Showing Results for
- Academic Journals (37)
Search Results
- 37
Academic Journals
- 37
- Search Terms:
- 1From: Nature Genetics. (Vol. 44, Issue 3) Peer-ReviewedGenome-wide association studies have revealed that common noncoding variants in MTNR1B (encoding melatonin receptor 1 B, also known as [MT.sub.2]) increase type 2 diabetes (T2D) risk (1,2) Although the strongest...
- 2From: Nature Genetics. (Vol. 44, Issue 3) Peer-ReviewedMultiple genetic loci associated with obesity or body mass index (BMI) have been identified through genome-wide association studies conducted predominantly in populations of European ancestry. We performed a...
- 3From: Nature Genetics. (Vol. 44, Issue 3) Peer-ReviewedSchizophrenia is a complex disorder caused by both genetic and environmental factors. Using 9,087 affected individuals, 12,171 controls and 915,354 imputed SNPs from the Schizophrenia Psychiatric Genome-Wide Association...
- 4From: Nature Genetics. (Vol. 44, Issue 3) Peer-ReviewedMacrophages engulf apoptotic cells to prevent immune responses to self antigens. In Nature Medicine, Chawla and colleagues show that PPAR-[delta], a sensor of fatty acids, is essential for efficient macrophage...
- 5From: Nature Genetics. (Vol. 44, Issue 3) Peer-ReviewedThe 29th of February is not just a leap-year day; it is also Rare Disease Day (http://www.rarediseaseday.org/). It is estimated that 80% of rare diseases are of genetic origin. Organizations such as the Genetic Alliance...
- 6From: Nature Genetics. (Vol. 44, Issue 3) Peer-Reviewed
Germline mutations in DIS3L2 cause the Perlman syndrome of overgrowth and Wilms tumor susceptibility
Perlman syndrome is a congenital overgrowth syndrome inherited in an autosomal recessive manner that is associated with Wilms tumor susceptibility. We mapped a previously unknown susceptibility locus to 2q37.1 and... - 7From: Nature Genetics. (Vol. 44, Issue 3) Peer-ReviewedInfantile hypertrophic pyloric stenosis (IHPS) is a severe condition characterized by hypertrophy of the pyloric sphincter muscle. We conducted a genome-wide association study (GWAS) on 1,001 surgery-confirmed cases and...
- 8From: Nature Genetics. (Vol. 44, Issue 3) Peer-ReviewedEwing sarcoma, a pediatric tumor characterized by EWSR1-ETS fusions, is predominantly observed in populations of European ancestry. We performed a genome-wide association study (GWAS) of 401 French individuals with...
- 9From: Nature Genetics. (Vol. 44, Issue 3) Peer-ReviewedThe nematode Caenorhabditis elegans is central to research in molecular, cell and developmental biology, but nearly all of this research has been conducted on a single strain of C. elegans. Little is known about the...
- 10From: Nature Genetics. (Vol. 44, Issue 3) Peer-ReviewedThe genetic association of the major histocompatibility complex (MHC) to rheumatoid arthritis risk has commonly been attributed to alleles in HLA-DRB1. However, debate persists about the identity of the causal variants...
- 11From: Nature Genetics. (Vol. 44, Issue 3) Peer-ReviewedA new study refines the association signals for rheumatoid arthritis susceptibility in the major histocompatibility complex (MHC) region to five amino-acid positions encoded in three HLA genes, all within...
- 12From: Nature Genetics. (Vol. 44, Issue 3) Peer-ReviewedCTL-mediated target cell killing requires polarization of the microtubule-organizing center (MTOC) and cytotoxic granules toward the target cell interface. In Immunity, groups led by Griffiths and Sykulev shed light on...
- 13From: Nature Genetics. (Vol. 44, Issue 3) Peer-ReviewedAfter imputation of data from the 1000 Genomes Project into a genome-wide dataset of Ghanaian individuals with tuberculosis and controls, we identified a resistance locus on chromosome 11p13 downstream of the WT1 gene...
- 14From: Nature Genetics. (Vol. 44, Issue 3) Peer-ReviewedALK rearrangements occur in 4% of non small cell lung cancer patients, which is approximately 8,000 cases in the US and 40,000 cases worldwide each year. Although most ALK-positive individuals initially respond to ALK...
- 15From: Nature Genetics. (Vol. 44, Issue 3) Peer-ReviewedIL-10 exerts its anti-inflammatory effect through direct transcriptional control of cytokine expression as well as indirect modulation of the costimulatory properties of antigen-presenting cells. In the Proceedings of...
- 16From: Nature Genetics. (Vol. 44, Issue 3) Peer-ReviewedNuclear magnetic resonance assays allow for measurement of a wide range of metabolic phenotypes. We report here the results of a GWAS on 8,330 Finnish individuals genotyped and imputed at 7.7 million SNPs for a range of...
- 17From: Nature Genetics. (Vol. 44, Issue 3) Peer-ReviewedChronic or unresolved inflammation can lead to tissue damage or, during sepsis, to death. In Nature, Serhan and colleagues characterize a potent anti-inflammatory molecule, resolvin D2, which is naturally produced by...
- 18From: Nature Genetics. (Vol. 44, Issue 3) Peer-ReviewedTo identify somatic mutations in pediatric diffuse intrinsic pontine glioma (DIPG), we performed whole-genome sequencing of DNA from seven DIPGs and matched germline tissue and targeted sequencing of an additional 43...
- 19From: Nature Genetics. (Vol. 44, Issue 3) Peer-ReviewedWith the increasing availability oflarge-scale sequencing data sets, there has been a growing need for new statistical methods for rare variant association analyses. Several new methods have been described that employ...
- 20From: Nature Genetics. (Vol. 44, Issue 3) Peer-ReviewedBreast cancer is the most common cancer among women. To date, 22 common breast cancer susceptibility loci have been identified accounting for ~8% of the heritability of the disease. We attempted to replicate 72...