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- 1From: Nature Genetics. (Vol. 45, Issue 4) Peer-ReviewedZsofia Kote-Jarai and colleagues report fine mapping of associations to prostate cancer susceptibility at the TERT locus using high-resolution genotyping and imputation (Hum. Mol. Genet. doi:10.1093/hmg/ddt086, 27 March...
- 2From: Nature Genetics. (Vol. 45, Issue 4) Peer-ReviewedReduction in seed shattering was an important phenotypic change during cereal domestication (1,2). Here we show that a simple morphological change in rice panicle shape, controlled by the SPR3 locus, has a large impact...
- 3From: Nature Genetics. (Vol. 45, Issue 4) Peer-ReviewedThe large-scale Collaborative Oncological Gene-environment Study (COGS) presents new findings that further characterize the genetic bases of breast, ovarian and prostate cancers. We summarize and provide insights into...
- 4From: Nature Genetics. (Vol. 45, Issue 4) Peer-ReviewedEstrogen receptor (ER)-negative tumors represent 20-30% of all breast cancers, with a higher proportion occurring in younger women and women of African ancestry (1). The etiology (2) and clinical behavior (3) of...
- 5From: Nature Genetics. (Vol. 45, Issue 4) Peer-ReviewedInterindividual variation in mean leukocyte telomere length (LTL) is associated with cancer and several age-associated diseases. We report here a genome-wide meta-analysis of 37,684 individuals with replication of...
- 6From: Nature Genetics. (Vol. 45, Issue 4) Peer-ReviewedWe report the results of an association study of melanoma that is based on the genome-wide imputation of the genotypes of 1,353 cases and 3,566 controls of European origin conducted by the GenoMEL consortium. This...
- 7From: Nature Genetics. (Vol. 45, Issue 4) Peer-ReviewedAn ever-larger proportion of the liability to common and complex disease can be obtained by progressively larger studies. However, for most diseases, the sample sizes required to gain usable predictions will be out of...
- 8From: Nature Genetics. (Vol. 45, Issue 4) Peer-ReviewedThe use of the circulatory system to deliver extracellular signals to distant targets is well known, especially for signals secreted in large quantities, such as hormones. In the Journal of Experimental Medicine, Kunder...
- 9From: Nature Genetics. (Vol. 45, Issue 4) Peer-ReviewedLampreys are representatives of an ancient vertebrate lineage that diverged from our own ~500 million years ago. By virtue of this deeply shared ancestry, the sea lamprey (P marinus) genome is uniquely poised to provide...
- 10From: Nature Genetics. (Vol. 45, Issue 4) Peer-ReviewedTo extend findings of breast cancer association studies that have primarily been conducted in European-ancestry populations, Wei Zheng and colleagues systematically examined the association of known breast cancer...
- 11From: Nature Genetics. (Vol. 45, Issue 4) Peer-ReviewedTens of millions of base pairs of euchromatic human genome sequence, including many protein-coding genes, have no known location in the human genome. We describe an approach for localizing the human genome's missing...
- 12From: Nature Genetics. (Vol. 45, Issue 4) Peer-ReviewedTo put this collection of 13 coordinated research papers from the COGS (Collaborative Oncological Gene-environment Study) Consortium into context, we have commissioned two accompanying Commentaries. On page 345, John...
- 13From: Nature Genetics. (Vol. 45, Issue 4) Peer-ReviewedChronic or unresolved inflammation can lead to tissue damage or, during sepsis, to death. In Nature, Serhan and colleagues characterize a potent anti-inflammatory molecule, resolvin D2, which is naturally produced by...
- 14From: Nature Genetics. (Vol. 45, Issue 4) Peer-ReviewedIL-10 exerts its anti-inflammatory effect through direct transcriptional control of cytokine expression as well as indirect modulation of the costimulatory properties of antigen-presenting cells. In the Proceedings of...
- 15From: Nature Genetics. (Vol. 45, Issue 4) Peer-ReviewedGenome-wide association studies (GWAS) have identified four susceptibility loci for epithelial ovarian cancer (EOC), with another two suggestive loci reaching near genome-wide significance. We pooled data from a GWAS...
- 16From: Nature Genetics. (Vol. 45, Issue 4) Peer-ReviewedAge-related macular degeneration (AMD) is a common cause of blindness in older individuals. To accelerate the understanding of AMD biology and help design new therapies, we executed a collaborative genome-wide...
- 17From: Nature Genetics. (Vol. 45, Issue 4) Peer-ReviewedThe importance of commensal microbes for human health is increasingly recognized (1-5), yet the impacts of evolutionary changes in human diet and culture on commensal microbiota remain almost unknown. Two of the...
- 18From: Nature Genetics. (Vol. 45, Issue 4) Peer-ReviewedThe PHG Foundation led a multidisciplinary program, which used results from COGS research identifying genetic variants associated with breast, ovarian and prostate cancers to model risk-stratified prevention for breast...
- 19From: Nature Genetics. (Vol. 45, Issue 4) Peer-Reviewed
Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array
Prostate cancer is the most frequently diagnosed cancer in males in developed countries. To identify common prostate cancer susceptibility alleles, we genotyped 211,155 SNPs on a custom Illumina array (iCOGS) in blood... - 20From: Nature Genetics. (Vol. 45, Issue 4) Peer-ReviewedA previous study from the Consortium of Investigators of Modifiers of BRCA1/2 (CIMBA) reported a genome-wide association study (GWAS) for breast cancer risk in BRCA2 mutation carriers (PLoS Genet. 6, e1001183, 2010),...