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- Search Terms:ISSN: 15537390AndISSN: 15537404AndVolume Number: 5AndIssue Number: 11AndStart Page: e1000730AndDate: 2009 Revise Search
- 1From: PLoS Genetics. (Vol. 5, Issue 11) Peer-ReviewedSignaling output of bone morphogenetic proteins (BMPs) is determined by two sets of opposing interactions, one with heterotetrameric complexes of cell surface receptors, the other with secreted antagonists that act as...
- 2From: PLoS Genetics. (Vol. 5, Issue 11) Peer-ReviewedDeacetylases of the Sir2 family regulate lifespan and response to stress. We have examined the evolutionary history of Sir2 and Hst1, which arose by gene duplication in budding yeast and which participate in distinct...
- 3From: PLoS Genetics. (Vol. 5, Issue 11) Peer-ReviewedIn Drosophila, genes expressed in males tend to accumulate on autosomes and are underrepresented on the X chromosome. In particular, genes expressed in testis have been observed to frequently relocate from the X...
- 4From: PLoS Genetics. (Vol. 5, Issue 11) Peer-ReviewedAlthough there are some obvious differences between the X chromosome and the autosomes--such as the X chromosome being present in only one copy in males--the two types of chromosome are remarkably similar in their...
- 5From: PLoS Genetics. (Vol. 5, Issue 11) Peer-ReviewedTransposable elements (TEs) comprise a substantial portion of many eukaryotic genomes and are typically transcriptionally silenced. RNA-dependent RNA polymerase 2 (RDR2) is a component of the RNA-directed DNA...
- 6From: PLoS Genetics. (Vol. 5, Issue 11) Peer-ReviewedMicroRNAs (miRNAs) are small, non-coding RNAs that play essential roles in plant growth, development, and stress response. We conducted a genome-wide survey of maize miRNA genes, characterizing their structure,...
- 7From: PLoS Genetics. (Vol. 5, Issue 11) Peer-ReviewedChanges in tissue homeostasis, acquisition of invasive cell characteristics, and tumor formation can often be linked to the loss of epithelial cell polarity. In carcinogenesis, the grade of neoplasia correlates with...
- 8From: PLoS Genetics. (Vol. 5, Issue 11) Peer-ReviewedThe human testis has almost as high a frequency of alternative splicing events as brain. While not as extensively studied as brain, a few candidate testis-specific splicing regulator proteins have been identified,...
- 9From: PLoS Genetics. (Vol. 5, Issue 11) Peer-ReviewedMost of our understanding of plant genome structure and evolution has come from the careful annotation of small (e.g., 100 kb) sequenced genomic regions or from automated annotation of complete genome sequences. Here,...
- 10From: PLoS Genetics. (Vol. 5, Issue 11) Peer-ReviewedFor genome-wide association studies in family-based designs, we propose a new, universally applicable approach. The new test statistic exploits all available information about the association, while, by virtue of its...
- 11From: PLoS Genetics. (Vol. 5, Issue 11) Peer-ReviewedPolyamines are known to play important roles in the proliferation and differentiation of many types of cells. Although considerable amounts of polyamines are synthesized and stored in the testes, their roles remain...
- 12From: PLoS Genetics. (Vol. 5, Issue 11) Peer-ReviewedWhile conventional LDL-C, HDL-C, and triglyceride measurements reflect aggregate properties of plasma lipoprotein fractions, NMR-based measurements more accurately reflect lipoprotein particle concentrations according...
- 13From: PLoS Genetics. (Vol. 5, Issue 11) Peer-ReviewedDNA double-strand breaks (DSBs) are formed during meiosis by the action of the topoisomerase-like Spo11/Rec12 protein, which remains covalently bound to the 5' ends of the broken DNA. Spo11/Rec12 removal is required for...
- 14From: PLoS Genetics. (Vol. 5, Issue 11) Peer-ReviewedIt is a long-held belief in evolutionary biology that the rate of molecular evolution for a given DNA sequence is inversely related to the level of functional constraint. This belief holds true for the protein-coding...
- 15From: PLoS Genetics. (Vol. 5, Issue 11) Peer-ReviewedFollowing the domestication of maize over the past ~10,000 years, breeders have exploited the extensive genetic diversity of this species to mold its phenotype to meet human needs. The extent of structural variation,...
- 16From: PLoS Genetics. (Vol. 5, Issue 11) Peer-ReviewedMicrobial populations founded by a single clone and propagated under resource limitation can become polymorphic. We sought to elucidate genetic mechanisms whereby a polymorphism evolved in Escherichia coli under glucose...
- 17From: PLoS Genetics. (Vol. 5, Issue 11) Peer-ReviewedWilms' tumour (WT) is a pediatric tumor of the kidney that arises via failure of the fetal developmental program. The absence of identifiable mutations in the majority of WTs suggests the frequent involvement of...
- 18From: PLoS Genetics. (Vol. 5, Issue 11) Peer-ReviewedFull-length cDNA (FLcDNA) sequencing establishes the precise primary structure of individual gene transcripts. From two libraries representing 27 B73 tissues and abiotic stress treatments, 27,455 high-quality FLcDNAs...
- 19From: PLoS Genetics. (Vol. 5, Issue 11) Peer-ReviewedThe key molecular event that marks entry into the cell cycle is transcription of G1 cyclins, which bind and activate cyclin-dependent kinases. In yeast cells, initiation of G1 cyclin transcription is linked to...
- 20From: PLoS Genetics. (Vol. 5, Issue 11) Peer-ReviewedIntegrative analysis of gene dosage, expression, and ontology (GO) data was performed to discover driver genes in the carcinogenesis and chemoradioresistance of cervical cancers. Gene dosage and expression profiles of...