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Academic Journals
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- Search Terms:ISSN: 15537390AndISSN: 15537404AndVolume Number: 5AndIssue Number: 10AndStart Page: e1000677AndDate: 2009 Revise Search
- 1From: PLoS Genetics. (Vol. 5, Issue 10) Peer-ReviewedThere are two main classes of natural killer (NK) cell receptors in mammals, the killer cell immunoglobulin-like receptors (KIR) and the structurally unrelated killer cell lectin-like receptors (KLR). While KIR...
- 2From: PLoS Genetics. (Vol. 5, Issue 10) Peer-ReviewedThe TOCA family of F-BAR-containing proteins bind to and remodel lipid bilayers via their conserved F-BAR domains, and regulate actin dynamics via their N-Wasp binding SH3 domains. Thus, these proteins are predicted to...
- 3From: PLoS Genetics. (Vol. 5, Issue 10) Peer-ReviewedThe INSIG2 rs7566605 polymorphism was identified for obesity (BMI [greater than or equal to] 30 kg/[m.sup.2]) in one of the first genome-wide association studies, but replications were inconsistent. We collected...
- 4From: PLoS Genetics. (Vol. 5, Issue 10) Peer-ReviewedFor most organisms, chemosensation is critical for survival and is mediated by large families of Chemoreceptor proteins, whose expression must be tuned appropriately to changes in the chemical environment. We asked...
- 5From: PLoS Genetics. (Vol. 5, Issue 10) Peer-ReviewedIt is estimated that a large proportion of amino acid substitutions in Drosophila have been fixed by natural selection, and as organisms are faced with an ever-changing array of pathogens and parasites to which they...
- 6From: PLoS Genetics. (Vol. 5, Issue 10) Peer-ReviewedSphingolipids have essential roles as structural components of cell membranes and in cell signalling, and disruption of their metabolism causes several diseases, with diverse neurological, psychiatric, and metabolic...
- 7From: PLoS Genetics. (Vol. 5, Issue 10) Peer-ReviewedKidneys age at different rates, such that some people show little or no effects of aging whereas others show rapid functional decline. We sequentially used transcriptional profiling and expression quantitative trait...
- 8From: PLoS Genetics. (Vol. 5, Issue 10) Peer-ReviewedDefining the molecular structure and function of synapses is a central theme in brain research. In Drosophila the Bruchpilot (BRP) protein is associated with T-shaped ribbons ("T-bars") at presynaptic active zones...
- 9From: PLoS Genetics. (Vol. 5, Issue 10) Peer-ReviewedA role for variant histone H2A.Z in gene expression is now well established but little is known about the mechanisms by which it operates. Using a combination of ChIP-chip, knockdown and expression profiling...
- 10From: PLoS Genetics. (Vol. 5, Issue 10) Peer-ReviewedMetagenomic sequencing projects from environments dominated by a small number of species produce genome-wide population samples. We present a two-site composite likelihood estimator of the scaled recombination rate,...
- 11From: PLoS Genetics. (Vol. 5, Issue 10) Peer-ReviewedMycoplasma hominis is an opportunistic human mycoplasma. Two other pathogenic human species, M, genitalium and Ureaplasma parvum, reside within the same natural niche as M, hominis: the urogenital tract. These three...
- 12From: PLoS Genetics. (Vol. 5, Issue 10) Peer-ReviewedThe plant-specific RNA polymerases Pol IV and Pol V are essential to RNA-directed DNA methylation (RdDM), which also requires activities from RDR2 (RNA-Dependent RNA Polymerase 2), DCL3 (Dicer-Like 3), AG04 (Argonaute),...
- 13From: PLoS Genetics. (Vol. 5, Issue 10) Peer-ReviewedThe p53 family activates many of the same genes in response to DNA damage. Because p63 and p73 have structural differences from p53 and play distinct biological functions in development and metastasis, it is likely that...
- 14From: PLoS Genetics. (Vol. 5, Issue 10) Peer-ReviewedMeiotic crossovers are produced when programmed double-strand breaks (DSBs) are repaired by recombination from homologous chromosomes (homologues). In a wide variety of organisms, meiotic HORMA-domain proteins are...
- 15From: PLoS Genetics. (Vol. 5, Issue 10) Peer-ReviewedPathologies caused by mutations in extracellular matrix proteins are generally considered to result from the synthesis of extracellular matrices that are defective. Mutations in type X collagen cause metaphyseal...
- 16From: PLoS Genetics. (Vol. 5, Issue 10) Peer-ReviewedThe proper assembly of the Synaptonemal complex (SC) between homologs is critical to ensure accurate meiotic chromosome segregation. The SC is a meiotic tripartite structure present from yeast to humans, comprised of...
- 17From: PLoS Genetics. (Vol. 5, Issue 10) Peer-ReviewedTrinucleotide repeat expansion is the genetic basis for a sizeable group of inherited neurological and neuromuscular disorders. Friedreich ataxia (FRDA) is a relentlessly progressive neurodegenerative disorder caused by...
- 18From: PLoS Genetics. (Vol. 5, Issue 10) Peer-ReviewedThe RpoS sigma factor protein of Escherichia coli RNA polymerase is the master transcriptional regulator of physiological responses to a variety of stresses. This stress response comes at the expense of scavenging for...
- 19From: PLoS Genetics. (Vol. 5, Issue 10) Peer-ReviewedPeroxiredoxins are a family of antioxidant enzymes critically involved in cellular defense and signaling. Particularly, yeast peroxiredoxin Tsa1p is thought to play a role in the maintenance of genome integrity, but the...
- 20From: PLoS Genetics. (Vol. 5, Issue 10) Peer-ReviewedHistone chaperones CAF-1 and Asf1 function to deposit newly synthesized histones onto replicating DNA to promote nucleosome formation in a proliferating cell nuclear antigen (PCNA) dependent process. The DNA...