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- 1From: Nature Genetics. (Vol. 43, Issue 9) Peer-ReviewedJason Locasale, Lewis Cantley, Matthew Vander Heiden and colleagues show that PHGDH is amplified in some human cancers and diverts a relatively large amount of glycolytic carbon into serine and glycine biosynthesis. They...
- 2From: Nature Genetics. (Vol. 43, Issue 9) Peer-ReviewedSchizophrenia is a severe psychiatric disorder that profoundly affects cognitive, behavioral and emotional processes. The wide spectrum of symptoms and clinical variability in schizophrenia suggest a complex genetic...
- 3From: Nature Genetics. (Vol. 43, Issue 9) Peer-ReviewedCarl A Anderson, Gabrielle Boucher, Charlie W Lees, Andre Franke, Mauro D'Amato, Kent D Taylor, James C Lee, Philippe Goyette, Marcin Imielinski, Anna Latiano, Caroline Lagace, Regan Scott, Leila Amininejad, Suzannah...
- 4From: Nature Genetics. (Vol. 43, Issue 9) Peer-ReviewedMacrophages engulf apoptotic cells to prevent immune responses to self antigens. In Nature Medicine, Chawla and colleagues show that PPAR-[delta], a sensor of fatty acids, is essential for efficient macrophage...
- 5From: Nature Genetics. (Vol. 43, Issue 9) Peer-ReviewedTransitional cell carcinoma (TCC) is the most common type of bladder cancer. Here we sequenced the exomes of nine individuals with TCC and screened all the somatically mutated genes in a prevalence set of 88 additional...
- 6From: Nature Genetics. (Vol. 43, Issue 9) Peer-ReviewedFragile X syndrome is the most commonly inherited form of intellectual disability and is caused by mutations affecting fragile X mental retardation protein (FMRP, encoded by FMR1). FMRP binds RNA and is thought to...
- 7From: Nature Genetics. (Vol. 43, Issue 9) Peer-ReviewedDerivation of patient-specific induced pluripotent stem cells (iPSCs), and zinc-finger nuclease (ZFN)-mediated genome editing of human embryonic stem cells (ESCs) and iPSCs, have both been previously described. Now,...
- 8From: Nature Genetics. (Vol. 43, Issue 9) Peer-ReviewedA variant of the PTPN22-encoded Lyp phosphatase (Lyp620W) confers risk for autoimmune disease, but the mechanisms underlying this association remain unclear. We show here that mice expressing the Lyp variant homolog...
- 9From: Nature Genetics. (Vol. 43, Issue 9) Peer-ReviewedViral dissemination requires the release of newly synthesized virions from hijacked cells. In Cell, Bieniasz and colleagues report how tetherin, an interferon-inducible protein, blocks the release of HIV and other...
- 10From: Nature Genetics. (Vol. 43, Issue 9) Peer-ReviewedTo understand the genetic heterogeneity underlying developmental delay, we compared copy number variants (CNVs) in 15,767 children with intellectual disability and various congenital defects (cases) to CNVs in 8,329...
- 11From: Nature Genetics. (Vol. 43, Issue 9) Peer-ReviewedAsthma is a common disease with a complex risk architecture including both genetic and environmental factors. We performed a meta-analysis of North American genome-wide association studies of asthma in 5,416 individuals...
- 12From: Nature Genetics. (Vol. 43, Issue 9) Peer-ReviewedThe Australo-Anglo-American Spondyloarthritis Consortium (TASC) & the Wellcome Trust Case Control Consortium 2 (WTCCC2) Nat. Genet. 43, 761-767 (2011); published online 10 July 2011; corrected after print 11 August 2011...
- 13From: Nature Genetics. (Vol. 43, Issue 9) Peer-ReviewedTo identify susceptibility loci for meningioma, we conducted a genome-wide association study of 859 affected individuals (cases) and 704 controls with validation in two independent sample sets totaling 774 cases and...
- 14From: Nature Genetics. (Vol. 43, Issue 9) Peer-ReviewedMicroRNAs (miRNAs) are short, highly conserved noncoding RNA molecules that repress gene expression in a sequence- dependent manner. We performed single-cell measurements using quantitative fluorescence microscopy and...
- 15From: Nature Genetics. (Vol. 43, Issue 9) Peer-ReviewedStudies of recombination and how it varies depend crucially on accurate recombination maps. We propose a new approach for constructing high-resolution maps of relative recombination rates based on the observation of...
- 16From: Nature Genetics. (Vol. 43, Issue 9) Peer-ReviewedCTL-mediated target cell killing requires polarization of the microtubule-organizing center (MTOC) and cytotoxic granules toward the target cell interface. In Immunity, groups led by Griffiths and Sykulev shed light on...
- 17From: Nature Genetics. (Vol. 43, Issue 9) Peer-ReviewedAdvances in both pedigree-based and population-based genetic maps in recent years have helped unravel some of the mysteries of human meiotic recombination. The publication of the first admixture-derived human genetic...
- 18From: Nature Genetics. (Vol. 43, Issue 9) Peer-ReviewedDiffuse large B-cell lymphoma (DLBCL) is the most common form of human lymphoma. Although a number of structural alterations have been associated with the pathogenesis of this malignancy, the full spectrum of genetic...
- 19From: Nature Genetics. (Vol. 43, Issue 9) Peer-ReviewedThe conversion of mouse skin fibroblasts directly to neurons was recently demonstrated, and now Asa Abeliovich and colleagues report the conversion of human skin fibroblasts from individuals with Alzheimer's disease...
- 20From: Nature Genetics. (Vol. 43, Issue 9) Peer-ReviewedThrough exomic sequencing of ten hepatitis C virus (HCV)associated hepatocellular carcinomas (HCC) and subsequent evaluation of additional affected individuals, we discovered novel inactivating mutations of ARID2 in...