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- Search Terms:ISSN: 15491277AndISSN: 15491676AndVolume Number: 5AndIssue Number: 1AndStart Page: e4AndDate: 2008 Revise Search
- 1From: PLoS Medicine. (Vol. 5, Issue 1) Peer-ReviewedIn the late 1950s, the late Democratic Senator Estes Kefauver, Chairman of the United States Senate's Anti-Trust and Monopoly Subcommittee, put together the first extensive indictment against the business workings of...
- 2From: PLoS Medicine. (Vol. 5, Issue 1) Peer-ReviewedCorrection for: Yates A, Stark J, Klein N, Antia R, Callard R (2007) Understanding the slow depletion of memory CD4+ T cells in HIV infection. PLoS Med 4(5): e177. doi:10.1371/journal.pmed.0040177 In the published...
- 3From: PLoS Medicine. (Vol. 5, Issue 1) Peer-ReviewedBackground Clear, transparent, and sufficiently detailed abstracts of conferences and journal articles related to randomized controlled trials (RCTs) are important, because readers often base their assessment of a...
- 4From: PLoS Medicine. (Vol. 5, Issue 1) Peer-Reviewed
Targeting PDGF signaling in carcinoma-associated fibroblasts controls cervical cancer in mouse model
Cervical cancer is one of the most prevalent malignancies in women worldwide and is the leading cause of cancer death for women in developing countries [1]. While early detection via the Pap test as well as treatment by... - 5From: PLoS Medicine. (Vol. 5, Issue 1) Peer-ReviewedBackground There is much discussion in the cancer drug development community about how to incorporate molecular tools into early-stage clinical trials to assess target modulation, measure anti-tumor activity, and...
- 6From: PLoS Medicine. (Vol. 5, Issue 1) Peer-ReviewedDuring the past several decades, and with an accelerating pace in the past several years, a primary focus of cancer research and treatment has been the development and refinement of specific, biologically directed...
- 7From: PLoS Medicine. (Vol. 5, Issue 1) Peer-Reviewed
Antiretroviral pre-exposure prophylaxis prevents vaginal transmission of HIV-1 in humanized BLT mice
Background Worldwide, vaginal transmission now accounts for more than half of newly acquired HIV-1 infections. Despite the urgency to develop and implement novel approaches capable of preventing HIV transmission,... - 8From: PLoS Medicine. (Vol. 5, Issue 1) Peer-ReviewedSchistosomiasis is a tropical disease of great antiquity that remains endemic in 76 countries, affecting 200 to 300 million people in the developing world. Current control of schistosomiasis is heavily dependent on...
- 9From: PLoS Medicine. (Vol. 5, Issue 1) Peer-ReviewedBackground Staphylococcus aureus permanently colonizes the vestibulum nasi of one-fifth of the human population, which is a risk factor for autoinfection. The precise mechanisms whereby S. aureus colonizes the nose...
- 10From: PLoS Medicine. (Vol. 5, Issue 1) Peer-ReviewedA research article by Kay-Tee Khaw and colleagues in this issue of PLoS Medicine [1] quantifies the benefits of adopting not just one but four healthy forms of behavior. Compared with people who do not engage in any of...
- 11From: PLoS Medicine. (Vol. 5, Issue 1) Peer-ReviewedGlucose is the most rapidly accessible substrate in the body. Its storage as glycogen in muscle and liver is of central importance as a first source of energy for muscle contractions and prevention against hypoglycemia....
- 12From: PLoS Medicine. (Vol. 5, Issue 1) Peer-ReviewedBackground Important support functions, including promotion of tumor growth, angiogenesis, and invasion, have been attributed to the different cell types populating the tumor stroma, i.e., endothelial cells,...
- 13From: PLoS Medicine. (Vol. 5, Issue 1) Peer-ReviewedThe current debate about the brain drain of health professionals from low-income countries such as Pakistan to the rich world often demonizes medical graduates who choose to leave their countries. Such graduates are...
- 14From: PLoS Medicine. (Vol. 5, Issue 1) Peer-ReviewedBackground to the debate: Systematic reviews that combine high-quality evidence from several trials are now widely considered to be at the top of the hierarchy of clinical evidence. Given the primacy of systematic...
- 15From: PLoS Medicine. (Vol. 5, Issue 1) Peer-ReviewedCorrection for: Holtz TH, Holmes S, Stonington S, Eisenberg L (2006) Health is still social: Contemporary examples in the age of the genome. PLoS Med 3(10): e419. doi:10.1371/journal.pmed.0030419 One of the...
- 16From: PLoS Medicine. (Vol. 5, Issue 1) Peer-ReviewedThe pharmaceutical industry's business model is hefty investment in research and development (R&D), in expectation of high returns from future drug sales during the period of patent protection. This model, which funds...
- 17From: PLoS Medicine. (Vol. 5, Issue 1) Peer-ReviewedBackground Interferon-c receptor 1 (IFN-[gamma]R1) deficiency is a life-threatening inherited disorder, conferring predisposition to mycobacterial diseases. Haematopoietic stem cell transplantation (HSCT) is the only...
- 18From: PLoS Medicine. (Vol. 5, Issue 1) Peer-ReviewedBackground Chlamydia trachomatis is a unique obligate intracellular bacterium that remains the leading cause of sexually transmitted bacterial diseases and preventable blindness worldwide. Chronic ocular infections...
- 19From: PLoS Medicine. (Vol. 5, Issue 1) Peer-ReviewedOver the last few months, the medical community has received both good and bad news concerning the AIDS epidemic. The "good" news: the number of individuals infected with HIV worldwide was revised downward and was...
- 20From: PLoS Medicine. (Vol. 5, Issue 1) Peer-ReviewedBackground Stored glycogen is an important source of energy for skeletal muscle. Human genetic disorders primarily affecting skeletal muscle glycogen turnover are well-recognised, but rare. We previously reported...