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- 1From: PLoS Medicine. (Vol. 5, Issue 11) Peer-ReviewedBackground to the debate: The global burden of disease falls disproportionately upon the world's low-income countries, which are often struggling with weak health systems. Both the public and private sector deliver...
- 2From: PLoS Medicine. (Vol. 5, Issue 11) Peer-ReviewedIn January 2008, in an article entitled "The Starvelings," The Economist made the case that childhood hunger and malnutrition have a far greater impact upon child health than was previously thought [1]. The most recent...
- 3From: PLoS Medicine. (Vol. 5, Issue 11) Peer-ReviewedBackground Peer-led sex education is widely believed to be an effective approach to reducing unsafe sex among young people, but reliable evidence from long-term studies is lacking. To assess the effectiveness of one...
- 4From: PLoS Medicine. (Vol. 5, Issue 11) Peer-ReviewedIt is almost ten years since a clarion call was sounded to malaria researchers, funding agencies, governments, and international organisations to help avert "a malaria disaster" [1]. At that time, infrastructure in...
- 5From: PLoS Medicine. (Vol. 5, Issue 11) Peer-ReviewedIntroduction Prevention of early, unintended pregnancy, abortions, and sexually transmitted infections among adolescents is a very high priority in the United States and Europe, and the United Kingdom has a target to...
- 6From: PLoS Medicine. (Vol. 5, Issue 11) Peer-ReviewedBackground Artemisinin derivatives used in recently introduced combination therapies (ACTs) for Plasmodium falciparum malaria significantly lower patient infectiousness and have the potential to reduce...
- 7From: PLoS Medicine. (Vol. 5, Issue 11) Peer-ReviewedBackground Previous studies of drug trials submitted to regulatory authorities have documented selective reporting of both entire trials and favorable results. The objective of this study is to determine the...
- 8From: PLoS Medicine. (Vol. 5, Issue 11) Peer-ReviewedBackground Envenoming resulting from snakebites is an important public health problem in many tropical and subtropical countries. Few attempts have been made to quantify the burden, and recent estimates all suffer...
- 9From: PLoS Medicine. (Vol. 5, Issue 11) Peer-ReviewedLack of Antivenom: A Market Failure Snakebite is a common medical emergency in developing countries in tropical regions. The only specific treatment is antivenom [1], but this is often unavailable in remote health...
- 10From: PLoS Medicine. (Vol. 5, Issue 11) Peer-ReviewedBackground Resistance to triazoles was recently reported in Aspergillus fumigatus isolates cultured from patients with invasive aspergillosis. The prevalence of azole resistance in A. fumigatus is unknown. We...
- 11From: PLoS Medicine. (Vol. 5, Issue 11) Peer-ReviewedThe renewed focus on malaria control and eradication in recent years has shifted the design of malaria control programs away from short-term, local solutions towards more wide-ranging and long-term strategies. This new...
- 12From: PLoS Medicine. (Vol. 5, Issue 11) Peer-ReviewedPRESENTATION OF CASE In May 2007, a 62-year-old man presented with a 6-cm fungating mass on the dorsum of the tongue (Figure 1), which had lasted for an unknown period of time. The lesion had a roughened and...
- 13From: PLoS Medicine. (Vol. 5, Issue 11) Peer-ReviewedIf a school-age child contracts dengue in rural Thailand, it is difficult to predict whether that child was infected at home, at school, or somewhere else. Therefore it is difficult to know how best to allocate scarce...
- 14From: PLoS Medicine. (Vol. 5, Issue 11) Peer-ReviewedIn 2002, Plasmodium falciparum caused at least 0.5 billion uncomplicated clinical attacks of malaria worldwide, particularly in nonimmune young children living in Africa [1]. Because inadequately treated uncomplicated...
- 15From: PLoS Medicine. (Vol. 5, Issue 11) Peer-ReviewedBackground Can political controversy have a "chilling effect" on the production of new science? This is a timely concern, given how often American politicians are accused of undermining science for political...
- 16From: PLoS Medicine. (Vol. 5, Issue 11) Peer-ReviewedIntroduction A 9-year-old with cerebral palsy received an injection of the neurotoxin "Botox" to relieve muscle spasms. This off-label use was legal but not approved by the US Food and Drug Administration (FDA) for...
- 17From: PLoS Medicine. (Vol. 5, Issue 11) Peer-ReviewedAlthough randomized trials provide key guidance for how we practice medicine, trust in their published results has been eroded in recent years due to several high-profile cases of alleged data suppression,...
- 18From: PLoS Medicine. (Vol. 5, Issue 11) Peer-ReviewedBackground Transmission of dengue viruses (DENV), the leading cause of arboviral disease worldwide, is known to vary through time and space, likely owing to a combination of factors related to the human host, virus,...