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- 1From: BMC Medical Genomics. (Vol. 5, Issue 1) Peer-ReviewedBackground Imatinib mesylate is currently the drug of choice to treat chronic myeloid leukemia. However, patient resistance and cytotoxicity make secondary lines of treatment, such as omacetaxine mepesuccinate, a...
- 2From: BMC Medical Genomics. (Vol. 5, Issue 1) Peer-ReviewedBackground Aortopathies are a group of disorders characterized by aneurysms, dilation, and tortuosity of the aorta. Because of the phenotypic overlap and genetic heterogeneity of diseases featuring aortopathy,...
- 3From: BMC Medical Genomics. (Vol. 5, Issue 1) Peer-ReviewedBackground The noninvasive prenatal diagnosis procedures that are currently used to detect genetic diseases do not achieve desirable levels of sensitivity and specificity. Recently, fetal methylated DNA biomarkers in...
- 4From: BMC Medical Genomics. (Vol. 5, Issue 1) Peer-ReviewedBackground Batch effects due to sample preparation or array variation (type, charge, and/or platform) may influence the results of microarray experiments and thus mask and/or confound true biological differences. Of...
- 5From: BMC Medical Genomics. (Vol. 5) Peer-ReviewedBackground Liver fibrosis is caused by chemicals or viral infection. The progression of liver fibrosis results in hepatocellular carcinogenesis in later stages. Recent studies have revealed the importance of DNA...
- 6From: BMC Medical Genomics. (Vol. 5, Issue 1) Peer-ReviewedBackground Improved methods are needed for predicting prognosis and the benefit of delivering adjuvant chemotherapy (ACT) in patients with non-small-cell lung cancer (NSCLC). Methods A novel prognostic...
- 7From: BMC Medical Genomics. (Vol. 5, Issue 1) Peer-ReviewedBackground Cancer stem cells (CSCs) are thought to be a source of tumor recurrence due to their stem cell-like properties. MicroRNAs (miRNAs) regulate both normal stem cells and CSCs, and dysregulation of miRNAs has...
- 8From: BMC Medical Genomics. (Vol. 5, Issue 1) Peer-ReviewedBackground Abdominal aortic aneurysm (AAA) is a dilatation of the aorta affecting most frequently elderly men. Histologically AAAs are characterized by inflammation, vascular smooth muscle cell apoptosis, and...
- 9From: BMC Medical Genomics. (Vol. 5, Issue 1) Peer-ReviewedBackground Many methodologies have been used in research to identify the "intrinsic" subtypes of breast cancer commonly known as Luminal A, Luminal B, HER2-Enriched (HER2-E) and Basal-like. The PAM50 gene set is...
- 10From: BMC Medical Genomics. (Vol. 5, Issue 1) Peer-ReviewedBackground While there is strong evidence for phosphatidylinositol 3-kinase (PI3K) involvement in cancer development, there is limited information about the role of PI3K regulatory subunits. PIK3R3, the gene that...
- 11From: BMC Medical Genomics. (Vol. 5, Issue 1) Peer-ReviewedBackground To elucidate gene expression associated with copy number changes, we performed a genome-wide copy number and expression microarray analysis of 25 pairs of gastric tissues. Methods We applied laser...
- 12From: BMC Medical Genomics. (Vol. 5, Issue 1) Peer-ReviewedBackground It is accepted that a woman's lifetime risk of developing breast cancer after menopause is reduced by early full term pregnancy and multiparity. This phenomenon is thought to be associated with the...
- 13From: BMC Medical Genomics. (Vol. 5, Issue 1) Peer-ReviewedBackground Massively-parallel sequencing (MPS) technologies create challenges for informed consent of research participants given the enormous scale of the data and the wide range of potential results. Discussion...
- 14From: BMC Medical Genomics. (Vol. 5, Issue 1) Peer-ReviewedBackground By regulating digestion and absorption of nutrients and providing a barrier against the external environment the intestine provides a crucial contribution to the maintenance of health. To what extent...
- 15From: BMC Medical Genomics. (Vol. 5, Issue 1) Peer-ReviewedBackground Anatomic and physiological similarities to the human make swine an excellent large animal model for human health and disease. Methods Cloning from a modified somatic cell, which can be determined in...
- 16From: BMC Medical Genomics. (Vol. 5, Issue 1) Peer-ReviewedBackground MicroRNA is a naturally occurring class of non-coding RNA molecules that mediate posttranscriptional gene regulation and are strongly implicated in cellular processes such as cell proliferation,...
- 17From: BMC Medical Genomics. (Vol. 5, Issue 1) Peer-ReviewedBackground Transcriptomic studies in clinical research are essential tools for deciphering the functional elements of the genome and unraveling underlying disease mechanisms. Various technologies have been developed...
- 18From: BMC Medical Genomics. (Vol. 5, Issue 1) Peer-ReviewedBackground Sulfamethoxazole (SMX) is a commonly used antibiotic for prevention of infectious diseases associated with HIV/AIDS and immune-compromised states. SMX-induced hypersensitivity is an idiosyncratic cutaneous...
- 19From: BMC Medical Genomics. (Vol. 5, Issue 1) Peer-ReviewedBackground Glioblastoma (GBM) is the most common and lethal primary brain tumor in adults. Several recent transcriptomic studies in GBM have identified different signatures involving immune genes associated with GBM...
- 20From: BMC Medical Genomics. (Vol. 5, Issue 1) Peer-ReviewedBackground The SH2B1 gene (Src-homology 2B adaptor protein 1 gene) is a solid candidate gene for obesity. Large scale GWAS studies depicted markers in the vicinity of the gene; animal models suggest a potential...