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- Search Terms:ISSN: 17312302AndISSN: 18974287AndVolume Number: 5AndIssue Number: 3AndStart Page: 164AndDate: 2007 Revise Search
- 1From: Hereditary Cancer in Clinical Practice. (Vol. 5) Peer-ReviewedMen who carry mutations in BRCA1 or BRCA2 are at increased risk for prostate cancer. However the efficacy of prostate screening in this setting is uncertain and limited data exists on the uptake of prostate screening by...
- 2From: Hereditary Cancer in Clinical Practice. (Vol. 5) Peer-ReviewedThe molecular diagnostics of genetically conditioned disorders is based on the identification of the mutations in the predisposing genes. Hereditary cancer disorders of the gastrointestinal tracts are caused by...
- 3From: Hereditary Cancer in Clinical Practice. (Vol. 5) Peer-ReviewedModifying factors might theoretically determine whether a BRCA1 mutation carrier contracts breast or ovarian cancer. If so, one would expect concordance for breast or ovarian cancer in affected sibships. We identified...
- 4From: Hereditary Cancer in Clinical Practice. (Vol. 5) Peer-ReviewedBRCA1 and BRCA2 germ-line mutations occur in a significant number of unselected ovarian cancer (OC) patients, thus making a noticeable contribution to OC morbidity. It is of interest whether CHEK2, which is frequently...
- 5From: Hereditary Cancer in Clinical Practice. (Vol. 5) Peer-ReviewedEpidemiologic research conducted over the last two decades has led us to believe that inherited factors play an important role in the aetiology of prostate cancer, but the genes which underlie the inherited...
- 6From: Hereditary Cancer in Clinical Practice. (Vol. 5) Peer-ReviewedAuthors: (corresponding author) Amsterdam-Defined Asian HNPCC Patients: Data From the Singapore Polyposis Registry Poh-Koon Koh , Min-Hoe Chew, Carol Loi, Choong-Leong Tang, Kong-Weng Eu Singapore Polyposis...
- 7From: Hereditary Cancer in Clinical Practice. (Vol. 5) Peer-ReviewedPolymorphisms in the ARLTS1 gene, a member of the Ras super-family, have been associated with susceptibility in different cancer types. The involvement of the gene in apoptotic signalling motivated us to study the role...
- 8From: Hereditary Cancer in Clinical Practice. (Vol. 5) Peer-ReviewedBased on epidemiological data we can assume that at least some malignant melanoma (MM) and breast cancer cases can be caused by the same genetic factors. CDKN2A, which encodes the p16 protein, a cyclin-dependent kinase...
- 9From: Hereditary Cancer in Clinical Practice. (Vol. 5) Peer-ReviewedAuthors: (corresponding author) Clinical phenotype of individuals with germline mutations in the PMS2 gene Leigha Senter, Mark Clendenning, Heather Hampel, Kaisa Sotamaa, Albert de la Chapelle Human Cancer...
- 10From: Hereditary Cancer in Clinical Practice. (Vol. 5) Peer-ReviewedThe specific characteristics of genetic data lead to ethical-legal conflicts in the framework of genetic diagnosis. Several international organisations, including UNESCO and the Council of Europe, have enacted rules...
- 11From: Hereditary Cancer in Clinical Practice. (Vol. 5) Peer-ReviewedBackground This study examined: (1) levels of cancer-specific distress more than one year after genetic counselling for hereditary nonpolyposis colorectal cancer (HNPCC); (2) associations between sociodemographic,...
- 12From: Hereditary Cancer in Clinical Practice. (Vol. 5) Peer-ReviewedHereditary diffuse gastric cancer (HDGC) is the only known predisposition syndrome dominated by carcinoma of the stomach and with a recognised genetic cause. Germline mutations in the E-cadherin gene (CDH1) co-segregate...
- 13From: Hereditary Cancer in Clinical Practice. (Vol. 5) Peer-ReviewedObjectives To conduct a pilot population-based study within a general practice catchment area to determine whether the incidence of breast cancer was increased in the Ashkenazi population. Design...
- 14From: Hereditary Cancer in Clinical Practice. (Vol. 5) Peer-ReviewedMultiple myeloma (MM) is a relatively rare haematological malignancy seen in older persons. It has an unknown aetiology and usually occurs incidentally within a family. However, several families have been reported with...
- 15From: Hereditary Cancer in Clinical Practice. (Vol. 5) Peer-ReviewedAuthors: R Doherty [1]; J Lubinski [2]; E Manguoglu [3]; G Luleci [3]; M Christie [4]; P Craven [4]; E Bancroft [5]; A Mitra [1]; S Morgan [1]; R Eeles (corresponding author) [1,4] Introduction IMPACT...
- 16From: Hereditary Cancer in Clinical Practice. (Vol. 5) Peer-ReviewedAuthors: (corresponding author) Pavel Elsakov, Vilnius University, Institute of Oncology, Lithuania BRCA1 -associated cancers differ from non-hereditary cancers for many factors, including somatic mutation. It can...
- 17From: Hereditary Cancer in Clinical Practice. (Vol. 5) Peer-ReviewedAuthors: (corresponding author) In the last issue of our journal, in the article BRCA1 4153delA founder mutation in Russian ovarian cancer patients written by Prof. Evgeny N. Imyanitov, the following errata apply....
- 18From: Hereditary Cancer in Clinical Practice. (Vol. 5) Peer-ReviewedThe correction of exogenous and endogenous environmental insult to DNA involves a series of DNA repair mechanisms that reduce the likelihood of mutation accumulation and hence an increased probability of tumour...
- 19From: Hereditary Cancer in Clinical Practice. (Vol. 5) Peer-ReviewedThis work consists of six parts based on seven manuscripts dealing with some aspects of genetic counselling for BRCA1 mutation carriers. It was demonstrated that the risk of breast and ovarian cancer in first-degree...
- 20From: Hereditary Cancer in Clinical Practice. (Vol. 5) Peer-ReviewedGene expression profiling is a powerful method by which alterations in gene expression can be interrogated in a single experiment. The disease familial adenomatous polyposis (FAP) is associated with germline mutations...