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- Search Terms:ISSN: 15537390AndISSN: 15537404AndVolume Number: 5AndIssue Number: 4AndStart Page: e1000459AndDate: 2009 Revise Search
- 1From: PLoS Genetics. (Vol. 5, Issue 4) Peer-ReviewedMobile elements comprise close to one half of the mass of the human genome. Only LINE-1 (L1), an autonomous non-Long Terminal Repeat (LTR) retrotransposition, and its non-autonomous partners-such as the...
- 2From: PLoS Genetics. (Vol. 5, Issue 4) Peer-ReviewedRecent genome-wide (GW) scans have identified several independent loci affecting human stature, but their contribution through the different skeletal components of height is still poorly understood. We carried out a...
- 3From: PLoS Genetics. (Vol. 5, Issue 4) Peer-ReviewedThe circadian clock is a molecular and cellular oscillator found in most mammalian tissues that regulates rhythmic physiology and behavior. Numerous investigations have addressed the contribution of circadian...
- 4From: PLoS Genetics. (Vol. 5, Issue 4) Peer-ReviewedIn humans, the absence or irreversible loss of hair cells, the sensory mechanoreceptors in the cochlea, accounts for a large majority of acquired and congenital hearing disorders. In the auditory and vestibular...
- 5From: PLoS Genetics. (Vol. 5, Issue 4) Peer-ReviewedMetabolic homeostasis in metazoans is regulated by endocrine control of insulin/IGF signaling (IIS) activity. Stress and inflammatory signaling pathways--such as Jun-N-terminal Kinase (JNK) signaling--repress IIS,...
- 6From: PLoS Genetics. (Vol. 5, Issue 4) Peer-ReviewedIt is generally accepted that neuroendocrine cells regulate dense core vesicle (DCV) biogenesis and cargo packaging in response to secretory demands, although the molecular mechanisms of this process are poorly...
- 7From: PLoS Genetics. (Vol. 5, Issue 4) Peer-ReviewedAntisense transcription is a pervasive phenomenon, but its source and functional significance is largely unknown. We took an expression-based approach to explore microRNA (miRNA)-related antisense transcription by...
- 8From: PLoS Genetics. (Vol. 5, Issue 4) Peer-ReviewedFragile X syndrome, a common form of inherited mental retardation, is caused by the loss of fragile X mental retardation protein (FMRP). We have previously demonstrated that dFmr1, the Drosophila ortholog of the fragile...
- 9From: PLoS Genetics. (Vol. 5, Issue 4) Peer-ReviewedInsulin/IGF-1 signaling (IIS) regulates development and metabolism, and modulates aging, of Caenorhabditis elegans. In nematodes, as in mammals, IIS is understood to operate through a kinase-phosphorylation cascade that...
- 10From: PLoS Genetics. (Vol. 5, Issue 4) Peer-ReviewedWhen mitochondrial respiration or ubiquinone production is inhibited in Caenorhabditis elegans, behavioral rates are slowed and lifespan is extended. Here, we show that these perturbations increase the expression of...
- 11From: PLoS Genetics. (Vol. 5, Issue 4) Peer-ReviewedThe transition from hunting and gathering to farming involved a major cultural innovation that has spread rapidly over most of the globe in the last ten millennia. In sub-Saharan Africa, hunter- gatherers have begun to...
- 12From: PLoS Genetics. (Vol. 5, Issue 4) Peer-ReviewedLong interspersed elements (LINES) are transposable elements that proliferate within eukaryotic genomes, having a large impact on eukaryotic genome evolution. LINES mobilize via a process called retrotransposition....
- 13From: PLoS Genetics. (Vol. 5, Issue 4) Peer-ReviewedThe ongoing release of numerous genome sequences constitutes a scientific landmark that has transformed our way of thinking about the organization of living matter. The complete list of annotated genes that is finally...
- 14From: PLoS Genetics. (Vol. 5, Issue 4) Peer-ReviewedCharacterizing how genomic sequence interacts with trans-acting regulatory factors to implement a program of gene expression in eukaryotic organisms is critical to understanding genome function. One means by which...
- 15From: PLoS Genetics. (Vol. 5, Issue 4) Peer-ReviewedGenomic mapping of DNA replication origins (ORIs) in mammals provides a powerful means for understanding the regulatory complexity of our genome. Here we combine a genome-wide approach to identify preferential sites of...
- 16From: PLoS Genetics. (Vol. 5, Issue 4) Peer-ReviewedThe majority of the genome in animals and plants is transcribed in a developmentally regulated manner to produce large numbers of non-protein-coding RNAs (ncRNAs), whose incidence increases with developmental...
- 17From: PLoS Genetics. (Vol. 5, Issue 4) Peer-ReviewedMetazoan development requires complex mechanisms to generate cells with diverse function. Alternative splicing of premRNA not only expands proteomic diversity but also provides a means to regulate tissue-specific...
- 18From: PLoS Genetics. (Vol. 5, Issue 4) Peer-ReviewedModern computational methods are revealing putative transcription-factor (TF) binding sites at an extraordinary rate. However, the major challenge in studying transcriptional networks is to map these regulatory element...
- 19From: PLoS Genetics. (Vol. 5, Issue 4) Peer-ReviewedCLK-2/TEL2 is essential for viability from yeasts to vertebrates, but its essential functions remain ill defined. CLK-2/TEL2 was initially implicated in telomere length regulation in budding yeast, but work in...
- 20From: PLoS Genetics. (Vol. 5, Issue 4) Peer-ReviewedThe sense of taste is of critical importance to animal survival. Although studies of taste signal transduction mechanisms have provided detailed information regarding taste receptor calcium signaling molecules (TRCSMs,...