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- 1From: Nature Reviews Endocrinology. (Vol. 5, Issue 4) Peer-ReviewedSymptoms of pediatric Gaucher disease type I (GD1)--an autosomal-recessive, lysosomal storage disease with a prevalence of 1 in 50,000 live births--substantially improve after long-term enzyme-replacement therapy. In 884...
- 2From: Nature Reviews Endocrinology. (Vol. 5, Issue 4) Peer-ReviewedAnemia is one of the world's most common preventable conditions, yet it is often overlooked, especially in people with diabetes mellitus. Diabetes-related chronic hyperglycemia can lead to a hypoxic environment in the...
- 3From: Nature Reviews Endocrinology. (Vol. 5, Issue 4) Peer-ReviewedAdolescent girls and young women with central adrenal insufficiency may benefit from hormone replacement with 25 mg dehydroepiandrosterone daily for 1 year. This treatment resulted in substantial progress in growth of...
- 4From: Nature Reviews Endocrinology. (Vol. 5, Issue 4) Peer-ReviewedDiabetes mellitus and an individual's genetic background are both known risk factors for cardiovascular disease. Nonetheless, researchers have been unsure whether a link exists between genetic risk factors and increased...
- 5From: Nature Reviews Endocrinology. (Vol. 5, Issue 4) Peer-ReviewedIn Gattaca, the science-fiction film released in 1997, a fictional world of genetic determinism is depicted, in which the entire genome of a newborn baby is sequenced and used to plot the child's life. This radical use...
- 6From: Nature Reviews Endocrinology. (Vol. 5, Issue 4) Peer-ReviewedA study that evaluated the natural history of bisphosphonate-related osteonecrosis of the jaw (ONJ)--an emergent problem for certain patients with cancer--found that reinitiation of bisphosphonate therapy and invasive...
- 7From: Nature Reviews Endocrinology. (Vol. 5, Issue 4) Peer-ReviewedPolymorphisms in estrogen receptor genes influence susceptibility to hot flashes during tamoxifen treatment in women with breast cancer. In a prospective, observational trial, 1-week hot-flash diaries were collected from...
- 8From: Nature Reviews Endocrinology. (Vol. 5, Issue 4) Peer-ReviewedAn increase in serum insulin levels rather than insulin action mediates the glucose-lowering effects of low-dose salicylates, according to a randomized, placebo-controlled trial. Beneficial effects of salicylates on...
- 9From: Nature Reviews Endocrinology. (Vol. 5, Issue 4) Peer-ReviewedType 1 diabetes mellitus (T1DM) is a chronic autoimmune disease with a strong inflammatory component. The latest studies indicate that innate immunity and inflammatory mediators have a much broader role in T1DM than...
- 10From: Nature Reviews Endocrinology. (Vol. 5, Issue 4) Peer-ReviewedA study suggests some of the drawbacks associated with the use of calcitonin as a marker of medullary thyroid carcinoma (MTC) might be overcome by measurement of procalcitonin. Algeciras-Schimnich et al. (Mayo Clinic,...
- 11From: Nature Reviews Endocrinology. (Vol. 5, Issue 4) Peer-ReviewedLyssenko et al. show that a variant of the melatonin receptor 1B gene is associated with increased risk of future type 2 diabetes mellitus by causing impairment of early insulin secretion. The pathogenic effects relate...
- 12From: Nature Reviews Endocrinology. (Vol. 5, Issue 4) Peer-ReviewedChanges in glycemic control after partial pancreatectomy are dependent on the part of the pancreas resected, according to a German research group. Menge and colleagues reported that removal of the pancreatic head...
- 13From: Nature Reviews Endocrinology. (Vol. 5, Issue 4) Peer-ReviewedInclusion of basal insulin glargine in multiple daily injection (MDI) regimens decreases glycemic variability in adolescents with type 1 diabetes mellitus (T1DM), according to US researchers. A key goal in the clinical...
- 14From: Nature Reviews Endocrinology. (Vol. 5, Issue 4) Peer-ReviewedOnly 1 in 10 overweight children and adolescents are diagnosed as having weight problems, despite the existence of clear diagnostic criteria. The diagnosis rate for overweight and obesity in this population increased...
- 15From: Nature Reviews Endocrinology. (Vol. 5, Issue 4) Peer-ReviewedKristrom et al. identify a novel mutation in the transcription factor gene LHX3 and describe the phenotype of six patients with this mutation. As well as combined pituitary hormone deficiency and restricted neck rotation...
- 16From: Nature Reviews Endocrinology. (Vol. 5, Issue 4) Peer-ReviewedThis US study found that pregnant women whose serum 25-hydroxyvitamin D levels were <37.5nmol/I at delivery were almost four times as likely to have a cesarean section as those with levels of ≥37.5 nmol/I. The authors...
- 17From: Nature Reviews Endocrinology. (Vol. 5, Issue 4) Peer-ReviewedA European trial of sequential treatment for osteoporosis shows a benefit of extending the use of the anabolic drug teriparatide to 2 years. Furthermore, this research demonstrates that anyprior treatment with...
- 18From: Nature Reviews Endocrinology. (Vol. 5, Issue 4) Peer-ReviewedTissue transplantation is a well-established tool for the treatment of degenerative and malignant disorders, yet its use in clinical practice is hampered by the need for human-leukocyte-antigen-compatible donors and a...
- 19From: Nature Reviews Endocrinology. (Vol. 5, Issue 4) Peer-ReviewedA pregnant woman's exposure to sunlight could be essential to the bone health of her child. Writing in the Journal of Clinical Endocrinology and Metabolism, Sayers and Tobias show that maternal exposure to sunlight...
- 20From: Nature Reviews Endocrinology. (Vol. 5, Issue 4) Peer-ReviewedNight-time levels of the gastric hormone ghrelin are markedly decreased in patients with chronic insomnia, confirms a study that included 14 men with the condition and 24 age-matched and weight-matched controls. Previous...