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- 1From: PLoS Genetics. (Vol. 5, Issue 3) Peer-ReviewedThis research investigates the influence of demographic factors on human genetic sub-structure. In our discovery cohort, we show significant demographic trends for decreasing autozygosity associated with population...
- 2From: PLoS Genetics. (Vol. 5, Issue 3) Peer-ReviewedThe Escherichia coli mazEF module is one of the most thoroughly studied toxin-antitoxin systems. mozF encodes a stable toxin, MazF, and mazE encodes a labile antitoxin, MazE, which prevents the lethal effect of MazF....
- 3From: PLoS Genetics. (Vol. 5, Issue 3) Peer-ReviewedGenetic background exerts a strong modulatory effect on the toxicity of aggregation-prone proteins in conformational diseases. In addition to influencing the misfolding and aggregation behavior of the mutant proteins,...
- 4From: PLoS Genetics. (Vol. 5, Issue 3) Peer-ReviewedIn recent years, bacterial geneticists and microbiologists have begun moving away from the view that the clonal cell populations they study in the lab are homogeneous lots of identical, autonomous individuals and toward...
- 5From: PLoS Genetics. (Vol. 5, Issue 3) Peer-ReviewedPopulations of Human Immunodeficiency Virus type 1 (HIV-1) undergo a surprisingly large amount of genetic drift in infected patients despite very large population sizes, which are predicted to be mostly deterministic....
- 6From: PLoS Genetics. (Vol. 5, Issue 3) Peer-ReviewedPrecise coordination between stamen and pistil development is essential to make a fertile flower. Mutations impairing stamen filament elongation, pollen maturation, or anther dehiscence will cause male sterility....
- 7From: PLoS Genetics. (Vol. 5, Issue 3) Peer-ReviewedDifferential DNA methylation is an essential epigenetic signal for gene regulation, development, and disease processes. We mapped DNA methylation patterns of 190 gene promoter regions on chromosome 21 using bisulfite...
- 8From: PLoS Genetics. (Vol. 5, Issue 3) Peer-ReviewedLaribacter hongkongensis is a newly discovered Gram-negative bacillus of the Neisseriaceae family associated with freshwater fish-borne gastroenteritis and traveler's diarrhea. The complete genome sequence of L....
- 9From: PLoS Genetics. (Vol. 5, Issue 3) Peer-ReviewedSingle amino acid repeats are prevalent in eukaryote organisms, although the role of many such sequences is still poorly understood. We have performed a comprehensive analysis of the proteins containing homopolymeric...
- 10From: PLoS Genetics. (Vol. 5, Issue 3) Peer-ReviewedA common yet poorly understood evolutionary transition among flowering plants is a switch from outbreeding to an inbreeding mode of mating. The model plant Arabidopsis thaliana evolved to an inbreeding state through the...
- 11From: PLoS Genetics. (Vol. 5, Issue 3) Peer-ReviewedMitochondria are central to many cellular processes including respiration, ion homeostasis, and apoptosis. Using computational predictions combined with traditional quantitative experiments, we have identified 100...
- 12From: PLoS Genetics. (Vol. 5, Issue 3) Peer-ReviewedOne of the earliest morphogenetic processes in the development of many animals is epiboly. In the zebrafish, epiboly ensues when the animally localized blastoderm cells spread, thin over, and enclose the vegetally...
- 13From: PLoS Genetics. (Vol. 5, Issue 3) Peer-ReviewedHomologous recombination is an important mechanism for the repair of DNA damage in mitotically dividing cells. Mitotic crossovers between homologues with heterozygous alleles can produce two homozygous daughter cells...
- 14From: PLoS Genetics. (Vol. 5, Issue 3) Peer-ReviewedBeckwith-Wiedemann syndrome (BWS) is a fetal overgrowth and human imprinting disorder resulting from the deregulation of a number of genes, including IGF2 and CDKNIC, in the imprinted gene cluster on chromosome 11p15.5....
- 15From: PLoS Genetics. (Vol. 5, Issue 3) Peer-ReviewedPathogenicity differences among laboratory isolates of the dominant clonal North American and European lineages of Toxoplasma gondii are largely controlled by polymorphisms and expression differences in rhoptry secretory...
- 16From: PLoS Genetics. (Vol. 5, Issue 3) Peer-ReviewedNumerous genetic association studies have implicated the KIAA0319 gene on human chromosome 6p22 in dyslexia susceptibility. The causative variant(s) remains unknown but may modulate gene expression, given that (1) a...
- 17From: PLoS Genetics. (Vol. 5, Issue 3) Peer-ReviewedThe evolutionary history of biological pathways is of general interest, especially in this post-genomic era, because it may provide clues for understanding how complex systems encoded on genomes have been organized. To...
- 18From: PLoS Genetics. (Vol. 5, Issue 3) Peer-ReviewedTo better understand adaptation to harsh conditions encountered in hot arid deserts, we report the first complete genome sequence and proteome analysis of a bacterium, Deinococcus deserti VCD115, isolated from Sahara...
- 19From: PLoS Genetics. (Vol. 5, Issue 3) Peer-ReviewedGlucose is the preferred carbon and energy source in prokaryotes, unicellular eukaryotes, and metazoans. However, excess of glucose has been associated with several diseases, including diabetes and the less understood...
- 20From: PLoS Genetics. (Vol. 5, Issue 3) Peer-ReviewedThere is considerable variability in the susceptibility of smokers to develop chronic obstructive pulmonary disease (COPD). The only known genetic risk factor is severe deficiency of [α.sub.1]-antitrypsin, which is...