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- 1From: Nature Genetics. (Vol. 45, Issue 12) Peer-ReviewedWe report the sequencing at 131x coverage, de novo assembly and analyses of the genome of a female Tibetan wild boar. We also resequenced the whole genomes of 30 Tibetan wild boars from six major distributed locations...
- 2From: Nature Genetics. (Vol. 45, Issue 12) Peer-ReviewedBladder cancer is one of the most common cancers worldwide, with transitional cell carcinoma (TCC) being the predominant form. Here we report a genomic analysis of TCC by both whole-genome and whole-exome sequencing of...
- 3From: Nature Genetics. (Vol. 45, Issue 12) Peer-ReviewedVitamin C, a micronutrient known for its anti-scurvy activity in humans, promotes the generation of induced pluripotent stem cells (iPSCs) (1) through the activity of histone demethylating dioxygenases (2,3) TET...
- 4From: Nature Genetics. (Vol. 45, Issue 12) Peer-ReviewedUrothelial bladder cancer (UBC) is heterogeneous at the clinical, pathological and genetic levels. Tumor invasiveness (T) and grade (G) are the main factors associated with outcome and determine patient management (1)....
- 5From: Nature Genetics. (Vol. 45, Issue 12) Peer-ReviewedSeventy percent of breast cancers express estrogen receptor (ER), and most of these are sensitive to ER inhibition. However, many such tumors for unknown reasons become refractory to inhibition of estrogen action in the...
- 6From: Nature Genetics. (Vol. 45, Issue 12) Peer-ReviewedRecent genomic profiling of childhood acute lymphoblastic leukemia (ALL) identified a high-risk subtype with an expression signature resembling that of Philadelphia chromosome-positive ALL and poor prognosis (Ph-like...
- 7From: Nature Genetics. (Vol. 45, Issue 12) Peer-ReviewedThe simple addition of vitamin C to cell culture medium can induce extensive remodeling of the cellular epigenome and facilitates reprogramming of somatic cells to pluripotency. A new study shows that the activity of...
- 8From: Nature Genetics. (Vol. 45, Issue 12) Peer-ReviewedEsophageal adenocarcinoma is a cancer with rising incidence and poor survival. Most such cancers arise in a specialized intestinal metaplastic epithelium, which is diagnostic of Barrett's esophagus. In a genome-wide...
- 9From: Nature Genetics. (Vol. 45, Issue 12) Peer-ReviewedThe impact of different carcinogenic exposures on the specific patterns of somatic mutation in human tumors remains unclear. To address this issue, we profiled 209 cholangiocarcinomas (CCAs) from Asia and Europe,...
- 10From: Nature Genetics. (Vol. 45, Issue 12) Peer-ReviewedEarlier this year, Richard Young and colleagues reported identification of clusters of enhancers, called super-enhancers, which are bound by the Oct4, Sox2 and Nanog transcription factors and the Mediator complex in...
- 11From: Nature Genetics. (Vol. 45, Issue 12) Peer-ReviewedThe assertions in a scientific article that invite testing can be specifically tagged for peer reviewers to evaluate relative to the experimental evidence offered. Isolated observations as well as theories that are not...
- 12From: Nature Genetics. (Vol. 45, Issue 12) Peer-ReviewedThrough exomic sequencing of 32 intrahepatic cholangiocarcinomas, we discovered frequent inactivating mutations in multiple chromatin-remodeling genes (including BAP1, ARID1A and PBRM1), and mutation in one of these...
- 13From: Nature Genetics. (Vol. 45, Issue 12) Peer-ReviewedSteve Elledge and colleagues have developed a bioinformatic method called TUSON Explorer to identify candidate tumor suppressor genes (TSGs) and oncogenes (OGs) based on sequence mutation parameters (Cell...
- 14From: Nature Genetics. (Vol. 45, Issue 12) Peer-ReviewedComprehensive sequencing of benign and malignant tumors has recently uncovered new driver mutations in childhood tumors. A new report now describes frequent histone H3.3 alterations in chondroblastoma and giant cell...
- 15From: Nature Genetics. (Vol. 45, Issue 12) Peer-ReviewedEleven susceptibility loci for late-onset Alzheimer's disease (LOAD) were identified by previous studies; however, a large portion of the genetic risk for this disease remains unexplained. We conducted a large,...
- 16From: Nature Genetics. (Vol. 45, Issue 12) Peer-ReviewedHere we report the discovery of truncating mutations of the gene encoding the cohesin subunit STAG2, which regulates sister chromatid cohesion and segregation, in 36% of papillary non-invasive urothelial carcinomas and...
- 17From: Nature Genetics. (Vol. 45, Issue 12) Peer-ReviewedBreast cancer is the most prevalent cancer in women, and over two-thirds of cases express estrogen receptor-a (ER-a, encoded by ESR1). Through a prospective clinical sequencing program for advanced cancers, we enrolled...
- 18From: Nature Genetics. (Vol. 45, Issue 12) Peer-ReviewedTwo new studies report the identification of activating ESR1 gene mutations in aromatase inhibitor-resistant metastatic breast cancers. This insight into therapeutic resistance suggests new approaches that may be useful...
- 19From: Nature Genetics. (Vol. 45, Issue 12) Peer-ReviewedMost fruits in our daily diet are the products of domestication and breeding. Here we report a map of genome variation for a major fruit that encompasses ~3.6 million variants, generated by deep resequencing of 115...
- 20From: Nature Genetics. (Vol. 45, Issue 12) Peer-ReviewedThe diagnosed incidence of small intestine neuroendocrine tumors (SI-NETs) is increasing, and the underlying genomic mechanisms have not yet been defined. Using exome- and genome-sequence analysis of SI-NETs, we...