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- Search Terms:ISSN: 15537390AndISSN: 15537404AndVolume Number: 5AndIssue Number: 1AndStart Page: e1000342AndDate: 2009 Revise Search
- 1From: PLoS Genetics. (Vol. 5, Issue 1) Peer-ReviewedDespite having only begun ~10,000 years ago, the process of domestication has resulted in a degree of phenotypic variation within individual species normally associated with much deeper evolutionary time scales. Though...
- 2From: PLoS Genetics. (Vol. 5, Issue 1) Peer-ReviewedChromosome structural changes with nonrecurrent endpoints associated with genomic disorders offer windows into the mechanism of origin of copy number variation (CNV). A recent report of nonrecurrent duplications...
- 3From: PLoS Genetics. (Vol. 5, Issue 1) Peer-ReviewedSeed size is a key determinant of evolutionary fitness in plants and is a trait that often undergoes tremendous changes during crop domestication. Seed size is most often quantitatively inherited, and it has been shown...
- 4From: PLoS Genetics. (Vol. 5, Issue 1) Peer-ReviewedPersistently low white blood cell count (WBC) and neutrophil count is a well-described phenomenon in persons of African ancestry, whose etiology remains unknown. We recently used admixture mapping to identify an...
- 5From: PLoS Genetics. (Vol. 5, Issue 1) Peer-ReviewedPolyunsaturated fatty acids (PUFA) have a role in many physiological processes, including energy production, modulation of inflammation, and maintenance of cell membrane integrity. High plasma PUFA concentrations have...
- 6From: PLoS Genetics. (Vol. 5, Issue 1) Peer-ReviewedGenetic screens are powerful methods for the discovery of gene--phenotype associations. However, a systems biology approach to genetics must leverage the massive amount of "omics" data to enhance the power and speed of...
- 7From: PLoS Genetics. (Vol. 5, Issue 1) Peer-ReviewedThe related PIK-like kinases Ataxia-Telangiectasia Mutated (ATM) and ATM- and Rad3-related (ATR) play major roles in the regulation of cellular responses to DNA damage or replication stress. The pro-apoptotic role of ATM...
- 8From: PLoS Genetics. (Vol. 5, Issue 1) Peer-ReviewedA major task in human genetics is to understand the nature of the evolutionary processes that have shaped the gene pools of contemporary populations. Ancient DNA studies have great potential to shed light on the...
- 9From: PLoS Genetics. (Vol. 5, Issue 1) Peer-ReviewedOne of the few commonly believed principles of molecular evolution is that functionally more important genes (or DNA sequences) evolve more slowly than less important ones. This principle is widely used by molecular...
- 10From: PLoS Genetics. (Vol. 5, Issue 1) Peer-ReviewedThe identification of recessive disease-causing genes by homozygosity mapping is often restricted by lack of suitable consanguineous families. To overcome these limitations, we apply homozygosity mapping to single...
- 11From: PLoS Genetics. (Vol. 5, Issue 1) Peer-ReviewedThe evolution of degenerate characteristics remains a poorly understood phenomenon. Only recently has the identification of mutations underlying regressive phenotypes become accessible through the use of genetic...
- 12From: PLoS Genetics. (Vol. 5, Issue 1) Peer-ReviewedThe high-density clustering of voltage-gated [Na.sup.+] channels and KCNQ2/3 [K.sup.+] channels at the axon initial segment (AIS; see Figure 1A) and nodes of Ranvier (Figure 1B) is essential for the final integration of...
- 13From: PLoS Genetics. (Vol. 5, Issue 1) Peer-ReviewedThe Escherichia coli species represents one of the best-studied model organisms, but also encompasses a variety of commensal and pathogenic strains that diversify by high rates of genetic change. We uniformly (re-)...
- 14From: PLoS Genetics. (Vol. 5, Issue 1) Peer-ReviewedHuman tumors that lack telomerase maintain telomeres by alternative lengthening mechanisms. Tumors can also form in telomerase-deficient mice; however, the genetic mechanism responsible for tumor growth without...
- 15From: PLoS Genetics. (Vol. 5, Issue 1) Peer-ReviewedNon-coding RNA (ncRNA) play an important and varied role in cellular function. A significant amount of research has been devoted to computational prediction of these genes from genomic sequence, but the ability to do so...
- 16From: PLoS Genetics. (Vol. 5, Issue 1) Peer-ReviewedKawasaki disease (KD) is a pediatric vasculitis that damages the coronary arteries in 25% of untreated and approximately 5% of treated children. Epidemiologic data suggest that KD is triggered by unidentified...
- 17From: PLoS Genetics. (Vol. 5, Issue 1) Peer-Reviewed
A cis-acting diversification activator both necessary and sufficient for AID-mediated hypermutation.
Hypermutation of the immunoglobulin (Ig) genes requires Activation Induced cytidine Deaminase (AID) and transcription, but it remains unclear why other transcribed genes of B cells do not mutate. We describe a reporter... - 18From: PLoS Genetics. (Vol. 5, Issue 1) Peer-ReviewedCharacterization of the evolutionary constraints acting on cis-regulatory sequences is crucial to comparative genomics and provides key insights on the evolution of organismal diversity. We study the relationships among...
- 19From: PLoS Genetics. (Vol. 5, Issue 1) Peer-ReviewedIn many mammalian neurons, dense clusters of ion channels at the axonal initial segment and nodes of Ranvier underlie action potential generation and rapid conduction. Axonal clustering of mammalian voltage-gated sodium...
- 20From: PLoS Genetics. (Vol. 5, Issue 1) Peer-ReviewedThe nature of toxic effects exerted on neurons by misfolded proteins, occurring in a number of neurodegenerative diseases, is poorly understood. One approach to this problem is to measure effects when such proteins are...