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- Search Terms:ISSN: 15537390AndISSN: 15537404AndVolume Number: 5AndIssue Number: 6AndStart Page: e1000537AndDate: 2009 Revise Search
- 1From: PLoS Genetics. (Vol. 5, Issue 6) Peer-ReviewedThe genetics underlying the autism spectrum disorders (ASDs) is complex and remains poorly understood. Previous work has demonstrated an important role for structural variation in a subset of cases, but has lacked the...
- 2From: PLoS Genetics. (Vol. 5, Issue 6) Peer-ReviewedGenetic redundancy, whereby two genes carry out seemingly overlapping functions, may in large part be attributable to the intricacy and robustness of genetic networks that control many developmental processes. We have...
- 3From: PLoS Genetics. (Vol. 5, Issue 6) Peer-ReviewedOur previous genome-wide linkage analysis identified a susceptibility locus for generalized vitiligo on 22g12. To search for susceptibility genes within the locus, we investigated a biological candidate gene, X-box...
- 4From: PLoS Genetics. (Vol. 5, Issue 6) Peer-ReviewedElevated serum uric acid levels cause gout and are a risk factor for cardiovascular disease and diabetes. To investigate the polygenetic basis of serum uric acid levels, we conducted a meta-analysis of genome-wide...
- 5From: PLoS Genetics. (Vol. 5, Issue 6) Peer-ReviewedCentral abdominal fat is a strong risk factor for diabetes and cardiovascular disease. To identify common variants influencing central abdominal fat, we conducted a two-stage genome-wide association analysis for waist...
- 6From: PLoS Genetics. (Vol. 5, Issue 6) Peer-ReviewedThe [[PSI.sup.+]] prion may enhance evolvability by revealing previously cryptic genetic variation, but it is unclear whether such evolvability properties could be favored by natural selection. Sex inhibits the...
- 7From: PLoS Genetics. (Vol. 5, Issue 6) Peer-ReviewedHorizontal acquisition of DNA by bacteria dramatically increases genetic diversity and hence successful bacterial colonization of several niches, including the human host. A relevant issue is how this newly acquired DNA...
- 8From: PLoS Genetics. (Vol. 5, Issue 6) Peer-ReviewedVarious observations argue for a role of adaptation in recent human evolution, including results from genome-wide studies and analyses of selection signals at candidate genes. Here, we use genome-wide SNP data from the...
- 9From: PLoS Genetics. (Vol. 5, Issue 6) Peer-ReviewedFilamentous fungi grow as extending and branching tubular cells (hyphae) that generate radially symmetric colonies. As colonies expand, hyphal tips at the periphery avoid each other to allow maximum coverage of the...
- 10From: PLoS Genetics. (Vol. 5, Issue 6) Peer-ReviewedNeural stem cell self-renewal, neurogenesis, and cell fate determination are processes that control the generation of specific classes of neurons at the correct place and time. The transcription factor Pax6 is essential...
- 11From: PLoS Genetics. (Vol. 5, Issue 6) Peer-ReviewedA crucial step in the development of muscle cells in all metazoan animals is the assembly and anchorage of the sarcomere, the essential repeat unit responsible for muscle contraction. In Caenorhabditis elegans, many of...
- 12From: PLoS Genetics. (Vol. 5, Issue 6) Peer-ReviewedPeroxiredoxins (Prxs) constitute a family of thiol-specific peroxidases that utilize cysteine (Cys) as the primary site of oxidation during the reduction of peroxides. To gain more insight into the physiological role of...
- 13From: PLoS Genetics. (Vol. 5, Issue 6) Peer-ReviewedTranslating a set of disease regions into insight about pathogenic mechanisms requires not only the ability to identify the key disease genes within them, but also the biological relationships among those key genes....
- 14From: PLoS Genetics. (Vol. 5, Issue 6) Peer-ReviewedEukaryotic organelles evolve to support the lifestyle of evolutionarily related organisms. In the fungi, filamentous Ascomycetes possess dense-core organelles called Woronin bodies (WBs). These organelles originate from...
- 15From: PLoS Genetics. (Vol. 5, Issue 6) Peer-Reviewed
In vivo generation of neurotoxic prion protein: role for Hsp70 in accumulation of misfolded isoforms
Prion diseases are incurable neurodegenerative disorders in which the normal cellular prion protein ([PrP.sup.C]) converts into a misfolded isoform ([PrP.sup.Sc]) with unique biochemical and structural properties that... - 16From: PLoS Genetics. (Vol. 5, Issue 6) Peer-ReviewedGenotype imputation methods are now being widely used in the analysis of genome-wide association studies. Most imputation analyses to date have used the HapMap as a reference dataset, but new reference panels (such as...
- 17From: PLoS Genetics. (Vol. 5, Issue 6) Peer-ReviewedRare copy number variants (CNVs) are frequently associated with common neurological disorders such as mental retardation (MR; learning disability), autism, and schizophrenia. CNV screening in clinical practice is...
- 18From: PLoS Genetics. (Vol. 5, Issue 6) Peer-ReviewedRates of spontaneous mutation have been estimated under optimal growth conditions for a variety of DNA-based microbes, including viruses, bacteria, and eukaryotes. When expressed as genomic mutation rates, most of the...
- 19From: PLoS Genetics. (Vol. 5, Issue 6) Peer-ReviewedDeleterious mutations inevitably emerge in any evolutionary process and are speculated to decisively influence the structure of the genome. Meiosis, which is thought to play a major role in handling mutations on the...
- 20From: PLoS Genetics. (Vol. 5, Issue 6) Peer-ReviewedDamage initiates a pleiotropic cellular response aimed at cellular survival when appropriate. To identify genes required for damage survival, we used a cell-based RNAi screen against the Drosophila genome and the...