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- 1From: Nature Reviews Microbiology. (Vol. 5, Issue 5) Peer-ReviewedOne of the defining characteristics of vertebrate immunity is the development of an adaptive immune response to an invading pathogen. By contrast, it was thought that the immune system of invertebrates was completely...
- 2From: Nature Reviews Microbiology. (Vol. 5, Issue 5) Peer-ReviewedExclusive breastfeeding until a baby is 6-months old can minimize the frequency of mother-to-child HIV transmission according to researchers in South Africa. Exclusive breastfeeding carried a 4% risk of postnatal...
- 3From: Nature Reviews Microbiology. (Vol. 5, Issue 5) Peer-ReviewedThe cystic fibrosis (CF) superbug Burkholderia cenocepacia could be killed by drugs that interfere with 4-amino-4-deoxy-L-arabinose (Ara4N) synthesis, according to research teams from Ontario and Edinburgh. The B....
- 4From: Nature Reviews Microbiology. (Vol. 5, Issue 5) Peer-ReviewedAbstract | Diverse pathogenic bacteria have developed similar mechanisms to subvert host cell responses. In this Progress article, we focus on bacterial virulence factors with different enzymatic activities that can...
- 5From: Nature Reviews Microbiology. (Vol. 5, Issue 5) Peer-ReviewedA 2-year-old boy was admitted to a Chicago hospital on 3 March after developing eczema vaccinatum. The child suffered the reaction after contact with his father, who had recently been vaccinated against smallpox as part...
- 6From: Nature Reviews Microbiology. (Vol. 5, Issue 5) Peer-ReviewedProteogenomics--the combination of community genomics and proteomics--enables researchers to link community functions to specific member microorganisms. Building on a previous proteogenomics study that detailed the...
- 7From: Nature Reviews Microbiology. (Vol. 5, Issue 5) Peer-ReviewedChanging antimalarial strategies is not straightforward, as the outcome of switching from chloroquine to artemisinin-based combination therapy (ACT) in Zambia has shown. Poor delivery of the new therapy was prevalent in...
- 8From: Nature Reviews Microbiology. (Vol. 5, Issue 5) Peer-ReviewedWhen bacteria are starved, the stringent response coordinates cell functions to divert scarce resources from growth and cell division to amino-acid biosynthesis in order to aid survival. Publishing in Cell, Wang et al....
- 9From: Nature Reviews Microbiology. (Vol. 5, Issue 5) Peer-ReviewedYersinia pestis has caused small outbreaks of bubonic plague worldwide and is also classed as a bioterrorism threat. In 1995 a Y. pestis strain resistant to multiple antibiotics that contained a self-transmissible...
- 10From: Nature Reviews Microbiology. (Vol. 5, Issue 5) Peer-ReviewedThe transition metal gallium could be a promising new therapeutic agent against Pseudomonas aeruginosa infections, according to a report published recently in the Journal of Clinical Investigation. The chronic P....
- 11From: Nature Reviews Microbiology. (Vol. 5, Issue 5) Peer-ReviewedLarge-scale genomic surveys of microbial communities are currently expanding massively in number, scope and pace. Recent genomic forays into complex microbial communities include acid-mine drainage sites (1), symbiotic...
- 12From: Nature Reviews Microbiology. (Vol. 5, Issue 5) Peer-ReviewedThe host ubiquitination pathway is a key point of regulation for various cellular processes, and so is an obvious target for subversion by both bacterial and viral pathogens. Previous work using a functional proteomics...
- 13From: Nature Reviews Microbiology. (Vol. 5, Issue 5) Peer-ReviewedThe middle-ear infection otitis media (OM) is one of the most commonly diagnosed diseases of early childhood, with Streptococcus pneumoniae being one of the most common bacterial pathogens associated with this disease....
- 14From: Nature Reviews Microbiology. (Vol. 5, Issue 5) Peer-ReviewedGlaxoSmithKline PLC is starting the registration process for a vaccine that is unlikely to make the company any money. Globorix is a combination vaccine that will protect against Neisseria meningitidis serogroups A and...
- 15From: Nature Reviews Microbiology. (Vol. 5, Issue 5) Peer-ReviewedAbstract | The Tad (tight adherence) macromolecular transport system, which is present in many bacterial and archaeal species, represents an ancient and major new subtype of type II secretion. The tad genes are present...
- 16From: Nature Reviews Microbiology. (Vol. 5, Issue 5) Peer-ReviewedDNA evidence from ancient skeletal remains attests to the presence of tuberculosis in the earliest human societies. A recent study published in Microbiology describes the first report of Mycobacterium bovis DNA present...
- 17From: Nature Reviews Microbiology. (Vol. 5, Issue 5) Peer-ReviewedThe Ziehl-Neelsen stain, which was developed in the late 1800s, is routinely used to diagnose TB, particularly in developing countries. This reliable test uses a phenol-based stain that penetrates cells but cannot be...
- 18From: Nature Reviews Microbiology. (Vol. 5, Issue 5) Peer-ReviewedAlteri and colleagues present ultrastructural, biochemical and genetic data indicating that the causative agent of tuberculosis, Mycobacterium tuberculosis, produces pili during human infection. Transmission electron...
- 19From: Nature Reviews Microbiology. (Vol. 5, Issue 5) Peer-ReviewedAvian influenza. Another three people died from avian 'flu in Indonesia, bringing the death toll in that country to 69. Three children also had avian 'flu in Egypt, which has now had 32 human cases and a new fatal case...
- 20From: Nature Reviews Microbiology. (Vol. 5, Issue 5) Peer-ReviewedAbstract | In all organisms, multi-subunit replicases are responsible for the accurate duplication of genetic material during cellular division. Initiator proteins control the onset of DNA replication and direct the...