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- 1From: PLoS Genetics. (Vol. 5, Issue 5) Peer-ReviewedSegregation Distorter (SD) is a selfish, coadapted gene complex on chromosome 2 of Drosophila melanogaster that strongly distorts Mendelian transmission; heterozygous SD/SD' males sire almost exclusively SD-bearing...
- 2From: PLoS Genetics. (Vol. 5, Issue 5) Peer-ReviewedThe shoot apical meristem (SAM) maintains a pool of indeterminate cells within the SAM proper, while lateral organs are initiated from the SAM periphery. Laser microdissection-microarray technology was used to compare...
- 3From: PLoS Genetics. (Vol. 5, Issue 5) Peer-ReviewedDNA double-strand breaks (DSBs) are a common form of cellular damage that can lead to cell death if not repaired promptly. Experimental systems have shown that DSB repair in eukaryotic cells is often imperfect and may...
- 4From: PLoS Genetics. (Vol. 5, Issue 5) Peer-ReviewedMyotonic dystrophy type 1 (DM1) is associated with one of the most highly unstable CTG*CAG repeat expansions. The formation of further repeat expansions in transgenic mice carrying expanded CTG*CAG tracts requires the...
- 5From: PLoS Genetics. (Vol. 5, Issue 5) Peer-ReviewedGenome duplications increase genetic diversity and may facilitate the evolution of gene subfunctions. Little attention, however, has focused on the evolutionary impact of lineage-specific gene loss. Here, we show that...
- 6From: PLoS Genetics. (Vol. 5, Issue 5) Peer-ReviewedTelomere capture, a rare event that stabilizes chromosome breaks, is associated with certain genetic abnormalities in humans. Studies pertaining to the generation, maintenance, and biological effects of telomere...
- 7From: PLoS Genetics. (Vol. 5, Issue 5) Peer-ReviewedDietary restriction (DR) extends lifespan in various species and also slows the onset of age-related diseases. Previous studies from flies and yeast have demonstrated that the target of rapamycin (TOR) pathway is...
- 8From: PLoS Genetics. (Vol. 5, Issue 5) Peer-ReviewedIn budding yeast, the Pif1 DNA helicase is involved in the maintenance of both nuclear and mitochondrial genomes, but its role in these processes is still poorly understood. Here, we provide evidence for a new Pif1...
- 9From: PLoS Genetics. (Vol. 5, Issue 5) Peer-ReviewedCaloric restriction extends lifespan, an effect once thought to involve attenuation of reactive oxygen species (ROS) generated by aerobic metabolism. However, recent evidence suggests that caloric restriction may in...
- 10From: PLoS Genetics. (Vol. 5, Issue 5) Peer-ReviewedThe p53 tumor suppressor regulates its target genes through sequence-specific binding to DNA response elements (RES). Although numerous p53 RES are established, the thousands more identified by bioinformatics are not...
- 11From: PLoS Genetics. (Vol. 5, Issue 5) Peer-ReviewedChromosomal instability, which involves the deletion and duplication of chromosomes or chromosome parts, is a common feature of cancers, and deficiency screens are commonly used to detect genes involved in various...
- 12From: PLoS Genetics. (Vol. 5, Issue 5) Peer-ReviewedThe organization of eukaryotic genomes is characterized by the presence of distinct euchromatic and heterochromatic subnuclear compartments. In Saccharomyces cerevisiae heterochromatic loci, including telomeres and...
- 13From: PLoS Genetics. (Vol. 5, Issue 5) Peer-ReviewedThe prevalence of obesity (body mass index (BMI) [greater than or equal to]30 kg/[m.sup.2]) is higher in African Americans than in European Americans, even after adjustment for socioeconomic factors, suggesting that...
- 14From: PLoS Genetics. (Vol. 5, Issue 5) Peer-ReviewedThe haplotype map constructed by the HapMap Project is a valuable resource in the genetic studies of disease genes, population structure, and evolution. In the Project, Caucasian and African haplotypes are fairly...
- 15From: PLoS Genetics. (Vol. 5, Issue 5) Peer-ReviewedComparative genomics can be used to infer the history of genomic rearrangements that occurred during the evolution of a species. We used the principle of parsimony, applied to aligned synteny blocks from 11 yeast...
- 16From: PLoS Genetics. (Vol. 5, Issue 5) Peer-ReviewedCopy number variations (CNVs) represent a large source of genetic variation in humans and have been increasingly studied for disease association. A deletion polymorphism of the gene encoding the cytosolic detoxification...
- 17From: PLoS Genetics. (Vol. 5, Issue 5) Peer-ReviewedSensory ataxic neuropathy (SAN) is a recently identified neurological disorder in golden retrievers. Pedigree analysis revealed that all affected dogs belong to one maternal lineage, and a statistical analysis showed...
- 18From: PLoS Genetics. (Vol. 5, Issue 5) Peer-ReviewedIn recent years, the advent of high-throughput assays, coupled with their diminishing cost, has facilitated a systems approach to biology. As a consequence, massive amounts of data are currently being generated,...
- 19From: PLoS Genetics. (Vol. 5, Issue 5) Peer-ReviewedThough central to our understanding of how roots perform their vital function of scavenging water and solutes from the soil, no direct genetic evidence currently exists to support the foundational model that suberin...
- 20From: PLoS Genetics. (Vol. 5, Issue 5) Peer-ReviewedSome 12 years ago, Wolfe and colleagues demonstrated that Saccharomyces cerevisiae is the descendant of an ancient whole-genome duplication event [1,2], much to the consternation of many of those who had recently...