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- 1From: PLoS Genetics. (Vol. 5, Issue 12) Peer-ReviewedThe onset of prezygotic and postzygotic barriers to gene flow between populations is a hallmark of speciation. One of the earliest postzygotic isolating barriers to arise between incipient species is the sterility of...
- 2From: PLoS Genetics. (Vol. 5, Issue 12) Peer-ReviewedGenomic imprinting is an epigenetic process leading to parent-of-origin-specific DNA methylation and gene expression. To date, ~60 imprinted human genes are known. Based on genome-wide methylation analysis of a patient...
- 3From: PLoS Genetics. (Vol. 5, Issue 12) Peer-ReviewedAn accurate and precisely annotated genome assembly is a fundamental requirement for functional genomic analysis. Here, the complete DNA sequence and gene annotation of mouse Chromosome 11 was used to test the efficacy...
- 4From: PLoS Genetics. (Vol. 5, Issue 12) Peer-ReviewedCircadian pacemakers are essential to synchronize animal physiology and behavior with the day:night cycle. They are self-sustained, but the phase of their oscillations is determined by environmental cues, particularly...
- 5From: PLoS Genetics. (Vol. 5, Issue 12) Peer-ReviewedSpinal muscular atrophy is a severe motor neuron disease caused by inactivating mutations in the SMN1 gene leading to reduced levels of full-length functional SMN protein. SMN is a critical mediator of spliceosomal...
- 6From: PLoS Genetics. (Vol. 5, Issue 12) Peer-ReviewedOsteogenesis Imperfecta (OI) is a human syndrome characterized by exquisitely fragile bones due to osteoporosis. The majority of autosomal dominant OI cases result from point or splice site mutations in the type I...
- 7From: PLoS Genetics. (Vol. 5, Issue 12) Peer-ReviewedDerepression of transposable elements (TES) in the course of epigenetic reprogramming of the mouse embryonic germline necessitates the existence of a robust defense that is comprised of PIWI/piRNA pathway and de nova...
- 8From: PLoS Genetics. (Vol. 5, Issue 12) Peer-ReviewedAging involves a progressive physiological remodeling that is controlled by both genetic and environmental factors. Many of these factors impact also on white adipose tissue (WAT), which has been shown to be a...
- 9From: PLoS Genetics. (Vol. 5, Issue 12) Peer-ReviewedRecently, thanks to the increasing throughput of new technologies, we have begun to explore the full extent of alternative pre-mRNA splicing (AS) in the human transcriptome. This is unveiling a vast layer of complexity...
- 10From: PLoS Genetics. (Vol. 5, Issue 12) Peer-ReviewedFemale reproductive cessation is one of the earliest age-related declines humans experience, occurring in mid- adulthood. Similarly, Coenorhabditis elegans' reproductive span is short relative to its total life span,...
- 11From: PLoS Genetics. (Vol. 5, Issue 12) Peer-ReviewedWith multiple genome-wide association studies (GWAS) performed across autoimmune diseases, there is a great opportunity to study the homogeneity of genetic architectures across autoimmune disease. Previous approaches...
- 12From: PLoS Genetics. (Vol. 5, Issue 12) Peer-ReviewedThe origin recognition complex (ORC) marks chromosomal sites as replication origins and is essential for replication initiation. In yeast, ORC also binds to DNA elements called silencers, where its primary function is...
- 13From: PLoS Genetics. (Vol. 5, Issue 12) Peer-ReviewedPhenotypic variation within an isogenic bacterial population is thought to ensure the survival of a subset of cells in adverse conditions. The opportunistic pathogen Pseudomonas aeruginoso variably expresses several...
- 14From: PLoS Genetics. (Vol. 5, Issue 12) Peer-ReviewedThe adipocyte-derived protein adiponectin is highly heritable and inversely associated with risk of type 2 diabetes mellitus (T2D) and coronary heart disease (CHID). We meta-analyzed 3 genome-wide association studies...
- 15From: PLoS Genetics. (Vol. 5, Issue 12) Peer-ReviewedThis work demonstrates how gene association studies can be analyzed to map a global landscape of genetic interactions among protein complexes and pathways. Despite the immense potential of gene association studies, they...
- 16From: PLoS Genetics. (Vol. 5, Issue 12) Peer-ReviewedThe cuticle covering plants' aerial surfaces is a unique structure that plays a key role in organ development and protection against diverse stress conditions. A detailed analysis of the tomato colorless-peel y mutant...
- 17From: PLoS Genetics. (Vol. 5, Issue 12) Peer-ReviewedComparisons between diverse vertebrate genomes have uncovered thousands of highly conserved non-coding sequences, an increasing number of which have been shown to function as enhancers during early development. Despite...
- 18From: PLoS Genetics. (Vol. 5, Issue 12) Peer-ReviewedHuntington's disease (HD) is a progressive neurodegenerative disorder caused by expansion of an unstable CAG repeat in the coding sequence of the Huntingtin (HTT) gene. Instability affects both germline and somatic...
- 19From: PLoS Genetics. (Vol. 5, Issue 12) Peer-ReviewedBacteria can survive antibiotic treatment without acquiring heritable antibiotic resistance. We investigated persistence to the fluoroquinolone ciprofloxacin in Escherichia coli. Our data show that a majority of...
- 20From: PLoS Genetics. (Vol. 5, Issue 12) Peer-ReviewedIntegrating conjugative elements (ICES) are a class of bacterial mobile genetic elements that disseminate via conjugation and then integrate into the host cell genome. The SXT/R391 family of ICES consists of more than...