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- 1From: Nature Genetics. (Vol. 42, Issue 8) Peer-ReviewedTo identify susceptibility loci for non-Hodgkin lymphoma subtypes, we conducted a three-stage genome-wide association study. We identified two variants associated with follicular lymphoma at 6p21.32 (rs10484561, combined...
- 2From: Nature Genetics. (Vol. 42, Issue 8) Peer-ReviewedWe genotyped individuals with primary biliary cirrhosis and unaffected controls for suggestive risk loci (genome-wide association P < 1 x [10.sup.-4]) identified in a previous genome-wide association study. Combined...
- 3From: Nature Genetics. (Vol. 42, Issue 8) Peer-ReviewedChronic or unresolved inflammation can lead to tissue damage or, during sepsis, to death. In Nature, Serhan and colleagues characterize a potent anti-inflammatory molecule, resolvin D2, which is naturally produced by...
- 4From: Nature Genetics. (Vol. 42, Issue 8) Peer-ReviewedA genome-wide association screen for primary biliary cirrhosis risk alleles was performed in an Italian cohort. The results from the Italian cohort replicated IL12A and IL12RB associations, and a combined meta-analysis...
- 5From: Nature Genetics. (Vol. 42, Issue 8) Peer-ReviewedmicroRNAs (miRNAs) are often globally reduced in human cancers, but the clinical relevance of miRNAs in cancer is unclear. Now, Stefano Piccolo and colleagues report a role for miRNAs in regulation of metastasis (Cell...
- 6From: Nature Genetics. (Vol. 42, Issue 8) Peer-ReviewedDNA double-strand breaks (DSBs) can lead to the development of genomic rearrangements, which are hallmarks of cancer. Fusions between TMPRSS2, encoding the transmembrane serine protease isoform 2, and ERG, encoding the...
- 7From: Nature Genetics. (Vol. 42, Issue 8) Peer-ReviewedPeople have lived in the Mediterranean region long enough to disagree about almost everything. The region has a long demographic history overlaid with considerable diversity of ethnicity, language and belief....
- 8From: Nature Genetics. (Vol. 42, Issue 8) Peer-ReviewedSoft-tissue sarcomas, which result in approximately 10,700 diagnoses and 3,800 deaths per year in the United States (1), show remarkable histologic diversity, with more than 50 recognized subtypes (2). However,...
- 9From: Nature Genetics. (Vol. 42, Issue 8) Peer-ReviewedTerri H Beaty, Jeffrey C Murray, Mary L Marazita, Ronald G Munger, Ingo Ruczinski Jacqueline B Hetmanski, Kung Yee Liang, Tao Wu, Tanda Murray, M Daniele Fallin, Richard A Redett, Gerald Raymond, Holger Schwender, Shin...
- 10From: Nature Genetics. (Vol. 42, Issue 8) Peer-ReviewedDeficiency in the serine protease inhibitor LEKTI is the etiological origin of Netherton syndrome, which causes detachment of the stratum corneum and chronic inflammation. Here we show that the membrane protease...
- 11From: Nature Genetics. (Vol. 42, Issue 8) Peer-ReviewedThe signals that regulate the growth of new neurons in the mature adult brain are not well known. Now, Fred Gage and colleagues report that neural stem cells (Nscs) in the adult hippocampus are regulated by BMP...
- 12From: Nature Genetics. (Vol. 42, Issue 8) Peer-ReviewedMacrophages engulf apoptotic cells to prevent immune responses to self antigens. In Nature Medicine, Chawla and colleagues show that PPAR-[delta], a sensor of fatty acids, is essential for efficient macrophage...
- 13From: Nature Genetics. (Vol. 42, Issue 8) Peer-ReviewedBehcet's disease is a chronic systemic inflammatory disorder characterized by four major manifestations: recurrent ocular symptoms, oral and genital ulcers and skin lesions (1). We conducted a genome-wide association...
- 14From: Nature Genetics. (Vol. 42, Issue 8) Peer-ReviewedA new study finds that individuals with high plasma triglyceride levels carry approximately twice as many rare, coding genetic variants within four candidate genes identified through genome-wide association studies than...
- 15From: Nature Genetics. (Vol. 42, Issue 8) Peer-ReviewedWe performed a genome-wide association study on 1,292 individuals with abdominal aortic aneurysms (AAAs) and 30,503 controls from Iceland and The Netherlands, with a follow-up of top markers in up to 3,267 individuals...
- 16From: Nature Genetics. (Vol. 42, Issue 8) Peer-ReviewedLong intergenic noncoding RNAs (lincRNAs) have recently emerged as an important class of regulatory RNAs that recruit histone modification complexes such as PRC2 to target sites in chromatin to influence gene...
- 17From: Nature Genetics. (Vol. 42, Issue 8) Peer-ReviewedAlthough the pathogenesis of endometriosis is not well understood, genetic factors have been considered to have critical roles in its etiology. Through a genome-wide association study and a replication study using a...
- 18From: Nature Genetics. (Vol. 42, Issue 8) Peer-ReviewedThe US government has proposed the development of scientific centers of excellence to solve global challenges. We propose such a center of excellence devoted to the genomic analysis of mediterranean populations of all...
- 19From: Nature Genetics. (Vol. 42, Issue 8) Peer-ReviewedIn myelodysplastic syndromes (MDS), deletions of chromosome 7 or 7q are common and correlate with a poor prognosis. The relevant genes on chromosome 7 are unknown. We report here that EZH2, located at 7q36.1, is...
- 20From: Nature Genetics. (Vol. 42, Issue 8) Peer-ReviewedThe use of the circulatory system to deliver extracellular signals to distant targets is well known, especially for signals secreted in large quantities, such as hormones. In the Journal of Experimental Medicine, Kunder...