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- Search Terms:ISSN: 1553734XAndISSN: 15537358AndVolume Number: 5AndIssue Number: 4AndStart Page: e1000353AndDate: 2009 Revise Search
- 1From: PLoS Computational Biology. (Vol. 5, Issue 4) Peer-ReviewedThe late Lindley J. Stiles famously made himself an advocate for teaching during his professorship at the University of Colorado: "If a better world is your aim, all must agree: The best should teach"...
- 2From: PLoS Computational Biology. (Vol. 5, Issue 4) Peer-ReviewedOrientation selectivity is the most striking feature of simple cell coding in V1 that has been shown to emerge from the reduction of higher-order correlations in natural images in a large variety of statistical image...
- 3From: PLoS Computational Biology. (Vol. 5, Issue 4) Peer-ReviewedRecent studies of cellular networks have revealed modular organizations of genes and proteins. For example, in interactome networks, a module refers to a group of interacting proteins that form molecular complexes...
- 4From: PLoS Computational Biology. (Vol. 5, Issue 4) Peer-ReviewedWhen modeling cell signaling networks, a balance must be struck between mechanistic detail and ease of interpretation. In this paper we apply a fuzzy logic framework to the analysis of a large, systematic dataset...
- 5From: PLoS Computational Biology. (Vol. 5, Issue 4) Peer-ReviewedScientific and technological advances that enable the tuning of integrated regulatory components to match network and system requirements are critical to reliably control the function of biological systems. RNA provides...
- 6From: PLoS Computational Biology. (Vol. 5, Issue 4) Peer-ReviewedDNA-protein interactions are involved in many essential biological activities. Because there is no simple mapping code between DNA base pairs and protein amino acids, the prediction of DNA-protein interactions is a...
- 7From: PLoS Computational Biology. (Vol. 5, Issue 4) Peer-ReviewedNuclear genes encode most mitochondrial proteins, and their mutations cause diverse and debilitating clinical disorders. To date, 1,200 of these mitochondrial genes have been recorded, while no standardized catalog...
- 8From: PLoS Computational Biology. (Vol. 5, Issue 4) Peer-ReviewedAvian influenza virus (AIV) persists in North American wild waterfowl, exhibiting major outbreaks every 2-4 years. Attempts to explain the patterns of periodicity and persistence using simple direct transmission models...
- 9From: PLoS Computational Biology. (Vol. 5, Issue 4) Peer-ReviewedBiological systems often display modularity, in the sense that they can be decomposed into nearly independent subsystems. Recent studies have suggested that modular structure can spontaneously emerge if goals...
- 10From: PLoS Computational Biology. (Vol. 5, Issue 4) Peer-ReviewedSymbiosis has been among the most important evolutionary steps to generate biological complexity. The establishment of symbiosis required an intimate metabolic link between biological systems with different complexity...
- 11From: PLoS Computational Biology. (Vol. 5, Issue 4) Peer-ReviewedRyanodine receptors (RyRs) are ion channels that regulate muscle contraction by releasing calcium ions from intracellular stores into the cytoplasm. Mutations in skeletal muscle RyR (RyR1) give rise to congenital...
- 12From: PLoS Computational Biology. (Vol. 5, Issue 4) Peer-ReviewedThe use of networks to integrate different genetic, proteomic, and metabolic datasets has been proposed as a viable path toward elucidating the origins of specific diseases. Here we introduce a new phenotypic database...
- 13From: PLoS Computational Biology. (Vol. 5, Issue 4) Peer-ReviewedThe asexual reproduction cycle of Plasmodium falciparum, the parasite responsible for severe malaria, occurs within red blood cells. A merozoite invades a red cell in the circulation, develops and multiplies, and after...
- 14From: PLoS Computational Biology. (Vol. 5, Issue 4) Peer-ReviewedScientific innovation depends on finding, integrating, and re-using the products of previous research. Here we explore how recent developments in Web technology, particularly those related to the publication of data and...
- 15From: PLoS Computational Biology. (Vol. 5, Issue 4) Peer-ReviewedMost cell surface receptors for growth factors and cytokines dimerize in order to mediate signal transduction. For many such receptors, the Janus kinase (Jak) family of non-receptor protein tyrosine kinases are...
- 16From: PLoS Computational Biology. (Vol. 5, Issue 4) Peer-ReviewedSynchronized oscillation is very commonly observed in many neuronal systems and might play an important role in the response properties of the system. We have studied how the spontaneous oscillatory activity affects the...
- 17From: PLoS Computational Biology. (Vol. 5, Issue 4) Peer-ReviewedSequence data arising from an increasing number of partial and complete genome projects is revealing the presence of the polyketide synthase (PKS) family of genes not only in microbes and fungi but also in plants and...
- 18From: PLoS Computational Biology. (Vol. 5, Issue 4) Peer-ReviewedHow can we optimize the use of drugs against parasites to limit the evolution of drug resistance? This question has been addressed by many theoretical studies focusing either on the mixing of various treatments, or...
- 19From: PLoS Computational Biology. (Vol. 5, Issue 4) Peer-ReviewedWhat is the underlying mechanism behind the fat-tailed statistics observed for species abundance distributions? The two main hypotheses in the field are the adaptive (niche) theories, where species abundance reflects...
- 20From: PLoS Computational Biology. (Vol. 5, Issue 4) Peer-ReviewedAn increasing number of cis-regulatory RNA elements have been found to regulate gene expression post-transcriptionally in various biological processes in bacterial systems. Effective computational tools for large-scale...