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- 1From: Nature Genetics. (Vol. 43, Issue 10) Peer-ReviewedKerrin S Small, Asa K Hedman, Elin Grundberg, Alexandra C Nica, Gudmar Thorleifsson, Augustine Kong, Unnur Thorsteindottir, So-Youn Shin, Hannah B Richards, the GIANT Consortium, the MAGIC Investigators, the DIAGRAM...
- 2From: Nature Genetics. (Vol. 43, Issue 10) Peer-ReviewedWe examined the role of common genetic variation in schizophrenia in a genome-wide association study of substantial size: a stage 1 discovery sample of 21,856 individuals of European ancestry and a stage 2 replication...
- 3From: Nature Genetics. (Vol. 43, Issue 10) Peer-ReviewedThe ratio between the second digit (2D) and fourth digit (4D) length differs between human males and females. 2D is generally shorter than 4D in males (2D:4D < 1), whereas 2D is typically the same or longer than 4D in...
- 4From: Nature Genetics. (Vol. 43, Issue 10) Peer-ReviewedInterleukin 7 (IL-7) and its receptor, formed by IL-7R[alpha] (encoded by IL7R) and [gamma]c, are essential for normal T-cell development and homeostasis. Here we show that IL7R is an oncogene mutated in T-cell acute...
- 5From: Nature Genetics. (Vol. 43, Issue 10) Peer-ReviewedTwo new studies take distinct population genetic approaches to analyzing whole-genome sequencing data sets in order to estimate human demographic parameters. These papers refine our understanding of the relationships...
- 6From: Nature Genetics. (Vol. 43, Issue 10) Peer-ReviewedCarotid intima media thickness (cIMT) and plaque determined by ultrasonography are established measures of subclinical atherosclerosis that each predicts future cardiovascular disease events. We conducted a...
- 7From: Nature Genetics. (Vol. 43, Issue 10) Peer-ReviewedWe conducted a combined genome-wide association study (GWAS) of 7,481 individuals with bipolar disorder (cases) and 9,250 controls as part of the Psychiatric GWAS Consortium. Our replication study tested 34 SNPs in...
- 8From: Nature Genetics. (Vol. 43, Issue 10) Peer-ReviewedThorsten Thye, Fredrik O Vannberg, Sunny H Wong, Ellis Owusu-Dabo, Ivy Osei, John Gyapong, Giorgio Sirugo, Fatou Sisay- Joof, Anthony Enimil, Margaret A Chinbuah, Sian Floyd, David K Warndorff, Lifted Sichali, Simon...
- 9From: Nature Genetics. (Vol. 43, Issue 10) Peer-ReviewedBecause only a small fraction of asbestos-exposed individuals develop malignant mesothelioma (1), and because mesothelioma clustering is observed in some families, we searched for genetic predisposing factors. We...
- 10From: Nature Genetics. (Vol. 43, Issue 10) Peer-ReviewedTwo new studies describe germline mutations in BAP1 in putatively dissimilar cancer-related syndromes. The spectrum of neoplasms associated with these germline mutations suggest that BAP1 has an important tumor...
- 11From: Nature Genetics. (Vol. 43, Issue 10) Peer-ReviewedWe carried out a genome-wide association study of type-2 diabetes (T2D) in individuals of South Asian ancestry. Our discovery set included 5,561 individuals with T2D (cases) and 14,458 controls drawn from studies in...
- 12From: Nature Genetics. (Vol. 43, Issue 10) Peer-ReviewedUterine leiomyomas, or fibroids, are benign tumors arising from the smooth-muscle layer of the uterus that can produce a range of clinical symptoms. A new study by Lauri Aaltonen and colleagues (Science, published...
- 13From: Nature Genetics. (Vol. 43, Issue 10) Peer-ReviewedWe report an allelic series of eight mutations in GATA2 underlying Emberger syndrome, an autosomal dominant primary lymphedema associated with a predisposition to acute myeloid leukemia. GATA2 is a transcription factor...
- 14From: Nature Genetics. (Vol. 43, Issue 10) Peer-ReviewedWhole-genome sequences provide a rich source of information about human evolution. Here we describe an effort to estimate key evolutionary parameters based on the whole-genome sequences of six individuals from diverse...
- 15From: Nature Genetics. (Vol. 43, Issue 10) Peer-ReviewedCommon acquired melanocytic nevi are benign neoplasms that are composed of small, uniform melanocytes and are typically present as flat or slightly elevated pigmented lesions on the skin. We describe two families with a...
- 16From: Nature Genetics. (Vol. 43, Issue 10) Peer-Reviewedactivation of the serine-threonine kinase AKT is associated with tumor promotion, whereas its downstream FOXO transcription factor targets are associated with tumor-suppressor functions. Now, David scadden and...
- 17From: Nature Genetics. (Vol. 43, Issue 10) Peer-ReviewedMicroRNAs (miRNAs) are key regulators of gene expression in animals and plants. Studies in a variety of model organisms show that miRNAs modulate developmental processes. To our knowledge, the only hereditary condition...
- 18From: Nature Genetics. (Vol. 43, Issue 10) Peer-ReviewedFostering scientific progress and ensuring that the community has access to human exome data can be difficult to do when faced with the divergent interests of patients, data generators, data funders and potential data...
- 19From: Nature Genetics. (Vol. 43, Issue 10) Peer-ReviewedNumerous genetic loci have been associated with systolic blood pressure (SBP) and diastolic blood pressure (DBP) in Europeans (1-3). We now report genome-wide association studies of pulse pressure (PP) and mean arterial...
- 20From: Nature Genetics. (Vol. 43, Issue 10) Peer-ReviewedSterile worker castes in eusocial insects have been attributed to kin selection theory, in which the reproductive success of a relative is favored, even at the expense of one's own survival and reproduction. In honeybee...