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- Search Terms:ISSN: 1553734XAndISSN: 15537358AndVolume Number: 5AndIssue Number: 12AndStart Page: e1000593AndDate: 2009 Revise Search
- 1From: PLoS Computational Biology. (Vol. 5, Issue 12) Peer-ReviewedThe evolution of cooperation described in terms of simple two-person interactions has received considerable attention in recent years, where several key results were obtained. Among those, it is now well established...
- 2From: PLoS Computational Biology. (Vol. 5, Issue 12) Peer-ReviewedRapid arterial [O.sub.2] desaturation during apnea in the preterm infant has obvious clinical implications but to date no adequate explanation for why it exists. Understanding the factors influencing the rate of...
- 3From: PLoS Computational Biology. (Vol. 5, Issue 12) Peer-ReviewedThe interaction of proteins at cellular interfaces is critical for many biological processes, from intercellular signaling to cell adhesion. For example, the Selectin family of adhesion receptors plays a critical role...
- 4From: PLoS Computational Biology. (Vol. 5, Issue 12) Peer-ReviewedRepresenting and analyzing complex networks remains a roadblock to creating dynamic network models of biological processes and pathways. The study of cell fate transitions can reveal much about the transcriptional...
- 5From: PLoS Computational Biology. (Vol. 5, Issue 12) Peer-ReviewedTransitive inference, class inclusion and a variety of other inferential abilities have strikingly similar developmental profiles--all are acquired around the age of five. Yet, little is known about the reasons for this...
- 6From: PLoS Computational Biology. (Vol. 5, Issue 12) Peer-ReviewedVascular endothelial growth factor (VEGF) is a potent cytokine that binds to specific receptors on the endothelial cells lining blood vessels. The signaling cascade triggered eventually leads to the formation of new...
- 7From: PLoS Computational Biology. (Vol. 5, Issue 12) Peer-ReviewedIntroduction This tutorial is intended for biologists and computational biologists interested in adding text mining tools to their bioinformatics toolbox. As an illustrative example, the tutorial examines the...
- 8From: PLoS Computational Biology. (Vol. 5, Issue 12) Peer-ReviewedIncreased production of reactive oxygen species (ROS) in mitochondria underlies major systemic diseases, and this clinical problem stimulates a great scientific interest in the mechanism of ROS generation. However, the...
- 9From: PLoS Computational Biology. (Vol. 5, Issue 12) Peer-ReviewedMany patterns of affiliative behaviour have been described for primates, for instance: reciprocation and exchange of grooming, grooming others of similar rank, reconciliation of fights, and preferential reconciliation...
- 10From: PLoS Computational Biology. (Vol. 5, Issue 12) Peer-ReviewedChanges of synaptic connections between neurons are thought to be the physiological basis of learning. These changes can be gated by neuromodulators that encode the presence of reward. We study a family of...
- 11From: PLoS Computational Biology. (Vol. 5, Issue 12) Peer-Reviewed
Dissecting early differentially expressed genes in a mixture of differentiating embryonic stem cells
The differentiation of embryonic stem cells is initiated by a gradual loss of pluripotency-associated transcripts and induction of differentiation genes. Accordingly, the detection of differentially expressed genes at... - 12From: PLoS Computational Biology. (Vol. 5, Issue 12) Peer-Reviewed
Challenges predicting ligand-receptor interactions of promiscuous proteins: the nuclear receptor PXR
Transcriptional regulation of some genes involved in xenobiotic detoxification and apoptosis is performed via the human pregnane X receptor (PXR) which in turn is activated by structurally diverse agonists including... - 13From: PLoS Computational Biology. (Vol. 5, Issue 12) Peer-ReviewedThe neuronal processing of visual stimuli in primary visual cortex (V1) can be modified by perceptual training. Training in bisection discrimination, for instance, changes the contextual interactions in V1 elicited by...
- 14From: PLoS Computational Biology. (Vol. 5, Issue 12) Peer-ReviewedUnderstanding the mechanisms of cell function and drug action is a major endeavor in the pharmaceutical industry. Drug effects are governed by the intrinsic properties of the drug (i.e., selectivity and potency) and the...
- 15From: PLoS Computational Biology. (Vol. 5, Issue 12) Peer-ReviewedCalmodulin kinase II (CaMKII) mediates critical signaling pathways responsible for divergent functions in the heart including calcium cycling, hypertrophy and apoptosis. Dysfunction in the CaMKII signaling pathway...
- 16From: PLoS Computational Biology. (Vol. 5, Issue 12) Peer-ReviewedIntegrins have emerged as key sensory molecules that translate chemical and physical cues from the extracellular matrix (ECM) into biochemical signals that regulate cell behavior. Integrins function by clustering into...
- 17From: PLoS Computational Biology. (Vol. 5, Issue 12) Peer-ReviewedIntroduction Bioinformatics programming skills are becoming a necessity across many facets of biology and medicine, owed in part to the continuing explosion of biological data aggregation and the complexity and scale...
- 18From: PLoS Computational Biology. (Vol. 5, Issue 12) Peer-ReviewedEvolution is shaping the world around us. At the core of every evolutionary process is a population of reproducing individuals. The outcome of an evolutionary process depends on population structure. Here we provide a...
- 19From: PLoS Computational Biology. (Vol. 5, Issue 12) Peer-ReviewedA large number of experiments have asked to what degree human reaching movements can be understood as being close to optimal in a statistical sense. However, little is known about whether these principles are relevant...
- 20From: PLoS Computational Biology. (Vol. 5, Issue 12) Peer-ReviewedSpike timing dependent plasticity (STDP) has been observed experimentally in vitro and is a widely studied neural algorithm for synaptic modification. While the functional role of STDP has been investigated extensively,...