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- Search Terms:ISSN: 15491277AndISSN: 15491676AndVolume Number: 5AndIssue Number: 4AndStart Page: e66AndDate: 2008 Revise Search
- 1From: PLoS Medicine. (Vol. 5, Issue 4) Peer-ReviewedThis is the first in a series of articles on confirming research during complex humanitarian emergencies. The United Nations (UN) defines a complex humanitarian emergency (CHE) as "a humanitarian crisis in a country,...
- 2From: PLoS Medicine. (Vol. 5, Issue 4) Peer-ReviewedThis is the second in a series of articles arising from the 2007 Global HIV Vaccine Enterprise workshops. The first was published in December 2007 (PLoSMed 4(12): e348. doi:10.1371/ journal.pmed. 0040348). The...
- 3From: PLoS Medicine. (Vol. 5, Issue 4) Peer-ReviewedBackground Pancreatic ductal adenocarcinoma (PDAC) carries an extremely poor prognosis, typically presenting with metastasis at the time of diagnosis and exhibiting profound resistance to existing therapies. The...
- 4From: PLoS Medicine. (Vol. 5, Issue 4) Peer-ReviewedPneumonia is the single commonest cause of death Pin children under five years old, accounting for 2 million out of 10 million childhood deaths worldwide [1]. Severe pneumonia is an important diagnostic syndrome within...
- 5From: PLoS Medicine. (Vol. 5, Issue 4) Peer-ReviewedBackground In clinical trials the selection of appropriate outcomes is crucial to the assessment of whether one intervention is better than another. Selection of inappropriate outcomes can compromise the utility of a...
- 6From: PLoS Medicine. (Vol. 5, Issue 4) Peer-ReviewedFor many years it was widely believed that known vascular risk factors could explain only about half of all cardiovascular disease [1], leaving much to be discovered about other causes of stroke and heart attack. There...
- 7From: PLoS Medicine. (Vol. 5, Issue 4) Peer-ReviewedWhether decisions about the health care of children are made by parents, carers, health practitioners, or children themselves, ideally these decisions will be informed by the results of systematic reviews of previous...
- 8From: PLoS Medicine. (Vol. 5, Issue 4) Peer-ReviewedBackground The relevance to coronary heart disease (CHD) of cytokines that govern inflammatory cascades, such as interleukin-6 (IL-6), may be underestimated because such mediators are short acting and prone to...
- 9From: PLoS Medicine. (Vol. 5, Issue 4) Peer-ReviewedBackground Childhood acute lymphoblastic leukemia (ALL) is the most common cancer in children, and can now be cured in approximately 80% of patients. Nevertheless, drug resistance is the major cause of treatment...
- 10From: PLoS Medicine. (Vol. 5, Issue 4) Peer-ReviewedBackground There are no published data on national lifetime prevalence and treatment of mental disorders in the Arab region. Furthermore, the effect of war on first onset of disorders has not been addressed...
- 11From: PLoS Medicine. (Vol. 5, Issue 4) Peer-ReviewedBackground Idiopathic pulmonary fibrosis (IPF) is a chronic progressive fibrotic lung disease associated with substantial morbidity and mortality. The objective of this study was to determine whether there is a...
- 12From: PLoS Medicine. (Vol. 5, Issue 4) Peer-Reviewed
Cytological and transcript analyses reveal fat and lazy persister-like bacilli in tuberculous sputum
Background Tuberculous sputum provides a sample of bacilli that must be eliminated by chemotherapy and that may go on to transmit infection. A preliminary observation that Mycobacterium tuberculosis cells contain... - 13From: PLoS Medicine. (Vol. 5, Issue 4) Peer-ReviewedBackground Counties are the smallest unit for which mortality data are routinely available, allowing consistent and comparable long-term analysis of trends in health disparities. Average life expectancy has steadily...
- 14From: PLoS Medicine. (Vol. 5, Issue 4) Peer-ReviewedWorldwide, Haemophilus influenzae type b (Hib) causes at least 3 million cases of severe disease each year. Approximately 400,000 children die annually due to pneumonia or meningitis caused by Hib [1]. Severe...
- 15From: PLoS Medicine. (Vol. 5, Issue 4) Peer-ReviewedPLoS Medicine aims to publish important studies from all medical disciplines that provide a substantial advance either in clinical practice, public heath policy, or basic pathophysiology. Though this is a lofty aim it...
- 16From: PLoS Medicine. (Vol. 5, Issue 4) Peer-ReviewedBackground There have been increasing concerns regarding the safety and efficacy of neuroleptics in people with dementia, but there are very few long-term trials to inform clinical practice. The aim of this study was...
- 17From: PLoS Medicine. (Vol. 5, Issue 4) Peer-ReviewedWhile large-scale national psychiatric epidemiologic studies have been conducted in Western industrialized nations [1-3], studies in the Arab world have generally been limited to smaller populations [4-6]. In addition,...
- 18From: PLoS Medicine. (Vol. 5, Issue 4) Peer-ReviewedBackground HIV surveillance of generalised epidemics in Africa primarily relies on prevalence at antenatal clinics, but estimates of incidence in the general population would be more useful. Repeated cross-sectional...
- 19From: PLoS Medicine. (Vol. 5, Issue 4) Peer-ReviewedIdiopathic pulmonary fibrosis (IPF) is a disease of unknown aetiology and uncertain pathogenesis, and there are no effective therapies. IPF, also known as usual interstitial pneumonia and cryptogenic fibrosing...
- 20From: PLoS Medicine. (Vol. 5, Issue 4) Peer-ReviewedThe Chilean health system has been studied extensively [1]. TITS current form is the result of a major reform undertaken by the Pinochet government following the coup d'etatin 1973. Pinochet's reform established...