei infects livestock, with severe effects in horses and dogs. Mouse strains differ greatly in susceptibility to this parasite. However, no genes controlling these differences were...
- 6From: PLoS Neglected Tropical Diseases. (Vol. 5, Issue 6) Peer-ReviewedBackground: Rabies is a fatal encephalitis caused by lyssaviruses. Evidence of lyssavirus circulation has recently emerged in Southeast Asian bats. A cross-sectional study was conducted in Thailand to assess...
- 7From: PLoS Neglected Tropical Diseases. (Vol. 5, Issue 6) Peer-ReviewedPlasmodium vivax malaria is a debilitating, sometimes life-threatening, and economically repressive disease of many tropical and temperate countries outside Africa, and yet it is perceived as relatively benign. The...
- 8From: PLoS Neglected Tropical Diseases. (Vol. 5, Issue 6) Peer-ReviewedTrachoma is the leading infectious cause of blindness worldwide, and responsible for the loss of an estimated 1.3 million disability-adjusted life years, mainly in sub-Saharan Africa [1]. Geographically, trachoma is a...
- 9From: PLoS Neglected Tropical Diseases. (Vol. 5, Issue 6) Peer-ReviewedBackground: Leishmania (Viannia) parasites present particular challenges, as human and murine immune responses to infection are distinct from other Leishmania species, indicating a unique interaction with the host....
- 10From: PLoS Neglected Tropical Diseases. (Vol. 5, Issue 6) Peer-ReviewedHumans who experience a primary dengue virus (DENV) infection develop antibodies that preferentially neutralize the homologous serotype responsible for infection. Affected individuals also generate cross-reactive...
- 11From: PLoS Neglected Tropical Diseases. (Vol. 5, Issue 6) Peer-ReviewedBackground: Chronic soil-transmitted helminth (STH) infections are associated with effects on systemic immune responses that could be caused by alterations in immune homeostasis. To investigate this, we measured the...
- 12From: PLoS Neglected Tropical Diseases. (Vol. 5, Issue 6) Peer-ReviewedBackground: Dengue fever is reemerging on the island of Martinique and is a serious threat for the human population. During dengue epidemics, adult Aedes aegypti control with pyrethroid space sprays is implemented in...
- 13From: PLoS Neglected Tropical Diseases. (Vol. 5, Issue 6) Peer-ReviewedNeurocysticercosis (NCC) is a major cause of epilepsy in regions where pigs are free-ranging and hygiene is poor. Pork production is expected to increase in the next decade in sub-Saharan Africa, hence NCC will likely...
- 14From: PLoS Neglected Tropical Diseases. (Vol. 5, Issue 6) Peer-ReviewedBackground: Serological tests for IgM and IgG are routinely used in clinical laboratories for the rapid diagnosis of dengue and can differentiate between primary and secondary infections. Dengue virus non-structural...
- 15From: PLoS Neglected Tropical Diseases. (Vol. 5, Issue 6) Peer-ReviewedBackground: This study aims to estimate the age-specific risks of clinical dengue attack (i.e., the risk of symptomatic dengue among the total number of dengue virus (DENV) infections) during primary and secondary...
- 16From: PLoS Neglected Tropical Diseases. (Vol. 5, Issue 6) Peer-ReviewedBackground: The peak shift model predicts that the age-profile of a pathogen's prevalence depends upon its transmission rate, peaking earlier in populations with higher transmission and declining as partial immunity is...
- 17From: PLoS Neglected Tropical Diseases. (Vol. 5, Issue 6) Peer-ReviewedBackground: Loiasis is a major obstacle to ivermectin treatment for onchocerciasis control and lymphatic filariasis elimination in central Africa. In communities with a high level of loiasis endemicity, there is a...
- 18From: PLoS Neglected Tropical Diseases. (Vol. 5, Issue 6) Peer-Reviewed
SCYX-7158, an orally-active benzoxaborole for the treatment of stage 2 human African trypanosomiasis
Background: Human African trypanosomiasis (HAT) is an important public health problem in sub-Saharan Africa, affecting hundreds of thousands of individuals. An urgent need exists for the discovery and development of... - 19From: PLoS Neglected Tropical Diseases. (Vol. 5, Issue 6) Peer-ReviewedBackground: The aim of this study was to investigate the relationship between prior Anisakis infections and upper gastrointestinal bleeding (UGIB), and its interaction with non-steroidal anti-inflammatory drug (NSAID)...
- 20From: PLoS Neglected Tropical Diseases. (Vol. 5, Issue 6) Peer-ReviewedPercutaneous treatment (PT) emerged in the mid-1980s as an alternative to surgery for selected cases of abdominal cystic echinococcosis (CE). Despite its efficacy and widespread use, the puncture of echinococcal cysts...