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- 1From: Stem Cell Research & Therapy. (Vol. 5, Issue 4) Peer-ReviewedMounting evidence indicates that the regenerative effect of mesenchymal stem cells in skeletal muscle is related to the secretion of factors that stimulate resident myogenic cells. However, the environmental cues that...
- 2From: Stem Cell Research & Therapy. (Vol. 5, Issue 4) Peer-ReviewedAuthor(s): Alfonso Eirin1 and Lilach O Lerman1 Chronic kidney disease (CKD) is a prevalent condition (8 to 16%) associated with all-cause and cardiovascular mortality [1]. Importantly, CKD can progress towards...
- 3From: Stem Cell Research & Therapy. (Vol. 5, Issue 4) Peer-ReviewedMesenchymal stem cells (MSCs) are an adult stromal cell population possessing potent differentiation capacity and a potential for use across major histocompatibility complex barriers. Although allogeneic MSCs have...
- 4From: Stem Cell Research & Therapy. (Vol. 5, Issue 4) Peer-ReviewedIntroduction Autologous mesenchymal stem cells (MSCs) are an attractive concept in regenerative medicine, but their mechanism of action remains poorly defined. No immune response is reported after in vivo injection...
- 5From: Stem Cell Research & Therapy. (Vol. 5, Issue 4) Peer-ReviewedIntroduction Our previous works demonstrated that systemic orbital fat-derived stem cell (OFSC) transplantation was effective in ameliorating lipopolysaccharide (LPS)-induced extensive acute lung injury (ALI) in vivo...
- 6From: Stem Cell Research & Therapy. (Vol. 5, Issue 4) Peer-ReviewedAuthor(s): Janina Frisch1 , Jagadeesh Kumar Venkatesan1 , Ana Rey-Rico1 , Gertrud Schmitt1 , Henning Madry1,2 and Magali Cucchiarini1 Injured adult articular cartilage, the tissue that allows for smooth gliding and...
- 7From: Stem Cell Research & Therapy. (Vol. 5, Issue 4) Peer-ReviewedAuthor(s): Li Xing1,2 , Rui Cui1 , Lei Peng1 , Jing Ma1 , Xiao Chen1 , Ru-Juan Xie2 and Bing Li1 Acute kidney injury (AKI) is one of the most important causes of mortality and morbidity worldwide. In clinical...
- 8From: Stem Cell Research & Therapy. (Vol. 5, Issue 4) Peer-ReviewedMotor neurons are cells located in specific areas of the central nervous system, such as brain cortex (upper motor neurons), brain stem, and spinal cord (lower motor neurons), which maintain control over voluntary...
- 9From: Stem Cell Research & Therapy. (Vol. 5, Issue 4) Peer-ReviewedIntroduction Osteoporosis is a disease characterized by low bone mineral density (BMD) and increased risk of fractures. Studies have demonstrated the use of phytoestrogens, or plant-derived estrogens, such as...
- 10From: Stem Cell Research & Therapy. (Vol. 5, Issue 4) Peer-ReviewedMicroRNAs regulate target gene expression post-transcriptionally in a myriad of cell types and play critical roles in diverse physiological and pathological processes, including cardiomyocyte development,...
- 11From: Stem Cell Research & Therapy. (Vol. 5, Issue 4) Peer-ReviewedThe loss of neurons and degeneration of axons after spinal cord injury result in the loss of sensory and motor functions. A bridging biomaterial construct that allows the axons to grow through has been investigated for...
- 12From: Stem Cell Research & Therapy. (Vol. 5, Issue 4) Peer-ReviewedIntroduction Aromatic (ar-) turmerone is a major bioactive compound of the herb Curcuma longa. It has been suggested that ar-turmerone inhibits microglia activation, a property that may be useful in treating...
- 13From: Stem Cell Research & Therapy. (Vol. 5, Issue 4) Peer-ReviewedAuthor(s): Daniela Nascimento Silva1,2 , Bruno Solano de Freitas Souza1,2 , Carine Machado Azevedo1,2 , Juliana Fraga Vasconcelos1,2 , Rejane Hughes Carvalho1 , Milena Botelho Pereira Soares1,2 and Ricardo Ribeiro dos...
- 14From: Stem Cell Research & Therapy. (Vol. 5, Issue 4) Peer-ReviewedAuthor(s): Claire Masterson1 and Daniel O'Toole2 The mesenchymal stromal cell (MSC) as a proposed treatment for acute respiratory distress syndrome (ARDS) appears to be rapidly approaching the moment of truth for any...
- 15From: Stem Cell Research & Therapy. (Vol. 5, Issue 4) Peer-ReviewedIntroduction Mesenchymal stromal/stem cells (MSCs) for clinical use have largely been isolated from the bone marrow, although isolation of these cells from many different adult and fetal tissues has been reported as...
- 16From: Stem Cell Research & Therapy. (Vol. 5, Issue 4) Peer-ReviewedAuthor(s): Cheryl E Dunlop1 , Evelyn E Telfer2 and Richard A Anderson1 Germline stem cells (GSCs) are a unique cell population committed to producing gametes for the propagation of the species. The concept of a GSC...
- 17From: Stem Cell Research & Therapy. (Vol. 5, Issue 4) Peer-ReviewedAuthor(s): Aida Llucià-Valldeperas1 , Benjamin Sanchez2 , Carolina Soler-Botija1 , Carolina Gálvez-Montón1 , Santiago Roura1 , Cristina Prat-Vidal1 , Isaac Perea-Gil1 , Javier Rosell-Ferrer3 , Ramon Bragos3 and Antoni...
- 18From: Stem Cell Research & Therapy. (Vol. 5, Issue 4) Peer-ReviewedAuthor(s): Xiaoming Wang1 , Hui Zhang2 , Liangming Nie1 , Linhai Xu1 , Min Chen3 and Zhaoping Ding4 Adipose tissue is now recognized as an abundant, easily accessible source for obtaining regenerative...
- 19From: Stem Cell Research & Therapy. (Vol. 5, Issue 4) Peer-ReviewedIntroduction Mesenchymal stromal cells (MSC) are an integral cellular component of the tumor microenvironment. Nevertheless, very little is known about MSC originating from human malignant tissue and modulation of...
- 20From: Stem Cell Research & Therapy. (Vol. 5, Issue 4) Peer-ReviewedAuthor(s): Michael J Mienaltowski1,2,3 , Sheila M Adams1 and David E Birk1,2 Native repair of tendon following an injury such as a rupture or a tear is achieved through intrinsic and extrinsic mechanisms. When an...