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- 1From: Nature Methods. (Vol. 5, Issue 1) Peer-ReviewedLectins are highly specific carbohydrate receptors that are being increasingly applied as tools for carbohydrate detection. Ferrand et al. designed a synthetic lectin analog that can recognize the disaccharide cellobiose...
- 2From: Nature Methods. (Vol. 5, Issue 1) Peer-ReviewedAs the well-established 'bottom-up' mass spectrometry-based approach continues its success in high-throughput proteomics, an emerging approach known as 'top-down' is beginning to make headlines, especially for the...
- 3From: Nature Methods. (Vol. 5, Issue 1) Peer-ReviewedWe have developed a method for integrating three dimensional-volume reconstructions of spatially resolved matrix-assisted laser desorption/ionization imaging mass spectrometry (MALDI IMS) ion images of whole mouse heads...
- 4From: Nature Methods. (Vol. 5, Issue 1) Peer-Reviewed454 technology Sample preparation. Fragments of DNA are ligated to adapters that facilitate their capture on beads (one fragment per bead). A water-in-oil emulsion containing PCR reagents and one bead per droplet is...
- 5From: Nature Methods. (Vol. 5, Issue 1) Peer-ReviewedThe ROSA26 locus in the genome of mouse embryonic stem cells is easy to target and expresses transgenes well. Irion et al. identified the human equivalent of the ROSA26 locus on chromosome 3. They integrated various...
- 6From: Nature Methods. (Vol. 5, Issue 1) Peer-ReviewedWe present a noninvasive approach to track activation of ATP-gated P2X receptors and potentially other transmitter-gated cation channels that show calcium fluxes. We genetically engineered rat P2X receptors to carry...
- 7From: Nature Methods. (Vol. 5, Issue 1) Peer-ReviewedThe importance of microRNAs--short noncoding RNAs that inhibit mRNA expression--is as big as their size is small. They are thought to regulate at least 30% of all human genes and have a crucial role in normal and disease...
- 8From: Nature Methods. (Vol. 5, Issue 1) Peer-ReviewedHaematopoetic stem cells differentiate to give rise to all the cells in the blood. By performing global gene expression analysis on these cells and on their differentiated progeny, Chambers et al. identified molecular...
- 9From: Nature Methods. (Vol. 5, Issue 1) Peer-ReviewedLight is great for looking at things, but it can also be used to alter molecules and by extension control cellular activity. In 2005 a collaboration between the laboratories of Georg Nagel and Karl Deisseroth showed that...
- 10From: Nature Methods. (Vol. 5, Issue 1) Peer-ReviewedThe conditional expression of hairpin constructs in Drosophila melanogaster has emerged in recent years as a method of choice in functional genomic studies. To date, upstream activating site-driven RNA interference...
- 11From: Nature Methods. (Vol. 5, Issue 1) Peer-ReviewedResearchers identify a biomarker for neural progenitor cells and use it to monitor these cells in the live brain. Though it may sometimes seem unlikely that the human brain can generate new neurons--when a name...
- 12From: Nature Methods. (Vol. 5, Issue 1) Peer-ReviewedRobotic liquid dispensers, plate handlers, automated plate readers and scanners are just a few of the instruments designed to make life in the lab simpler for scientists. And although these technologies open new research...
- 13From: Nature Methods. (Vol. 5, Issue 1) Peer-ReviewedWe report a technique for fluorescence tomography that operates beyond the penetration limits of tissue-sectioning fluorescence microscopy. The method uses multi-projection illumination and photon transport description...
- 14From: Nature Methods. (Vol. 5, Issue 1) Peer-ReviewedThe discrete randomization of fluorescent protein expression in neurons creates a Brainbow. Visualizing neural structures is notoriously tricky. Although neurons vary considerably in morphology, they often are large...
- 15From: Nature Methods. (Vol. 5, Issue 1) Peer-ReviewedIf the proverbial blind men were scientists, they would have described their respective parts of the elephant well. Its epigenome, genome, transcriptome, proteome and glycome would continually be analyzed with...
- 16From: Nature Methods. (Vol. 5, Issue 1) Peer-ReviewedGenetic engineering is becoming an information technology. Recent advances in the automated assembly of gene synthesis make ordering a user-defined DNA sequence as easy as ordering a pizza. Already, the exchange of...
- 17From: Nature Methods. (Vol. 5, Issue 1) Peer-ReviewedThe process of development--in which a single-celled zygote changes into a multi-cellular organism--should be, at least in principle, reversible. In the most recent practical demonstration of this prediction, several...
- 18From: Nature Methods. (Vol. 5, Issue 1) Peer-ReviewedThe challenge in observing de novo virus production in human immunodeficiency virus (HIV)-infected dendritic cells (DCs) is the lack of resolution between cytosofic immature and endocytic mature HIV gag protein. To track...
- 19From: Nature Methods. (Vol. 5, Issue 1) Peer-ReviewedWe established a protocol to construct complete recombinant genomes from their small contiguous DNA pieces and obtained the genomes of mouse mitochondrion and rice chloroplast using a B. subtilis genome (BGM) vector....
- 20From: Nature Methods. (Vol. 5, Issue 1) Peer-ReviewedAfter the grandfather of modern microscopy Ernst Abbe formulated the theories that revolutionized modern microscope design, the imposed limits on the spatial resolution were considered inviolable. Over the past decade...