Showing Results for
- Academic Journals (24)
Search Results
- 24
Academic Journals
- 24
- Search Terms:
- 1From: PLoS Computational Biology. (Vol. 5, Issue 5) Peer-ReviewedWe describe a new program for the alignment of multiple biological sequences that is both statistically motivated and fast enough for problem sizes that arise in practice. Our Fast Statistical Alignment program is based...
- 2From: PLoS Computational Biology. (Vol. 5, Issue 5) Peer-ReviewedPush-pull networks, in which two antagonistic enzymes control the activity of a messenger protein, are ubiquitous in signal transduction pathways. A classical example is the chemotaxis system of the bacterium...
- 3From: PLoS Computational Biology. (Vol. 5, Issue 5) Peer-ReviewedRobust oscillatory behaviors are common features of circadian and cell cycle rhythms. These cyclic processes, however, behave distinctively in terms of their periods and phases in response to external influences such as...
- 4From: PLoS Computational Biology. (Vol. 5, Issue 5) Peer-ReviewedBiphasic neural response properties, where the optimal stimulus for driving a neural response changes from one stimulus pattern to the opposite stimulus pattern over short periods of time, have been described in several...
- 5From: PLoS Computational Biology. (Vol. 5, Issue 5) Peer-Reviewed[alpha]-actinin is an actin crosslinking molecule that can serve as a scaffold and maintain dynamic actin filament networks. As a crosslinker in the stressed cytoskeleton, [alpha]-actinin can retain conformation,...
- 6From: PLoS Computational Biology. (Vol. 5, Issue 5) Peer-ReviewedRelative to normal tissues, tumor microcirculation exhibits high structural and functional heterogeneity leading to hypoxic regions and impairing treatment efficacy. Here, computational simulations of blood vessel...
- 7From: PLoS Computational Biology. (Vol. 5, Issue 5) Peer-ReviewedOne of the most critical problems we face in the study of biological systems is building accurate statistical descriptions of them. This problem has been particularly challenging because biological systems typically...
- 8From: PLoS Computational Biology. (Vol. 5, Issue 5) Peer-ReviewedLarge-scale annotation efforts typically involve several experts who may disagree with each other. We propose an approach for modeling disagreements among experts that allows providing each annotation with a confidence...
- 9From: PLoS Computational Biology. (Vol. 5, Issue 5) Peer-ReviewedGreat strides have been made in understanding the evolutionary history of simian immunodeficiency virus (SIV) and the zoonoses that gave rise to HIV-1 and HIV-2. What remains unknown is how long these SIVs had been...
- 10From: PLoS Computational Biology. (Vol. 5, Issue 5) Peer-ReviewedStochastic resonance is said to be observed when increases in levels of unpredictable fluctuations--e.g., random noise--cause an increase in a metric of the quality of signal transmission or detection performance,...
- 11From: PLoS Computational Biology. (Vol. 5, Issue 5) Peer-ReviewedIntuitively, higher intelligence might be assumed to correspond to more efficient information transfer in the brain, but no direct evidence has been reported from the perspective of brain networks. In this study, we...
- 12From: PLoS Computational Biology. (Vol. 5, Issue 5) Peer-ReviewedCysteine (Cys) residues often play critical roles in proteins, for example, in the formation of structural disulfide bonds, metal binding, targeting proteins to the membranes, and various catalytic functions. However,...
- 13From: PLoS Computational Biology. (Vol. 5, Issue 5) Peer-ReviewedSystematic identification of protein-drug interaction networks is crucial to correlate complex modes of drug action to clinical indications. We introduce a novel computational strategy to identify protein-ligand binding...
- 14From: PLoS Computational Biology. (Vol. 5, Issue 5) Peer-ReviewedSensory processing is associated with gamma frequency oscillations (30-80 Hz) in sensory cortices. This raises the question whether gamma oscillations can be directly involved in the representation of time-varying...
- 15From: PLoS Computational Biology. (Vol. 5, Issue 5) Peer-ReviewedThe mature human brain is organized into a collection of specialized functional networks that flexibly interact to support various cognitive functions. Studies of development often attempt to identify the organizing...
- 16From: PLoS Computational Biology. (Vol. 5, Issue 5) Peer-ReviewedBackground The understanding of biological networks is a fundamental issue in computational biology. When analyzing topological properties of networks, one often tends to substitute the term "network" for "graph", or...
- 17From: PLoS Computational Biology. (Vol. 5, Issue 5) Peer-ReviewedThe development of Next Generation Sequencing technologies, capable of sequencing hundreds of millions of short reads (25-70 bp each) in a single run, is opening the door to population genomic studies of non-model...
- 18From: PLoS Computational Biology. (Vol. 5, Issue 5) Peer-ReviewedConformational ensembles are increasingly recognized as a useful representation to describe fundamental relationships between protein structure, dynamics and function. Here we present an ensemble of ubiquitin in...
- 19From: PLoS Computational Biology. (Vol. 5, Issue 5) Peer-ReviewedBiophysically detailed models of single cells are difficult to fit to real data. Recent advances in imaging techniques allow simultaneous access to various intracellular variables, and these data can be used to...
- 20From: PLoS Computational Biology. (Vol. 5, Issue 5) Peer-ReviewedThe BioLINK SIG meeting has been regularly held in association with the ISMB conference (Intelligent Systems for Molecular Biology--the annual conference of the International Society for Computational Biology) since...