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- Search Terms:ISSN: 15537366AndISSN: 15537374AndVolume Number: 5AndIssue Number: 10AndStart Page: e1000609AndDate: 2009 Revise Search
- 1From: PLoS Pathogens. (Vol. 5, Issue 10) Peer-ReviewedGroup A human rotaviruses (RVs) are a major cause of severe gastroenteritis in infants and young children. Yet, aside from the genes encoding serotype antigens (VP7; G-type and VP4; P-type), little is known about the...
- 2From: PLoS Pathogens. (Vol. 5, Issue 10) Peer-Reviewed
Equine rhinitis A virus and its low pH empty particle: clues towards an Aphthovirus entry mechanism?
Equine rhinitis A virus (ERAV) is closely related to foot-and-mouth disease virus (FMDV), belonging to the genus Aphthovirus of the Picornaviridae. How picornaviruses introduce their RNA genome into the cytoplasm of the... - 3From: PLoS Pathogens. (Vol. 5, Issue 10) Peer-ReviewedInterferon regulatory factors (IRF)-3 and IRF-7 are master transcriptional factors that regulate type I IFN gene (IFN-[alpha]/[beta] induction and innate immune defenses after virus infection. Prior studies in mice with...
- 4From: PLoS Pathogens. (Vol. 5, Issue 10) Peer-ReviewedAlpha-herpesvi ruses, including human herpes simplex virus 1 & 2, varicella zoster virus and the swine pseudorabies virus (PRV), infect the peripheral nervous system of their hosts. Symptoms of infection often include...
- 5From: PLoS Pathogens. (Vol. 5, Issue 10) Peer-ReviewedThe enormous toll on human life during the 1918-1919 Spanish influenza pandemic is a constant reminder of the potential lethality of influenza viruses. With the declaration by the World Health Organization of a new H1N1...
- 6From: PLoS Pathogens. (Vol. 5, Issue 10) Peer-ReviewedOnce transcribed, the nascent full-length RNA of HIV-1 must travel to the appropriate host cell sites to be translated or to find a partner RNA for copackaging to form newly generated viruses. In this report, we sought...
- 7From: PLoS Pathogens. (Vol. 5, Issue 10) Peer-ReviewedMonocyte (MO) subpopulations display distinct phenotypes and functions which can drastically change during inflammatory states. We hypothesized that discrete MO subpopulations are induced during malaria infection and...
- 8From: PLoS Pathogens. (Vol. 5, Issue 10) Peer-ReviewedMechanisms for differential regulation of gene expression may underlie much of the phenotypic variation and adaptability of malaria parasites. Here we describe transcriptional variation among culture-adapted field...
- 9From: PLoS Pathogens. (Vol. 5, Issue 10) Peer-ReviewedThe bacterium Helicobacter pylori can cause peptic ulcer disease, gastric adenocarcinoma and MALT lymphoma. The cell-surface mucin MUC1 is a large glycoprotein which is highly expressed on the mucosal surface and limits...
- 10From: PLoS Pathogens. (Vol. 5, Issue 10) Peer-ReviewedVirus-Induced Chaperone-Enriched (VICE) domains form adjacent to nuclear viral replication compartments (RC) during the early stages of HSV-1 infection. Between 2 and 3 hours post infection at a MOI of 10, host protein...
- 11From: PLoS Pathogens. (Vol. 5, Issue 10) Peer-ReviewedSince Kaposi's sarcoma-associated herpesvirus (KSHV or human herpesvirus 8) was first identified in Kaposi's sarcoma (KS) lesions of HIV-infected individuals with AIDS, the basic biological understanding of KSHV has...
- 12From: PLoS Pathogens. (Vol. 5, Issue 10) Peer-ReviewedHIV fusion and entry into CD4 T cells are mediated by two receptors, CD4 and CXCR4. This receptor requirement can be abrogated by pseudotyping the virion with the vesicular stomatitis virus glycoprotein (VSV-G) that...
- 13From: PLoS Pathogens. (Vol. 5, Issue 10) Peer-ReviewedNasal colonization by both gram-positive and gram-negative pathogens induces expression of the innate immune protein lipocalin 2 (Lcn2). Lcn2 binds and sequesters the iron-scavenging siderophore enterobactin (Ent),...
- 14From: PLoS Pathogens. (Vol. 5, Issue 10) Peer-ReviewedMycobacteria, such as the etiological agent of human tuberculosis, Mycobacterium tuberculosis, are protected by an impermeable cell envelope composed of an inner cytoplasmic membrane, a peptidoglycan layer, an...
- 15From: PLoS Pathogens. (Vol. 5, Issue 10) Peer-Reviewed[gamma]-herpesviruses ([gamma]HVs) have developed an interaction with their hosts wherein they establish a life-long persistent infection and are associated with the onset of various malignancies. One critical virulence...
- 16From: PLoS Pathogens. (Vol. 5, Issue 10) Peer-ReviewedParasites have kept many secrets from the researchers who have sought to eradicate them over past decades. The mechanisms by which they evade drugs, escape the immune system, regulate switching between genes involved in...
- 17From: PLoS Pathogens. (Vol. 5, Issue 10) Peer-ReviewedInfluenza A virus causes annual epidemics and occasional pandemics of short-term respiratory infections associated with considerable morbidity and mortality. The pandemics occur when new human-transmissible viruses that...
- 18From: PLoS Pathogens. (Vol. 5, Issue 10) Peer-ReviewedGlycolysis is a metabolic pathway that is central to the assimilation of carbon for either respiration or fermentation and therefore is critical for the growth of all organisms. Consequently, glycolytic transcriptional...
- 19From: PLoS Pathogens. (Vol. 5, Issue 10) Peer-ReviewedTo mate, MTL-homozygous strains of the yeast pathogen Candida albicans must switch from the white to opaque phase. Mating-competent opaque cells then release pheromone that induces polarization, a G1 block and...
- 20From: PLoS Pathogens. (Vol. 5, Issue 10) Peer-ReviewedDimorphism or morphogenic conversion is exploited by several pathogenic fungi and is required for tissue invasion and/or survival in the host. We have identified a homolog of a master regulator of this morphological...