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- Search Terms:ISSN: 15537366AndISSN: 15537374AndVolume Number: 5AndIssue Number: 3AndStart Page: e1000352AndDate: 2009 Revise Search
- 1From: PLoS Pathogens. (Vol. 5, Issue 3) Peer-Reviewed
Cholesterol-dependent Anaplasma phagocytophilum exploits the low-density lipoprotein uptake pathway.
In eukaryotes, intracellular cholesterol homeostasis and trafficking are tightly regulated. Certain bacteria, such as Anaplasma phagocytophilum, also require cholesterol; it is unknown, however, how this... - 2From: PLoS Pathogens. (Vol. 5, Issue 3) Peer-ReviewedWolbachia is a bacteria endosymbiont that rapidly infects insect populations through a mechanism known as cytoplasmic incompatibility (Cq. In CI, crosses between Wolbachia-infected males and uninfected females produce...
- 3From: PLoS Pathogens. (Vol. 5, Issue 3) Peer-ReviewedIn addition to the previously characterized viruses BK and JC, three new human polyomaviruses (Pys) have been recently identified: KIV, WUV, and Merkel Cell Py (MCV). Using an ELISA employing recombinant VP1 capsid...
- 4From: PLoS Pathogens. (Vol. 5, Issue 3) Peer-ReviewedHelicobacter pylori are gram-negative bacteria notable for their high level of genetic diversity and plasticity, features that may play a key role in the organism's ability to colonize the human stomach. Homeologous...
- 5From: PLoS Pathogens. (Vol. 5, Issue 3) Peer-ReviewedPlus-strand RNA viruses contain RNA elements within their genomes that mediate a variety of fundamental viral processes. The traditional view of these elements is that of local RNA structures. This perspective, however,...
- 6From: PLoS Pathogens. (Vol. 5, Issue 3) Peer-ReviewedOpen reading frame (ORF) 45 of Kaposi's sarcoma-associated herpesvirus (KSHV) is a tegument protein. A genetic analysis with a null mutant suggested a possible role for this protein in the events leading to viral egress....
- 7From: PLoS Pathogens. (Vol. 5, Issue 3) Peer-ReviewedThe continued evolution of bacterial pathogens has major implications for both human and animal disease, but the exchange of genetic material between host-restricted pathogens is rarely considered. Streptococcus equi...
- 8From: PLoS Pathogens. (Vol. 5, Issue 3) Peer-ReviewedThe human cytidine deaminase APOBEC3G (A3G) is a potent inhibitor of retroviruses and transposable elements and is able to deaminate cytidines to uridines in single-stranded DNA replication intermediates. A3G contains...
- 9From: PLoS Pathogens. (Vol. 5, Issue 3) Peer-ReviewedMycobacterium tuberculosis, the etiological agent of TB, possesses a cholesterol catabolic pathway implicated in pathogenesis. This pathway includes an iron-dependent extradiol dioxygenase, HsaC, that cleaves catechols....
- 10From: PLoS Pathogens. (Vol. 5, Issue 3) Peer-ReviewedProduction of type I interferons (IFN-I, mainly IFNα and IFNβ) is a hallmark of innate immune responses to all classes of pathogens. When viral infection spreads to lymphoid organs, the majority of systemic IFN-I is...
- 11From: PLoS Pathogens. (Vol. 5, Issue 3) Peer-ReviewedTwo factors contribute to Burkitt lymphoma (BL) pathogenesis, a chromosomal translocation leading to c-myc oncogene deregulation and infection with Epstein-Barr virus (EBV). Although the virus has B cell...
- 12From: PLoS Pathogens. (Vol. 5, Issue 3) Peer-ReviewedRetroviruses and retrotransposons are vulnerable to a suicidal pathway known as autointegration, which occurs when the 3'-ends of the reverse transcript are activated by integrase and then attack sites within the viral...
- 13From: PLoS Pathogens. (Vol. 5, Issue 3) Peer-ReviewedBorrelia burgdorferi, the bacterial pathogen of Lyme borreliosis, differentially expresses select genes in vivo, likely contributing to microbial persistence and disease. Expression analysis of spirochete genes encoding...
- 14From: PLoS Pathogens. (Vol. 5, Issue 3) Peer-ReviewedThe hemagglutinin (HA) of influenza A viruses has been classified into sixteen distinct subtypes (H1-H16) to date. The HA subtypes of influenza A viruses are principally defined as serotypes determined by neutralization...
- 15From: PLoS Pathogens. (Vol. 5, Issue 3) Peer-ReviewedImmunoglobulin A (IgA) secretion by plasma cells in the immune system is critical for protecting the host from environmental and microbial infections. However, the molecular mechanisms underlying the generation of...
- 16From: PLoS Pathogens. (Vol. 5, Issue 3) Peer-ReviewedThe mechanism controlling the exit from herpes simplex virus latency (HSV) is of central importance to recurrent disease and transmission of infection, yet interactions between host and viral functions that govern this...
- 17From: PLoS Pathogens. (Vol. 5, Issue 3) Peer-ReviewedBcl-2 family proteins including the pro-apoptotic BH3-only proteins are central regulators of apoptotic cell death. Here we show by a focused siRNA miniscreen that the synergistic action of the BH3-only proteins Bim and...
- 18From: PLoS Pathogens. (Vol. 5, Issue 3) Peer-ReviewedIn response to numerous signals, latent herpesvirus genomes abruptly switch their developmental program, aborting stable host-cell colonization in favor of productive viral replication that ultimately destroys the cell....
- 19From: PLoS Pathogens. (Vol. 5, Issue 3) Peer-ReviewedGram-negative bacteria-producing extended-spectrum β-lactamases (ESBLs) are found to be truly multiresistant pathogens causing severe clinical problems. In our investigations, fifteen class C β-lactamases with extended...
- 20From: PLoS Pathogens. (Vol. 5, Issue 3) Peer-ReviewedVirtually all cells living in multicellular structures such as tissues and organs are encased in an extracellular matrix. One of the most important features of a biofilm is the extracellular polymeric substance that...